Practical application of in vivo MRI-based brown adipose tissue measurements in infants.
Journal
Obesity (Silver Spring, Md.)
ISSN: 1930-739X
Titre abrégé: Obesity (Silver Spring)
Pays: United States
ID NLM: 101264860
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
revised:
17
05
2021
received:
27
12
2020
accepted:
19
05
2021
entrez:
23
9
2021
pubmed:
24
9
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
The role of brown adipose tissue (BAT) in infant metabolism remains poorly understood, primarily because of the inherent limitation of positron emission tomography/computed tomography imaging to measure BAT, which is not suitable for infants. The aims of this method development study were to assess the feasibility, intra-rater reliability, interscan repeatability, and physiological relevance of measuring BAT in infants using magnetic resonance imaging (MRI). A total of 10 nonsedated infants (mean age, 22.6 [1.3] days old) completed two 3-T MRI exams using chemical-shift-encoded water-fat scans 6.2 (2.8) days apart. Candidate BAT voxels in the supraclavicular region were identified based on fat signal fraction (FSF). The volumes of BAT depots were manually traced, and FSF was calculated. Whole-body fat mass was determined using dual-energy x-ray absorptiometry. Images were successfully obtained from 19 of 20 (95%) attempted scans. The mean BAT volume was 5.41 (SD 1.1) cm This method development study supports the use of MRI to obtain reliable and quantitative measurements of BAT volume in infants.
Identifiants
pubmed: 34553508
doi: 10.1002/oby.23237
pmc: PMC9115839
mid: NIHMS1802547
doi:
Substances chimiques
Water
059QF0KO0R
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1676-1683Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK124806
Pays : United States
Organisme : Pennington/Louisiana Nutrition Obesity Research Center
ID : P30 DK072476-10
Organisme : NIDDK NIH HHS
ID : P30 DK072476
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM104940
Pays : United States
Organisme : NINR NIH HHS
ID : R01 NR017644
Pays : United States
Informations de copyright
© 2021 The Obesity Society.
Références
J Clin Densitom. 2010 Apr-Jun;13(2):151-60
pubmed: 20378381
Horm Res. 2006;65 Suppl 3:65-9
pubmed: 16612116
Growth. 1976 Dec;40(4):329-41
pubmed: 1010389
J Pediatr. 2011 Dec;159(6):939-44
pubmed: 21839465
J Magn Reson Imaging. 2013 Oct;38(4):885-96
pubmed: 23440739
J Clin Invest. 2012 Feb;122(2):545-52
pubmed: 22269323
Pediatr Res. 2004 Mar;55(3):437-41
pubmed: 14681496
N Engl J Med. 2009 Apr 9;360(15):1509-17
pubmed: 19357406
Int J Obes (Lond). 2016 Nov;40(11):1655-1661
pubmed: 27430878
Methods Enzymol. 2014;537:141-59
pubmed: 24480345
J Endocr Soc. 2019 Oct 14;3(12):2374-2384
pubmed: 31745532
Front Endocrinol (Lausanne). 2020 Aug 07;11:421
pubmed: 32849257
Pediatr Res. 2017 Dec;82(6):1017-1021
pubmed: 28723888
Magn Reson Imaging. 2014 Feb;32(2):107-17
pubmed: 24239336
PLoS One. 2013 Oct 30;8(10):e77907
pubmed: 24205024
Pediatr Obes. 2012 Aug;7(4):304-12
pubmed: 22577092
J Magn Reson Imaging. 2012 Apr;35(4):938-42
pubmed: 22180228
AJR Am J Roentgenol. 2013 Jan;200(1):177-83
pubmed: 23255760
Handb Exp Pharmacol. 2019;251:299-324
pubmed: 30099625
Diabetes. 2009 Nov;58(11):2583-7
pubmed: 19696186
J Nucl Med. 2013 Sep;54(9):1584-7
pubmed: 23868958
N Engl J Med. 2009 Apr 9;360(15):1500-8
pubmed: 19357405
J Anat. 1972 May;112(Pt 1):35-9
pubmed: 5086212
Eur J Clin Nutr. 2015 Dec;69(12):1279-89
pubmed: 26242725
J Osteoporos. 2012;2012:672403
pubmed: 23091773
J Pediatr. 2016 Jun;173:116-21
pubmed: 27039232
Stem Cells Int. 2016;2016:6067349
pubmed: 27073398
J Clin Endocrinol Metab. 2021 Jan 23;106(2):e943-e956
pubmed: 33135728