The PNPLA3 rs738409 Variant but not MBOAT7 rs641738 is a Risk Factor for Nonalcoholic Fatty Liver Disease in Obese U.S. Children of Hispanic Ethnicity.
Hispanic Americans
Lipid metabolism
Nonalcoholic fatty liver disease
Pediatric obesity
Polymorphism, genetic
Journal
Pediatric gastroenterology, hepatology & nutrition
ISSN: 2234-8646
Titre abrégé: Pediatr Gastroenterol Hepatol Nutr
Pays: Korea (South)
ID NLM: 101590471
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
01
03
2021
revised:
25
06
2021
accepted:
17
07
2021
entrez:
24
9
2021
pubmed:
25
9
2021
medline:
25
9
2021
Statut:
ppublish
Résumé
The rs641738 C>T in membrane-bound O-acyltransferase domain-containing protein 7 (MBOAT7) is implicated, along with the rs738409 C>G polymorphism in patatin-like phospholipase domain-containing protein 3 (PNPLA3), in nonalcoholic fatty liver disease (NAFLD). The association of these polymorphisms and NAFLD are investigated in Hispanic children with obesity. Obese children with and without NAFLD were enrolled at a pediatric tertiary care health system and genotyped for MBOAT7 rs641738 C>T and PNPLA3 rs738409 C>G. NAFLD was characterized by the ultrasonographic presence of hepatic steatosis along with persistently elevated liver enzymes. Genetic variants and demographic and biochemical data were analyzed for the effects on NAFLD. Among 126 enrolled subjects, 84 in the case group had NAFLD and 42 in the control group did not. The two groups had similar demographic distribution. NAFLD was associated with abnormal liver enzymes and elevated triglycerides and cholesterol ( In Hispanic children with obesity, PNPLA3 rs738409 C>G polymorphism increased the risk for NAFLD. The role of MBOAT7 rs641738 variant in NAFLD is less evident.
Identifiants
pubmed: 34557398
doi: 10.5223/pghn.2021.24.5.455
pmc: PMC8443857
doi:
Types de publication
Journal Article
Langues
eng
Pagination
455-469Informations de copyright
Copyright © 2021 by The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition.
Déclaration de conflit d'intérêts
Conflict of Interest: The authors have no financial conflicts of interest.
Références
Ann Hepatol. 2018 Mar 1;17(2):250-255
pubmed: 29469042
Gastroenterology. 2007 Dec;133(6):1814-20
pubmed: 18054554
J Pediatr Gastroenterol Nutr. 2018 Jul;67(1):69-74
pubmed: 29601441
BMC Med Genet. 2010 Dec 22;11:172
pubmed: 21176169
Nat Genet. 2015 Dec;47(12):1443-8
pubmed: 26482880
Pediatrics. 2006 Oct;118(4):1388-93
pubmed: 17015527
Aliment Pharmacol Ther. 2015 Jul;42(1):99-105
pubmed: 25939720
Pediatr Res. 2016 Nov;80(5):651-655
pubmed: 27411039
Hepatol Commun. 2018 May 04;2(7):807-820
pubmed: 30027139
Pediatr Res. 2019 Apr;85(5):671-677
pubmed: 30710115
Liver Int. 2018 Jul;38(7):1300-1307
pubmed: 29314568
Sci Rep. 2018 Mar 23;8(1):5097
pubmed: 29572551
J Lipid Res. 2017 Jan;58(1):247-255
pubmed: 27836992
Biomed Rep. 2014 Sep;2(5):633-636
pubmed: 25054002
Gastroenterology. 2016 May;150(5):1219-1230.e6
pubmed: 26850495
Hepatology. 2005 Jun;41(6):1313-21
pubmed: 15915461
Hepatology. 2018 Oct;68(4):1376-1390
pubmed: 29665034
Int J Mol Sci. 2018 Mar 19;19(3):
pubmed: 29562725
J Gastroenterol Hepatol. 2012 May;27(5):951-6
pubmed: 22141340
Am J Gastroenterol. 2018 Mar;113(3):376-383
pubmed: 29485130
J Pediatr. 2011 May;158(5):740-4
pubmed: 21168155
Cell Mol Life Sci. 2018 Sep;75(18):3313-3327
pubmed: 29936596
J Clin Gastroenterol. 2018 Apr;52(4):339-346
pubmed: 28961576
J Clin Endocrinol Metab. 2006 Dec;91(12):4753-61
pubmed: 16968800
J Pediatr. 2017 Nov;190:100-107.e2
pubmed: 28918882
Clin Gastroenterol Hepatol. 2013 Sep;11(9):1183-1190.e2
pubmed: 23416328
Diabetes Care. 2013 May;36(5):1353-60
pubmed: 23275357
World J Gastroenterol. 2014 Jun 21;20(23):7347-55
pubmed: 24966605
Int J Mol Sci. 2019 Mar 14;20(6):
pubmed: 30875804
Nat Genet. 2008 Dec;40(12):1461-5
pubmed: 18820647
Dig Dis Sci. 2008 May;53(5):1358-63
pubmed: 18347982
Gastroenterology. 2015 Dec;149(7):1784-93
pubmed: 26299412
PLoS One. 2015 Oct 29;10(10):e0140908
pubmed: 26512983
J Gastroenterol Hepatol. 2018 Jun;33(6):1277-1285
pubmed: 29193269
Ann Hepatol. 2017 Oct 16;16(6):909-915
pubmed: 29055919
Hepatology. 2010 Oct;52(4):1281-90
pubmed: 20803499
PLoS One. 2018 Jan 31;13(1):e0185490
pubmed: 29385134