Development of Novel Isoindolone-Based Compounds against Trypanosoma brucei rhodesiense.
T. b. brucei
T. b. rhodesiense
anti-infectives
heterocyclic
in vitro
Journal
ChemistryOpen
ISSN: 2191-1363
Titre abrégé: ChemistryOpen
Pays: Germany
ID NLM: 101594811
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
revised:
02
09
2021
received:
21
07
2021
entrez:
23
9
2021
pubmed:
24
9
2021
medline:
4
1
2022
Statut:
ppublish
Résumé
This study identified the isoindolone ring as a scaffold for novel agents against Trypanosoma brucei rhodesiense and explored the structure-activity relationships of various aromatic ring substitutions. The compounds were evaluated in an integrated in vitro screen. Eight compounds exhibited selective activity against T. b. rhodesiense (IC
Identifiants
pubmed: 34553828
doi: 10.1002/open.202100180
pmc: PMC8459400
doi:
Substances chimiques
Isoindoles
0
Trypanocidal Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
922-927Subventions
Organisme : Fundacão de Amparo à Pesquisa do Estado de São Paulo
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil
ID : 001
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 88881.170193/2018-01
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 2017/22001-0
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 2017/21146-4
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 313834/2018-0
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 428527/2016-7
Informations de copyright
© 2021 The Authors. Published by Wiley-VCH GmbH.
Références
Antimicrob Agents Chemother. 1998 Nov;42(11):2858-62
pubmed: 9797216
Antimicrob Agents Chemother. 2009 Dec;53(12):5197-203
pubmed: 19752271
J Med Chem. 2018 Oct 25;61(20):9287-9300
pubmed: 30234983
Drugs. 2019 Feb;79(2):215-220
pubmed: 30635838
Trop Med Infect Dis. 2020 Feb 05;5(1):
pubmed: 32033395
Eur J Med Chem. 2018 Jan 1;143:306-319
pubmed: 29197735
Nat Commun. 2019 Dec 5;10(1):5564
pubmed: 31804484
Bioorg Med Chem Lett. 2009 Jun 1;19(11):2916-9
pubmed: 19419862
ACS Infect Dis. 2020 Aug 14;6(8):2045-2056
pubmed: 32568511
ChemMedChem. 2021 Mar 18;16(6):966-975
pubmed: 33078573
J Med Chem. 2017 Feb 9;60(3):957-971
pubmed: 27992217
J Biomol Screen. 2015 Jun;20(5):634-45
pubmed: 25690568
ACS Med Chem Lett. 2018 Dec 04;10(1):105-110
pubmed: 30655955
Eur J Med Chem. 2021 Feb 15;212:113101
pubmed: 33385837
ChemistryOpen. 2021 Sep;10(9):922-927
pubmed: 34553828
J Med Chem. 2016 Nov 10;59(21):9686-9720
pubmed: 27548560
Medchemcomm. 2018 Oct 26;9(12):2037-2044
pubmed: 30647879
ACS Med Chem Lett. 2017 Jun 27;8(7):766-770
pubmed: 28740614
Nature. 2016 Sep 8;537(7619):229-233
pubmed: 27501246
J Med Chem. 2014 Aug 14;57(15):6393-402
pubmed: 24978605
J Med Chem. 2005 Aug 25;48(17):5570-9
pubmed: 16107157
Eur J Med Chem. 2020 Feb 15;188:112018
pubmed: 31931339