Simulating CXCR5 Dynamics in Complex Tissue Microenvironments.
B cells
G-protein coupled receptors
chemokines
mathematical modelling
systems biology
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
30
04
2021
accepted:
16
08
2021
entrez:
24
9
2021
pubmed:
25
9
2021
medline:
18
12
2021
Statut:
epublish
Résumé
To effectively navigate complex tissue microenvironments, immune cells sense molecular concentration gradients using G-protein coupled receptors. However, due to the complexity of receptor activity, and the multimodal nature of chemokine gradients
Identifiants
pubmed: 34557191
doi: 10.3389/fimmu.2021.703088
pmc: PMC8452942
doi:
Substances chimiques
CXCR5 protein, human
0
Receptors, CXCR5
0
Receptors, Chemokine
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
703088Subventions
Organisme : Wellcome Trust
ID : 204829
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT0905024MA
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K021125/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0601156
Pays : United Kingdom
Informations de copyright
Copyright © 2021 Cosgrove, Alden, Stein, Coles and Timmis.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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