Advances in research on pharmacotherapy of sarcopenia.
aging
muscle wasting
pathogenesis
pharmacotherapy
sarcopenia
signaling
Journal
Aging medicine (Milton (N.S.W))
ISSN: 2475-0360
Titre abrégé: Aging Med (Milton)
Pays: Australia
ID NLM: 101741954
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
31
05
2021
revised:
07
07
2021
accepted:
07
07
2021
entrez:
23
9
2021
pubmed:
24
9
2021
medline:
24
9
2021
Statut:
epublish
Résumé
Sarcopenia is a comprehensive degenerative disease with the progressive loss of skeletal muscle mass with age, accompanied by the loss of muscle strength and muscle dysfunction. As a new type of senile syndrome, sarcopenia seriously threatens the health of the elderly. The first-line treatment for sarcopenia is exercise and nutritional supplements. However, pharmacotherapy will provide more reliable and sustainable interventions in geriatric medicine. Clinical trials of new drugs targeting multiple molecules are ongoing. This article focuses on the latest progress in pharmacotherapeutic approaches of sarcopenia in recent years by comprehensively reviewing the clinical outcomes of the existing and emerging pharmacotherapies as well as the molecular mechanisms underlying their therapeutic benefits and side effects.
Identifiants
pubmed: 34553120
doi: 10.1002/agm2.12168
pii: AGM212168
pmc: PMC8444957
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
221-233Informations de copyright
© 2021 The Authors. Aging Medicine published by Beijing Hospital and John Wiley & Sons Australia, Ltd.
Déclaration de conflit d'intérêts
Nothing to declare.
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