Immunological exhaustion: How to make a disparate concept operational?
Journal
PLoS pathogens
ISSN: 1553-7374
Titre abrégé: PLoS Pathog
Pays: United States
ID NLM: 101238921
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
entrez:
23
9
2021
pubmed:
24
9
2021
medline:
27
11
2021
Statut:
epublish
Résumé
In this essay, we show that 3 distinct approaches to immunological exhaustion coexist and that they only partially overlap, generating potential misunderstandings. Exploring cases ranging from viral infections to cancer, we propose that it is crucial, for experimental and therapeutic purposes, to clarify these approaches and their interconnections so as to make the concept of exhaustion genuinely operational.
Identifiants
pubmed: 34555119
doi: 10.1371/journal.ppat.1009892
pii: PPATHOGENS-D-21-00573
pmc: PMC8460019
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1009892Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Diabetes Metab. 2021 May;47(3):101193
pubmed: 33010422
Annu Rev Immunol. 2019 Apr 26;37:457-495
pubmed: 30676822
Nat Rev Immunol. 2020 Sep;20(9):529-536
pubmed: 32728222
Immunity. 2017 Dec 19;47(6):1009-1011
pubmed: 29262341
Cell Mol Immunol. 2016 Nov;13(6):805-815
pubmed: 26412123
J Exp Med. 2012 Dec 17;209(13):2485-99
pubmed: 23230000
J Exp Med. 2014 Aug 25;211(9):1905-18
pubmed: 25113973
Blood. 2013 Feb 28;121(9):1612-21
pubmed: 23247726
Nature. 2019 Jul;571(7764):270-274
pubmed: 31207604
Nat Immunol. 2009 Jan;10(1):29-37
pubmed: 19043418
Cell. 2009 Jul 10;138(1):30-50
pubmed: 19596234
Immunity. 2017 Dec 19;47(6):1114-1128.e6
pubmed: 29221730
J Immunol. 2015 Jun 15;194(12):5801-11
pubmed: 25934860
Science. 2015 Apr 3;348(6230):124-8
pubmed: 25765070
Cell Death Dis. 2015 Jun 18;6:e1792
pubmed: 26086965
Immunol Rev. 2009 May;229(1):114-25
pubmed: 19426218
J Exp Med. 2006 Oct 30;203(11):2461-72
pubmed: 17030951
Annu Rev Immunol. 2008;26:677-704
pubmed: 18173375
Immunity. 2009 Jul 17;31(1):145-57
pubmed: 19604493
Annu Rev Immunol. 2019 Apr 26;37:173-200
pubmed: 30550719
BMC Endocr Disord. 2019 Dec 23;19(1):144
pubmed: 31870373
Nat Rev Immunol. 2020 Feb;20(2):75-76
pubmed: 31925406
Science. 2009 Jun 19;324(5934):1572-6
pubmed: 19443735
Int J Cancer. 2019 Nov 15;145(10):2611-2618
pubmed: 30989643
Nat Commun. 2020 Jul 6;11(1):3434
pubmed: 32632085
Nature. 2019 Jul;571(7764):265-269
pubmed: 31207605
Gastroenterology. 2014 Feb;146(2):550-61
pubmed: 24148617
J Exp Med. 2015 Jun 29;212(7):1125-37
pubmed: 26034050
Front Immunol. 2013 Dec 19;4:455
pubmed: 24391639
J Clin Immunol. 2020 Oct;40(7):974-976
pubmed: 32648027
Immunity. 2016 Aug 16;45(2):358-73
pubmed: 27496729
Immunity. 2016 Jan 19;44(1):179-193
pubmed: 26789923
J Exp Med. 1998 Dec 21;188(12):2205-13
pubmed: 9858507
Nature. 1993 Apr 22;362(6422):758-61
pubmed: 8469287
Immune Netw. 2020 Feb 20;20(1):e2
pubmed: 32158590
J Clin Invest. 2011 Jun;121(6):2350-60
pubmed: 21555851
Immunol Rev. 2010 Jul;236:151-66
pubmed: 20636815
Nat Med. 2010 Oct;16(10):1147-51
pubmed: 20890291
Curr Opin Immunol. 2018 Feb;50:88-93
pubmed: 29253642
Front Immunol. 2013 Dec 20;4:475
pubmed: 24391647
Nat Rev Immunol. 2014 Nov;14(11):768-74
pubmed: 25257362
J Exp Med. 2014 Sep 22;211(10):2047-59
pubmed: 25225458
Eur J Immunol. 2012 Mar;42(3):662-71
pubmed: 22144176
Immunity. 2017 Dec 19;47(6):1129-1141.e5
pubmed: 29246443
Annu Rev Immunol. 2019 Apr 26;37:405-437
pubmed: 30673535
Cell Rep. 2020 Jun 30;31(13):107827
pubmed: 32610128
Immunity. 2016 Aug 16;45(2):415-27
pubmed: 27533016
Blood. 2009 Aug 20;114(8):1528-36
pubmed: 19420358
Science. 2020 Sep 4;369(6508):
pubmed: 32669297
Trends Immunol. 2015 Apr;36(4):265-76
pubmed: 25797516
Nature. 2020 Feb;578(7793):94-101
pubmed: 32025018
Clin Cancer Res. 2018 Sep 1;24(17):4187-4200
pubmed: 29444930
Nat Med. 2006 Nov;12(11):1301-9
pubmed: 17041596
Immunology. 2010 Apr;129(4):474-81
pubmed: 20201977
J Exp Med. 2003 Jul 7;198(1):63-9
pubmed: 12847137
J Theor Biol. 1971 Nov;33(2):379-98
pubmed: 5167514
Nature. 2016 Aug 2;537(7620):412-428
pubmed: 27501245
J Virol. 2003 Apr;77(8):4911-27
pubmed: 12663797
Cancer Med. 2018 Sep;7(9):4517-4529
pubmed: 30088347
Sci Immunol. 2016 Jul 14;1(1):
pubmed: 28239677
Immunity. 2016 Aug 16;45(2):389-401
pubmed: 27521269
J Exp Med. 1998 May 4;187(9):1383-93
pubmed: 9565631
Nat Immunol. 2013 Jun;14(6):603-10
pubmed: 23644506
Nat Immunol. 2013 Nov;14(11):1173-82
pubmed: 24076634
Cell. 2019 Nov 14;179(5):1177-1190.e13
pubmed: 31730856
N Engl J Med. 2017 Dec 21;377(25):2500-2501
pubmed: 29262275
Cell. 2013 Jun 6;153(6):1239-51
pubmed: 23746840
Trends Immunol. 2014 Feb;35(2):51-60
pubmed: 24210163
Nature. 2019 Jul;571(7764):211-218
pubmed: 31207603
Immunol Rev. 2018 May;283(1):99-112
pubmed: 29664577
Nature. 2017 May 4;545(7652):60-65
pubmed: 28397821
Science. 2015 Apr 3;348(6230):69-74
pubmed: 25838375
Nature. 2015 Jul 30;523(7562):612-6
pubmed: 26123020
J Exp Med. 1995 Mar 1;181(3):993-1003
pubmed: 7869056
Proc R Soc Lond B Biol Sci. 1964 Dec 15;161:275-92
pubmed: 14224412
Sci Transl Med. 2015 Mar 25;7(280):280sr1
pubmed: 25810313
Nature. 2016 Sep 15;537(7620):417-421
pubmed: 27501248
Cell Rep. 2020 Jun 23;31(12):107784
pubmed: 32579916
Nat Rev Immunol. 2019 Nov;19(11):665-674
pubmed: 31570879
Nature. 2013 Aug 22;500(7463):415-21
pubmed: 23945592
J Exp Med. 1968 Feb 1;127(2):307-25
pubmed: 5635381
Science. 2012 Nov 30;338(6111):1220-5
pubmed: 23197535
Cell Mol Immunol. 2020 May;17(5):541-543
pubmed: 32203186
Curr Opin Immunol. 2016 Dec;43:74-80
pubmed: 27744240
J Immunol. 2009 Jun 1;182(11):6697-708
pubmed: 19454664
Science. 2016 May 6;352(6286):658-60
pubmed: 27151852
J Clin Invest. 2018 Nov 1;128(11):4884-4897
pubmed: 30130253
Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20453-8
pubmed: 21059929
Immunity. 2016 Jun 21;44(6):1255-69
pubmed: 27332730
Science. 2016 Dec 2;354(6316):1160-1165
pubmed: 27789795
Proc Natl Acad Sci U S A. 2009 May 26;106(21):8623-8
pubmed: 19433785
Science. 2012 Feb 24;335(6071):936-41
pubmed: 22363001
Sci Immunol. 2016 Dec 23;1(6):
pubmed: 28018990
J Clin Invest. 2020 Jun 1;130(6):3137-3150
pubmed: 32125291
Cold Spring Harb Symp Quant Biol. 2013;78:239-47
pubmed: 25028401
J Exp Med. 1968 Oct 1;128(4):715-28
pubmed: 5691983
J Clin Invest. 2019 Jul 22;129(8):3435-3447
pubmed: 31329159