Biotite-Calx Based Traditional Indian Medicine
Sahastraputi-Abhrak-Bhasma
asthma
cytokine
lung inflammation
mica-medicine
physicochemical analysis
Journal
Journal of inflammation research
ISSN: 1178-7031
Titre abrégé: J Inflamm Res
Pays: New Zealand
ID NLM: 101512684
Informations de publication
Date de publication:
2021
2021
Historique:
received:
07
04
2021
accepted:
25
08
2021
entrez:
24
9
2021
pubmed:
25
9
2021
medline:
25
9
2021
Statut:
epublish
Résumé
Asthma is a heterogeneous airway inflammatory disease with limited therapeutic options. Traditional medicine is extensively used for treating various ailments including asthma. We have tested for the anti-inflammatory and anti-asthmatic properties of SPAB, using a mouse model of ovalbumin-induced allergic asthma in-vivo and cell-based assays in-vitro. Histological analysis, qPCR and ELISA were performed to assess the pathology. SEM, EDX and XRD-analysis were performed to characterize the SPAB particles. SEM, EDX and XRD-analysis identified the presence of SPAB particle of 100 nm-~1µm diameter and contains annite-1M, aluminium silicate, kyanite, aluminium oxide, magnesium silicate, and maghemite in the samples. Ova-challenge resulted in severe inflammatory responses, airway remodelling and increased oxidative burden in lungs. Importantly, prophylactic treatment with SPAB significantly attenuated allergen induced leukocyte infiltration specifically eosinophils, lymphocytes, macrophages and neutrophils in BALF. Ova-induced mucus hypersecretion, peri-bronchial collagen deposition, inflammatory cell infiltration and bronchial epithelial thickening were significantly abrogated upon SPAB treatment. qPCR and ELISA analysis identified that allergen induced increases in Taken together, our results experimentally validated the prophylactic ameliorative potential of the Indian classical medicine
Identifiants
pubmed: 34557016
doi: 10.2147/JIR.S313955
pii: 313955
pmc: PMC8455516
doi:
Types de publication
Journal Article
Langues
eng
Pagination
4743-4760Informations de copyright
© 2021 Balkrishna et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
Références
Anal Biochem. 1971 Nov;44(1):276-87
pubmed: 4943714
J Vet Med Sci. 2015 Sep;77(9):1087-94
pubmed: 25947887
FASEB J. 2016 Jul;30(7):2615-26
pubmed: 27059719
Biol Trace Elem Res. 2006 Mar;109(3):231-54
pubmed: 16632893
J Ayurveda Integr Med. 2020 Jul - Sep;11(3):236-242
pubmed: 30826258
J Clin Invest. 1999 Mar;103(6):779-88
pubmed: 10079098
An Acad Bras Cienc. 2013 Mar;85(1):137-46
pubmed: 23460424
Part Fibre Toxicol. 2009 Dec 22;6:34
pubmed: 20028532
Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S35-9
pubmed: 27027950
J Nanobiotechnology. 2020 Feb 18;18(1):33
pubmed: 32070362
Phytomedicine. 2020 Nov;78:153295
pubmed: 32795904
Clin Chim Acta. 1991 Feb 15;196(2-3):143-51
pubmed: 2029780
Nat Med. 2012 May 04;18(5):736-49
pubmed: 22561837
Indian J Exp Biol. 2001 Oct;39(10):1022-7
pubmed: 11883510
J Adv Pharm Technol Res. 2014 Jan;5(1):4-12
pubmed: 24696811
Clin Exp Allergy. 2002 Jul;32(7):1104-11
pubmed: 12100061
J Leukoc Biol. 1992 Dec;52(6):619-24
pubmed: 1334501
World Allergy Organ J. 2011 Oct;4(10):151-8
pubmed: 23268432
Nat Rev Immunol. 2014 Oct;14(10):686-98
pubmed: 25234144
J Vet Sci. 2013;14(2):135-41
pubmed: 23814470
Am J Physiol Lung Cell Mol Physiol. 2015 Aug 1;309(3):L293-304
pubmed: 26024894
Anal Biochem. 1983 Jul 15;132(2):345-52
pubmed: 6312841
Annu Rev Pharmacol Toxicol. 2014;54:165-84
pubmed: 24111540
Biomed Pharmacother. 2020 Jun;126:110063
pubmed: 32145582
J Allergy Clin Immunol. 2013 May;131(5):1267-74; quiz 1275
pubmed: 23541326
Toxicol Pathol. 2012 Jun;40(4 Suppl):7S-13S
pubmed: 22637736
Nat Med. 2012 May 04;18(5):716-25
pubmed: 22561835
Neuropharmacology. 2011 Jan;60(1):3-6
pubmed: 20709088
Immunity. 2019 Apr 16;50(4):975-991
pubmed: 30995510
Anal Biochem. 1976 Jul;74(1):214-26
pubmed: 962076
Arch Biochem Biophys. 1968 Apr;125(1):189-98
pubmed: 5655425
J Immunol Methods. 1990 Jan 24;126(1):125-33
pubmed: 2154520
Anc Sci Life. 2012 Apr;31(4):171-80
pubmed: 23661864
J Basic Clin Pharm. 2016 Mar;7(2):27-31
pubmed: 27057123
Evid Based Complement Alternat Med. 2019 Jan 10;2019:1697804
pubmed: 30941186
J Ayurveda Integr Med. 2020 Apr - Jun;11(2):118-123
pubmed: 30391122
Science. 1973 Feb 9;179(4073):588-90
pubmed: 4686466
J Ethnopharmacol. 2014 Sep 11;155(2):1001-10
pubmed: 24993885
Nat Immunol. 2015 Jan;16(1):45-56
pubmed: 25521684
Thorax. 2000 Nov;55(11):925-9
pubmed: 11050261
Science. 1983 Apr 29;220(4596):472-7
pubmed: 6836290
Am J Respir Cell Mol Biol. 2010 Mar;42(3):268-75
pubmed: 19520914
Inflamm Allergy Drug Targets. 2006 Dec;5(4):253-6
pubmed: 17168796
Biomolecules. 2020 Apr 13;10(4):
pubmed: 32295034
BMC Vet Res. 2014 Aug 12;10:179
pubmed: 25255918
Toxicol Pathol. 2002 Jan-Feb;30(1):93-6
pubmed: 11890482
Nat Rev Immunol. 2015 Jan;15(1):57-65
pubmed: 25534623
J Allergy Clin Immunol. 2012 Jan;129(1):48-59
pubmed: 22196524
Front Immunol. 2019 Mar 04;10:364
pubmed: 30886621
J Vet Sci. 2014;15(3):443-7
pubmed: 24690605
Adv Sci (Weinh). 2019 Aug 20;6(19):1901211
pubmed: 31592423