Se-[(2,2-Dimethyl-1,3-dioxolan-4-yl)methyl] 4-Chlorobenzoselenolate Attenuates Inflammatory Response, Nociception, and Affective Disorders Related to Rheumatoid Arthritis in Mice.

Animals Arthritis, Rheumatoid / drug therapy Freund's Adjuvant / toxicity Humans Inflammation / drug therapy Male Mice Mood Disorders Nociception
affective behaviors antioxidant arthritis hyperalgesia selenium

Journal

ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337

Informations de publication

Date de publication:
06 10 2021
Historique:
pubmed: 24 9 2021
medline: 25 2 2023
entrez: 23 9 2021
Statut: ppublish

Résumé

Despite major advances, not all patients achieve rheumatoid arthritis (RA) remission, thus highlighting a pressing need for new therapeutic treatments. Given this scenario, this study sought to evaluate Se-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl] 4-chlorobenzoselenolate (Se-DMC) potential on a complete Freund's adjuvant (CFA)-induced unilateral arthritis model. The effects of Se-DMC (5 mg/kg; oral dose) and meloxicam (5 mg/kg; oral dose), both administered to animals daily for 14 days, on paw edema, mechanical sensitivity, neurobehavioral deficits (anxiogenic- and depressive-like behaviors), Na

Identifiants

DOI: 10.1021/acschemneuro.1c00512 PMID: 34553902
pubmed: 34553902
doi: 10.1021/acschemneuro.1c00512
doi:

Substances chimiques

Freund's Adjuvant 9007-81-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3760-3771

Auteurs

Ethel A Wilhelm (EA)

Laboratório de Pesquisa em Farmacologia Bioquímica, CCQFA, Universidade Federal de Pelotas, UFPel, Pelotas 96010-900, Brazil.
ORCID: 0000-0002-2875-9962

Paola S Soares (PS)

Laboratório de Pesquisa em Farmacologia Bioquímica, CCQFA, Universidade Federal de Pelotas, UFPel, Pelotas 96010-900, Brazil.

Angélica S Reis (AS)

Laboratório de Pesquisa em Farmacologia Bioquímica, CCQFA, Universidade Federal de Pelotas, UFPel, Pelotas 96010-900, Brazil.

Ketlyn P Motta (KP)

Laboratório de Pesquisa em Farmacologia Bioquímica, CCQFA, Universidade Federal de Pelotas, UFPel, Pelotas 96010-900, Brazil.

Briana B Lemos (BB)

Laboratório de Pesquisa em Farmacologia Bioquímica, CCQFA, Universidade Federal de Pelotas, UFPel, Pelotas 96010-900, Brazil.

William B Domingues (WB)

Programa de Pós-Graduação em Bioquímica e Bioprospecção, Laboratório de Genômica Estrutural, Biotecnologia, Universidade Federal de Pelotas, UFPel, Campus Capão do Leão, Pelotas 96010-900, RS, Brazil.

Eduardo B Blödorn (EB)

Programa de Pós-Graduação em Bioquímica e Bioprospecção, Laboratório de Genômica Estrutural, Biotecnologia, Universidade Federal de Pelotas, UFPel, Campus Capão do Leão, Pelotas 96010-900, RS, Brazil.

Daniela R Araujo (DR)

Laboratório de Síntese Orgânica Limpa, CCQFA, Universidade Federal de Pelotas-UFPel, Pelotas 96010-900, Brazil.

Angelita M Barcellos (AM)

Laboratório de Síntese Orgânica Limpa, CCQFA, Universidade Federal de Pelotas-UFPel, Pelotas 96010-900, Brazil.

Gelson Perin (G)

Laboratório de Síntese Orgânica Limpa, CCQFA, Universidade Federal de Pelotas-UFPel, Pelotas 96010-900, Brazil.
ORCID: 0000-0003-0359-0811

Mauro P Soares (MP)

Laboratório Regional de Diagnóstico, Faculdade de Veterinária, Universidade Federal de Pelotas, UFPel, Pelotas 96010-900, Brazil.

Vinicius F Campos (VF)

Programa de Pós-Graduação em Bioquímica e Bioprospecção, Laboratório de Genômica Estrutural, Biotecnologia, Universidade Federal de Pelotas, UFPel, Campus Capão do Leão, Pelotas 96010-900, RS, Brazil.

Cristiane Luchese (C)

Laboratório de Pesquisa em Farmacologia Bioquímica, CCQFA, Universidade Federal de Pelotas, UFPel, Pelotas 96010-900, Brazil.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Se-[(2,2-Dimethyl-1,3-dioxolan-4-yl)methyl]...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Polyarthrite rhumatoïde › Se-[(2,2-Dimethyl-1,3-dioxolan-4-yl)methyl]...
questionsmedicales.fr › Mélanges complexes › Adjuvant Freund › Se-[(2,2-Dimethyl-1,3-dioxolan-4-yl)methyl]...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Se-[(2,2-Dimethyl-1,3-dioxolan-4-yl)methyl]...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Se-[(2,2-Dimethyl-1,3-dioxolan-4-yl)methyl]...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Se-[(2,2-Dimethyl-1,3-dioxolan-4-yl)methyl]...
questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Se-[(2,2-Dimethyl-1,3-dioxolan-4-yl)methyl]...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Perception › Perception de la douleur › Nociception › Se-[(2,2-Dimethyl-1,3-dioxolan-4-yl)methyl]...