Regulation of innate immune signaling pathways by autophagy in dengue virus infection.
antiviral immunity
autophagy
dengue virus
innate immune response
viral replication
Journal
IUBMB life
ISSN: 1521-6551
Titre abrégé: IUBMB Life
Pays: England
ID NLM: 100888706
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
revised:
24
08
2021
received:
12
07
2021
accepted:
07
09
2021
pubmed:
24
9
2021
medline:
17
3
2022
entrez:
23
9
2021
Statut:
ppublish
Résumé
Autophagy is not only an intracellular recycling degradation system that maintains cellular homeostasis but is also a component of innate immunity that contributes to host defense against viral infection. The viral components as well as viral particles trapped in autophagosomes can be delivered to lysosomes for degradation. Abundant evidence indicates that dengue virus (DENV) has evolved the potent ability to hijack or subvert autophagy process for escaping host immunity and promoting viral replication. Moreover, autophagy is often required to deliver viral components to pattern recognition receptors signaling for interferon (IFN)-mediated viral elimination. Hence, this review summarizes DENV-induced autophagy, which exhibits dual effects on proviral activity of promoting replication and antiviral activity to eliminating viral particles.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
170-179Informations de copyright
© 2021 International Union of Biochemistry and Molecular Biology.
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