Rational Design, Synthesis and Evaluation of Oxazolo[4,5-c]-quinolinone Analogs as Novel Interleukin-33 Inhibitors.
Allergy
Cytokine
Inhibitors
Interleukin-33
Oxazoloquinoline
Journal
Chemistry, an Asian journal
ISSN: 1861-471X
Titre abrégé: Chem Asian J
Pays: Germany
ID NLM: 101294643
Informations de publication
Date de publication:
15 Nov 2021
15 Nov 2021
Historique:
revised:
14
09
2021
received:
04
08
2021
pubmed:
24
9
2021
medline:
16
12
2021
entrez:
23
9
2021
Statut:
ppublish
Résumé
Interleukin-33 (IL-33) is an epithelial-derived cytokine that plays an important role in immune-mediated diseases such as asthma, atopic dermatitis, and rheumatoid arthritis. Although IL-33 is considered a potential target for the treatment of allergy-related diseases, no small molecule that inhibits IL-33 has been reported. Based on the structure-activity relationship and in vitro 2D NMR studies employing
Identifiants
pubmed: 34553505
doi: 10.1002/asia.202100896
doi:
Substances chimiques
IL33 protein, human
0
IL6 protein, human
0
Interleukin-1 Receptor-Like 1 Protein
0
Interleukin-33
0
Interleukin-6
0
Quinolones
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3702-3712Subventions
Organisme : National Research Foundation funded by the Ministry of Science, ICT & Future Planning
Organisme : Ministry of Education of Korea
ID : 2014R1A4A1007304
Organisme : Ministry of Education of Korea
ID : 2019R1A6A1A03031807
Informations de copyright
© 2021 Wiley-VCH GmbH.
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