Photo-Crosslinked Gelatin-Based Hydrogel Films to Support Wound Healing.
gelatin-(meth)acrylamide
gelatin-pentenamide
in vitro
mechanical characterization
photo-induced crosslinking
wound healing
Journal
Macromolecular bioscience
ISSN: 1616-5195
Titre abrégé: Macromol Biosci
Pays: Germany
ID NLM: 101135941
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
revised:
30
08
2021
received:
16
06
2021
pubmed:
24
9
2021
medline:
30
3
2022
entrez:
23
9
2021
Statut:
ppublish
Résumé
Gelatin is used widely in the biomedical field, among other for wound healing. Given its upper critical solution temperature, crosslinking is required. To this end, gelatin is chemically modified with different photo-crosslinkable moieties with low (32-34%) and high (63-65%) degree of substitution (DS): gelatin-methacrylamide (gel-MA) and gelatin-acrylamide (gel-AA) and gelatin-pentenamide (gel-PE). Next to the more researched gel-MA, it is especially interesting and novel to compare with other gelatin-derived compounds for the application of wound healing. An additional comparison is made with commercial dressings. The DS is directly proportional to the mechanical characteristics and inversely proportional to the swelling capacity. Gel-PE shows weaker mechanical properties (G' < 15 kPa) than gel-AA and gel-MA (G' < 39 and 45 kPa, respectively). All derivatives are predominantly elastic (recovery indices of 89-94%). Gel-AA and gel-MA show excellent biocompatibility, whereas gel-PE shows a significantly lower initial biocompatibility, evolving positively toward day 7. Overall, gel-MA shows to have the most potential to be applied as wound dressing. Future blending with gel-AA to improve the curing kinetics can lead to dressings able to compete with current commercial dressings.
Identifiants
pubmed: 34555246
doi: 10.1002/mabi.202100246
doi:
Substances chimiques
Biocompatible Materials
0
Methylgalactosides
0
hydrogel film
0
Gelatin
9000-70-8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2100246Informations de copyright
© 2021 Wiley-VCH GmbH.
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