Case report: two cases of mature oocytes found in prepubertal girls during ovarian tissue cryopreservation.
IVM
OTC
fertility preservation
oocyte
prepubertal ovary
Journal
F&S reports
ISSN: 2666-3341
Titre abrégé: F S Rep
Pays: United States
ID NLM: 101766618
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
24
11
2020
revised:
23
03
2021
accepted:
30
03
2021
entrez:
23
9
2021
pubmed:
24
9
2021
medline:
24
9
2021
Statut:
epublish
Résumé
To report two cases of mature oocytes found in prepubertal girls undergoing ovarian tissue cryopreservation (OTC). Case report. Large tertiary care children's hospital and a private fertility clinic. An 8-year-old prepubertal girl with β-thalassemia and a 2-year-old girl with sickle cell disease who both underwent OTC before bone marrow transplantations. Laparoscopic right oophorectomy was performed in each patient. The ovarian cortical tissue was processed for slow freezing and long-term storage, and all oocytes were subsequently vitrified. Oocytes found at the time of OTC processing for fertility preservation. After a complete right oophorectomy, one mature metaphase II oocyte was discovered on tissue processing for OTC in each patient. Neither patient has yet returned for use of tissue or oocytes. To our knowledge, this is the first report of mature oocytes found during prepubertal OTC processing. These findings may indicate the need for increased research regarding prepubertal oocyte development and suggest that the technique of examining the media for both mature and immature oocytes at the time of OTC should become more widespread and perhaps recommended in prepubertal patients to optimize fertility preservation methods.
Identifiants
pubmed: 34553154
doi: 10.1016/j.xfre.2021.03.007
pii: S2666-3341(21)00033-7
pmc: PMC8441562
doi:
Types de publication
Journal Article
Langues
eng
Pagination
296-299Informations de copyright
© 2021 Published by Elsevier Inc. on behalf of American Society for Reproductive Medicine.
Références
Fertil Steril. 2019 Aug;112(2):315-322
pubmed: 31056316
Reprod Biomed Online. 2017 Jun;34(6):575-582
pubmed: 28365199
Hum Reprod. 2020 Sep 1;35(9):2026-2036
pubmed: 32829388
Minerva Ginecol. 2018 Aug;70(4):432-435
pubmed: 29696941
Fertil Steril. 2016 Jan;105(1):6-12
pubmed: 26674557
Clin Endocrinol Metab. 1978 Nov;7(3):469-85
pubmed: 153213
Hum Reprod. 2016 Apr;31(4):750-62
pubmed: 26848188
J Assist Reprod Genet. 2012 Jun;29(6):507-12
pubmed: 22476503
Hum Reprod. 1994 Apr;9(4):597-603
pubmed: 8046009
J Adolesc Young Adult Oncol. 2020 Dec;9(6):662-666
pubmed: 32456570
J Assist Reprod Genet. 2020 Jun;37(6):1323-1326
pubmed: 32390071
J Vis Exp. 2020 Oct 23;(164):
pubmed: 33165323
Fertil Steril. 2009 Aug;92(2):458-63
pubmed: 18952208
Fertil Steril. 2019 Dec;112(6):1022-1033
pubmed: 31843073
Arch Gynecol Obstet. 2018 Jan;297(1):257-267
pubmed: 29181578
Arch Gynecol Obstet. 2011 Sep;284(3):643-6
pubmed: 20922399
Fertil Steril. 2019 Nov;112(5):908-921
pubmed: 31594631
Crit Rev Oncol Hematol. 2016 Jul;103:10-21
pubmed: 27184425
Hum Reprod. 2015 Sep;30(9):2107-9
pubmed: 26062556
Lancet Oncol. 2014 Sep;15(10):1129-36
pubmed: 25130994
Reprod Biomed Online. 2020 Nov;41(5):869-873
pubmed: 32843309
Fertil Steril. 2020 Aug;114(2):374-378
pubmed: 32386868