Natural antimicrobial peptides as a source of new antiviral agents.
antiviral
design
library
peptide
virus
Journal
The Journal of general virology
ISSN: 1465-2099
Titre abrégé: J Gen Virol
Pays: England
ID NLM: 0077340
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
entrez:
23
9
2021
pubmed:
24
9
2021
medline:
6
11
2021
Statut:
ppublish
Résumé
Current antiviral drugs are limited because of their adverse side effects and increased rate of resistance. In recent decades, much scientific effort has been invested in the discovery of new synthetic and natural compounds with promising antiviral properties. Among this new generation of compounds, antimicrobial peptides with antiviral activity have been described and are attracting attention due to their mechanism of action and biological properties. To understand the potential of antiviral peptides (AVPs), we analyse the antiviral activity of well-known AVP families isolated from different natural sources, discuss their physical-chemical properties, and demonstrate how AVP databases can guide us to design synthetic AVPs with better therapeutic properties. All considerations in this sphere of antiviral therapy clearly demonstrate the remarkable contribution that AVPs may make in conquering old as well as newly emerging viruses that plague humanity.
Identifiants
pubmed: 34554085
doi: 10.1099/jgv.0.001661
pmc: PMC10026734
doi:
Substances chimiques
Antiviral Agents
0
Pore Forming Cytotoxic Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM138552
Pays : United States
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