Coronary Microvascular Dysfunction Across the Spectrum of Cardiovascular Diseases: JACC State-of-the-Art Review.
HFpEF
INOCA
MINOCA
angina
coronary flow reserve
coronary microvascular dysfunction
coronary spasm
heart failure
ischemia
ischemic heart disease
microcirculation
microvascular angina
provocative testing
Journal
Journal of the American College of Cardiology
ISSN: 1558-3597
Titre abrégé: J Am Coll Cardiol
Pays: United States
ID NLM: 8301365
Informations de publication
Date de publication:
28 09 2021
28 09 2021
Historique:
received:
08
04
2021
revised:
08
07
2021
accepted:
19
07
2021
entrez:
24
9
2021
pubmed:
25
9
2021
medline:
21
12
2021
Statut:
ppublish
Résumé
Coronary microvascular dysfunction (CMD) encompasses several pathogenetic mechanisms involving coronary microcirculation and plays a major role in determining myocardial ischemia in patients with angina without obstructive coronary artery disease, as well as in several other conditions, including obstructive coronary artery disease, nonischemic cardiomyopathies, takotsubo syndrome, and heart failure, especially the phenotype associated with preserved ejection fraction. Unfortunately, despite the identified pathophysiological and prognostic role of CMD in several conditions, to date, there is no specific treatment for CMD. Due to the emerging role of CMD as common denominator in different clinical phenotypes, additional research in this area is warranted to provide personalized treatments in this "garden variety" of patients. The purpose of this review is to describe the pathophysiological mechanisms of CMD and its mechanistic and prognostic role across different cardiovascular diseases. We will also discuss diagnostic modalities and the potential therapeutic strategies resulting from recent clinical studies.
Identifiants
pubmed: 34556322
pii: S0735-1097(21)05779-X
doi: 10.1016/j.jacc.2021.07.042
pmc: PMC8528638
mid: NIHMS1744119
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1352-1371Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR002649
Pays : United States
Informations de copyright
Copyright © 2021 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Funding Support and Author Disclosures Dr Montone is supported by a Grant for Young Investigators “Ricerca Finalizzata GR-2019-12370197” from the Italian Ministry of Health. Dr Carbone is supported by a Career Development Award 19CDA34660318 from the American Heart Association and by the Clinical and Translational Science Awards Program UL1TR002649 from National Institutes of Health to Virginia Commonwealth University. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
Références
Eur Heart J. 2017 Feb 14;38(7):473-477
pubmed: 27907892
Prog Cardiovasc Dis. 2020 May - Jun;63(3):233-242
pubmed: 32061633
Eur Heart J. 2018 Oct 1;39(37):3439-3450
pubmed: 30165580
Circulation. 2010 Jun 1;121(21):2317-25
pubmed: 20516386
J Am Coll Cardiol. 2014 Aug 12;64(6):541-9
pubmed: 25104521
JACC Heart Fail. 2014 Aug;2(4):358-67
pubmed: 25023822
Eur Heart J. 2014 May;35(17):1101-11
pubmed: 24366916
Lancet. 1998 Apr 18;351(9110):1165-9
pubmed: 9643687
Eur J Heart Fail. 2020 Mar;22(3):432-441
pubmed: 31840366
Circ Res. 2019 Jul 5;125(2):245-258
pubmed: 31268854
Eur Heart J. 2006 Jun;27(12):1408-15
pubmed: 16720691
N Engl J Med. 2003 Sep 11;349(11):1027-35
pubmed: 12968086
Cardiovasc Res. 2017 Sep 01;113(11):1329-1337
pubmed: 28575410
JACC Cardiovasc Interv. 2016 Oct 24;9(20):2172-2174
pubmed: 27765315
JAMA. 2000 Jun 21;283(23):3095-101
pubmed: 10865304
J Am Coll Cardiol. 2006 Mar 7;47(5):1043-8
pubmed: 16516091
J Am Soc Echocardiogr. 2011 Jul;24(7):758-67
pubmed: 21524564
J Am Coll Cardiol. 1991 Mar 15;17(4):879-86
pubmed: 1999624
Cardiovasc Res. 2020 Mar 1;116(4):841-855
pubmed: 31904824
J Am Soc Echocardiogr. 2008 Jan;21(1):72-7
pubmed: 17628401
J Am Coll Cardiol. 2010 Jun 22;55(25):2825-32
pubmed: 20579539
Prog Cardiovasc Dis. 2019 Jul - Aug;62(4):327-333
pubmed: 31442513
JACC Basic Transl Sci. 2019 Sep 04;4(5):575-591
pubmed: 31768475
Circ Heart Fail. 2008 Sep;1(3):161-9
pubmed: 19808286
Circ Cardiovasc Imaging. 2019 Jun;12(6):e009104
pubmed: 31177818
J Nucl Cardiol. 2008 Nov-Dec;15(6):811-7
pubmed: 18984457
J Invasive Cardiol. 2012 Oct;24(10):522-9
pubmed: 23043036
Int J Cardiol. 2018 Jan 1;250:16-20
pubmed: 29031990
Circulation. 1996 Aug 1;94(3):258-65
pubmed: 8759064
Eur Heart J. 2018 Mar 7;39(10):850-852
pubmed: 29346550
J Magn Reson Imaging. 2013 Apr;37(4):865-74
pubmed: 23335425
Eur Heart J. 2018 Mar 7;39(10):840-849
pubmed: 29293969
Cardiovasc Res. 2020 Mar 1;116(4):741-755
pubmed: 32034397
Free Radic Biol Med. 2017 Aug;109:33-47
pubmed: 28274817
Prog Cardiovasc Dis. 2019 Jul - Aug;62(4):315-326
pubmed: 30922976
Biomed Res Int. 2014;2014:193095
pubmed: 24734227
Future Cardiol. 2021 Jan;17(1):149-154
pubmed: 32628045
Circulation. 2014 Jun 17;129(24):2518-27
pubmed: 24787469
N Engl J Med. 2019 Oct 24;381(17):1609-1620
pubmed: 31475794
J Am Coll Cardiol. 2013 Feb 12;61(6):615-21
pubmed: 23290547
Clin Physiol Funct Imaging. 2009 Nov;29(6):447-52
pubmed: 19712079
Circulation. 1995 Apr 1;91(7):1944-51
pubmed: 7895351
Clin Cardiol. 2011 Aug;34(8):483-7
pubmed: 21780138
J Am Coll Cardiol. 2014 Jan 21;63(2):103-9
pubmed: 24201078
JACC Heart Fail. 2013 Apr;1(2):115-22
pubmed: 24621836
Cardiovasc Res. 2020 Mar 1;116(4):806-816
pubmed: 31999329
J Mol Cell Cardiol. 2012 Apr;52(4):794-801
pubmed: 22004900
Circ Cardiovasc Interv. 2019 Sep;12(9):e007889
pubmed: 31525096
Am J Cardiol. 2002 Nov 1;90(9):974-82
pubmed: 12398965
J Am Coll Cardiol. 2018 Oct 16;72(16):1955-1971
pubmed: 30309474
Eur Heart J. 2010 Jun;31(11):1319-27
pubmed: 20215125
Circulation. 1995 Aug 15;92(4):796-804
pubmed: 7641359
N Engl J Med. 1994 Jun 23;330(25):1782-8
pubmed: 8190154
Eur Heart J. 2015 Dec 1;36(45):3134-46
pubmed: 26112888
N Engl J Med. 2007 Feb 22;356(8):830-40
pubmed: 17314342
Eur Heart J. 2021 Jul 8;42(26):2590-2604
pubmed: 33257973
Eur Heart J Cardiovasc Imaging. 2021 Jun 22;22(7):790-799
pubmed: 32514567
Circulation. 2017 Feb 21;135(8):724-735
pubmed: 28052977
JACC Cardiovasc Imaging. 2019 Oct;12(10):1958-1969
pubmed: 30772231
Ann Intern Med. 1999 Dec 7;131(11):838-41
pubmed: 10610629
Circulation. 2002 Apr 2;105(13):1545-7
pubmed: 11927519
Circ Cardiovasc Interv. 2018 Mar;11(3):e006194
pubmed: 29870386
Nature. 1999 Nov 18;402(6759):309-13
pubmed: 10580504
J Am Coll Cardiol. 2019 May 7;73(17):2209-2225
pubmed: 31047010
Int J Cardiol. 2015 Apr 15;185:229-35
pubmed: 25802037
Clin Res Cardiol. 2014 Jan;103(1):11-9
pubmed: 23995322
J Nucl Med. 2008 Apr;49(4):564-72
pubmed: 18344444
Radiology. 2001 Jun;219(3):637-43
pubmed: 11376247
J Am Coll Cardiol. 2008 Mar 18;51(11):1060-5
pubmed: 18342222
J Am Coll Cardiol. 2003 Jan 1;41(1):15-9
pubmed: 12570938
Heart. 2006 Mar;92(3):357-60
pubmed: 16085718
J Card Fail. 2019 Oct;25(10):843-845
pubmed: 31487534
Am Heart J. 2011 Oct;162(4):678-84
pubmed: 21982660
Circulation. 2015 Feb 10;131(6):550-9
pubmed: 25552356
Front Endocrinol (Lausanne). 2020 Sep 30;11:558271
pubmed: 33117276
Circulation. 2018 Oct 2;138(14):1463-1480
pubmed: 30354347
Circulation. 2015 Jan 6;131(1):19-27
pubmed: 25400060
Am J Physiol Heart Circ Physiol. 2018 May 1;314(5):H1033-H1042
pubmed: 29424571
Circulation. 2013 Jun 18;127(24):2436-41
pubmed: 23681066
Circulation. 2003 Jul 1;107(25):3129-32
pubmed: 12821539
Circ Cardiovasc Interv. 2015 Aug;8(8):e002443
pubmed: 26245891
J Am Heart Assoc. 2019 Jul 16;8(14):e011990
pubmed: 31284804
J Card Fail. 2020 Nov;26(11):1016-1021
pubmed: 32846205
Circulation. 2004 Nov 2;110(18):2889-95
pubmed: 15505103
J Am Coll Cardiol. 2018 Dec 11;72(23 Pt A):2841-2855
pubmed: 30266608
Circ Res. 2009 Mar 27;104(6):780-6
pubmed: 19179657
Atherosclerosis. 2017 Sep;264:115-121
pubmed: 28526473
Circulation. 2018 Jan 9;137(2):148-161
pubmed: 28993402
Eur J Heart Fail. 2013 Dec;15(12):1363-73
pubmed: 23818648
Heart Fail Clin. 2020 Jan;16(1):71-80
pubmed: 31735317
Atherosclerosis. 2021 Feb;318:14-21
pubmed: 33360263
Cardiovasc Diabetol. 2019 Feb 7;18(1):16
pubmed: 30732594
Prog Cardiovasc Dis. 2020 Sep - Oct;63(5):570-584
pubmed: 32387101
Circ Cardiovasc Imaging. 2015 Apr;8(4):
pubmed: 25801710
Eur J Heart Fail. 2021 May;23(5):765-772
pubmed: 32949186
Eur Heart J. 2018 Jan 7;39(2):91-98
pubmed: 29228159
J Am Coll Cardiol. 1993 Mar 1;21(3):612-21
pubmed: 8436742
Mayo Clin Proc. 2018 Nov;93(11):1629-1647
pubmed: 30392544
Int J Cardiol. 2013 Jul 31;167(2):335-41
pubmed: 22889703
Eur J Heart Fail. 2013 Sep;15(9):1062-73
pubmed: 23563576
Atherosclerosis. 2011 Apr;215(2):500-6
pubmed: 21315354
Heart. 2020 Jun;106(12):923-930
pubmed: 31924712
J Am Coll Cardiol. 2013 Jul 23;62(4):263-71
pubmed: 23684677
N Engl J Med. 2017 Mar 2;376(9):897
pubmed: 28249128
J Am Coll Cardiol. 2018 Nov 27;72(21):2625-2641
pubmed: 30466521
Circulation. 1997 Nov 18;96(10):3369-77
pubmed: 9396429
Circulation. 2017 Jun 13;135(24):2426-2441
pubmed: 28606950
Eur Heart J Cardiovasc Pharmacother. 2015 Jan;1(1):65-71
pubmed: 27533969
Circ Cardiovasc Interv. 2019 Aug;12(8):e007547
pubmed: 31416359
J Am Heart Assoc. 2018 Feb 27;7(5):
pubmed: 29487111
JACC Cardiovasc Imaging. 2010 Jun;3(6):623-40
pubmed: 20541718
Am J Transplant. 2015 May;15(5):1400-6
pubmed: 25766634
Cardiovasc Diagn Ther. 2017 Oct;7(5):452-462
pubmed: 29255689