High levels of osteoprotegerin are associated with coronary artery calcification in patients suspected of a chronic coronary syndrome.
Aged
Biomarkers
/ blood
Chronic Disease
Coronary Artery Disease
/ blood
Coronary Vessels
/ diagnostic imaging
Extracellular Vesicles
/ metabolism
Female
Humans
Male
Middle Aged
Myocardial Perfusion Imaging
Osteoprotegerin
/ blood
Prospective Studies
Retrospective Studies
Risk Assessment
/ methods
Risk Factors
Syndrome
Vascular Calcification
/ blood
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
23 09 2021
23 09 2021
Historique:
received:
31
03
2021
accepted:
03
06
2021
entrez:
24
9
2021
pubmed:
25
9
2021
medline:
25
12
2021
Statut:
epublish
Résumé
Plasma osteoprotegerin (OPG) and vascular smooth muscle cell (VSMC) derived extracellular vesicles (EVs) are important regulators in the process of vascular calcification (VC). In population studies, high levels of OPG are associated with events. In animal studies, however, high OPG levels result in reduction of VC. VSMC-derived EVs are assumed to be responsible for OPG transport and VC but this role has not been studied. For this, we investigated the association between OPG in plasma and circulating EVs with coronary artery calcium (CAC) as surrogate for VC in symptomatic patients. We retrospectively assessed 742 patients undergoing myocardial perfusion imaging (MPI). CAC scores were determined on the MPI-CT images using a previously developed automated algorithm. Levels of OPG were quantified in plasma and two EV-subpopulations (LDL and TEX), using an electrochemiluminescence immunoassay. Circulating levels of OPG were independently associated with CAC scores in plasma; OR 1.39 (95% CI 1.17-1.65), and both EV populations; EV-LDL; OR 1.51 (95% CI 1.27-1.80) and EV-TEX; OR 1.21 (95% CI 1.02-1.42). High levels of OPG in plasma were independently associated with CAC scores in this symptomatic patient cohort. High levels of EV-derived OPG showed the same positive association with CAC scores, suggesting that EV-derived OPG mirrors the same pathophysiological process as plasma OPG.
Identifiants
pubmed: 34556709
doi: 10.1038/s41598-021-98177-4
pii: 10.1038/s41598-021-98177-4
pmc: PMC8460823
doi:
Substances chimiques
Biomarkers
0
Osteoprotegerin
0
TNFRSF11B protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
18946Informations de copyright
© 2021. The Author(s).
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