Multiscale analysis reveals that diet-dependent midgut plasticity emerges from alterations in both stem cell niche coupling and enterocyte size.

D. melanogaster cell size developmental biology diet gut growth intestinal stem cell organ plasticity regenerative medicine shrinkage stem cell-niche coupling stem cells

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
23 09 2021
Historique:
received: 16 12 2020
accepted: 22 09 2021
pubmed: 24 9 2021
medline: 1 12 2021
entrez: 23 9 2021
Statut: epublish

Résumé

The gut is the primary interface between an animal and food, but how it adapts to qualitative dietary variation is poorly defined. We find that the

Identifiants

pubmed: 34553686
doi: 10.7554/eLife.64125
pii: 64125
pmc: PMC8528489
doi:
pii:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Medical Research Council
ID : MR/S033939/1
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI148541
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG065733
Pays : United States

Informations de copyright

© 2021, Bonfini et al.

Déclaration de conflit d'intérêts

AB, AD, DD, JR, XL, PH, NB No competing interests declared

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Auteurs

Alessandro Bonfini (A)

Cornell Institute of Host-Microbe Interactions and Disease, Department of Entomology, Cornell University, Ithaca, United States.

Adam J Dobson (AJ)

Institute of Molecular, Cell and Systems Biology, University of Glasgow, Glasgow, United Kingdom.

David Duneau (D)

Université Toulouse 3 Paul Sabatier, CNRS, UMR5174 EDB (Laboratoire Évolution & Diversité Biologique), Toulouse, France.
Instituto Gulbenkian de Ciência, Oeiras, Portugal.

Jonathan Revah (J)

Cornell Institute of Host-Microbe Interactions and Disease, Department of Entomology, Cornell University, Ithaca, United States.

Xi Liu (X)

Cornell Institute of Host-Microbe Interactions and Disease, Department of Entomology, Cornell University, Ithaca, United States.

Philip Houtz (P)

Cornell Institute of Host-Microbe Interactions and Disease, Department of Entomology, Cornell University, Ithaca, United States.

Nicolas Buchon (N)

Cornell Institute of Host-Microbe Interactions and Disease, Department of Entomology, Cornell University, Ithaca, United States.

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Classifications MeSH