Association analysis of B7-H3 and B7-H4 gene single nucleotide polymorphisms in susceptibility to ankylosing spondylitis in eastern Chinese Han population.
B7-H3
B7-H4
ankylosing spondylitis
haplotype
polymorphisms
Journal
International journal of immunogenetics
ISSN: 1744-313X
Titre abrégé: Int J Immunogenet
Pays: England
ID NLM: 101232337
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
revised:
24
08
2021
received:
16
07
2021
accepted:
09
09
2021
pubmed:
24
9
2021
medline:
14
1
2022
entrez:
23
9
2021
Statut:
ppublish
Résumé
This study was conducted to describe the association between the genetic variation of the recently identified immune checkpoint molecules B7-H3 and B7-H4, and the susceptibility to ankylosing spondylitis (AS). Two single nucleotide polymorphisms (SNPs) of B7-H3 gene and three SNPs of B7-H4 gene were genotyped in 649 AS patients and 646 age- and sex-matched healthy controls. Allele, genotype frequencies and different inheritance models were performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs), and the demographic and clinical parameters of patients were recorded. Our data indicated that B7-H4 rs10801935 and rs3738414 polymorphisms were correlated with AS susceptibility. In the stratification analyses, the minor A allele and GA genotype of B7-H4 rs3738414 increased the risk of AS in male patients (OR = 1.244, 95%CI = 1.026-1.508; OR = 1.453, 95%CI = 1.120-1.886, respectively). However, the association did not reach statistical significance after Bonferroni correction. Furthermore, haplotype analysis revealed that B7-H4 haplotype block TAG was a risk factor for the onset of AS (OR = 1.190, 95%CI = 1.020-1.389). These findings suggested that B7-H4 gene polymorphism may contribute to AS susceptibility in eastern Chinese Han population.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
500-509Subventions
Organisme : the National Natural Science Foundation of China
ID : 81273169
Organisme : the National Natural Science Foundation of China
ID : 81573218
Organisme : the National Natural Science Foundation of China
ID : 81773514
Organisme : the National Natural Science Foundation of China
ID : 82073655
Organisme : the funds for academic and technical leaders in Anhui province
ID : 2017D140
Informations de copyright
© 2021 John Wiley & Sons Ltd.
Références
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