Increased Autoantibodies Against Ro/SS-A, CENP-B, and La/SS-B in Patients With Kidney Allograft Antibody-mediated Rejection.
Journal
Transplantation direct
ISSN: 2373-8731
Titre abrégé: Transplant Direct
Pays: United States
ID NLM: 101651609
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
11
06
2021
accepted:
02
07
2021
entrez:
24
9
2021
pubmed:
25
9
2021
medline:
25
9
2021
Statut:
epublish
Résumé
Antibody-mediated rejection (AMR) causes more than 50% of late kidney graft losses. In addition to anti-human leukocyte antigen (HLA) donor-specific antibodies, antibodies against non-HLA antigens are also linked to AMR. Identifying key non-HLA antibodies will improve our understanding of AMR. We analyzed non-HLA antibodies in sera from 80 kidney transplant patients with AMR, mixed rejection, acute cellular rejection (ACR), or acute tubular necrosis. IgM and IgG antibodies against 134 non-HLA antigens were measured in serum samples collected pretransplant or at the time of diagnosis. Fifteen non-HLA antibodies were significantly increased ( This is the first study implicating autoantibodies anti-Ro/SS-A and anti-CENP-B in AMR. These antibodies may participate in the crosstalk between autoimmunity and alloimmunity in kidney AMR.
Identifiants
pubmed: 34557585
doi: 10.1097/TXD.0000000000001215
pmc: PMC8454907
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e768Informations de copyright
Copyright © 2021 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc.
Déclaration de conflit d'intérêts
I.J. reports receiving personal fees from Canadian Rheumatology Association, grants and nonfinancial support from IBM, and personal fees from Novartis, outside the submitted work. The other authors declare no conflicts of interest.
Références
J Am Soc Nephrol. 2017 Feb;28(2):400-406
pubmed: 27798244
Transpl Immunol. 2019 Feb;52:53-56
pubmed: 30458294
Transplantation. 2010 May 27;89(10):1239-46
pubmed: 20445487
N Engl J Med. 2005 May 12;352(19):2027-8; author reply 2027-8
pubmed: 15888709
Curr Opin Organ Transplant. 2010 Aug;15(4):456-61
pubmed: 20616728
Ann Rheum Dis. 2006 Aug;65(8):1028-32
pubmed: 16414973
Immunology. 2010 Jul;130(3):427-35
pubmed: 20201985
Methods Mol Biol. 2013;1034:41-70
pubmed: 23775730
Am J Transplant. 2018 Feb;18(2):293-307
pubmed: 29243394
Curr Opin Organ Transplant. 2017 Feb;22(1):8-13
pubmed: 28005572
Immunol Res. 2005;33(3):195-212
pubmed: 16461998
J Rheumatol. 2012 Apr;39(4):787-94
pubmed: 22467948
Arthritis Rheum. 2005 Sep;52(9):2645-55
pubmed: 16142722
Transplant Proc. 1999 Feb-Mar;31(1-2):100-1
pubmed: 10083028
Am J Transplant. 2013 Apr;13(4):861-874
pubmed: 23432943
J Am Soc Nephrol. 2020 Nov;31(11):2705-2724
pubmed: 32900843
Transpl Immunol. 2018 Feb;46:29-35
pubmed: 29217423
Am J Transplant. 2012 Feb;12(2):388-99
pubmed: 22081892
J Thromb Haemost. 2017 May;15(5):1020-1031
pubmed: 28239987
Curr Opin Organ Transplant. 2014 Feb;19(1):33-40
pubmed: 24316758
Nat Rev Nephrol. 2019 Jan;15(1):11-26
pubmed: 30443016
Clin Chim Acta. 2011 Oct 9;412(21-22):1937-43
pubmed: 21756890
J Autoimmun. 2012 Aug;39(1-2):77-82
pubmed: 22402340
Am J Transplant. 2019 Oct;19(10):2692-2704
pubmed: 31062482
J Hepatol. 2014 Jan;60(1):210-23
pubmed: 24084655
Kidney Int. 2011 Mar;79(6):655-662
pubmed: 20980975
Scand J Immunol. 2002 Nov;56(5):456-69
pubmed: 12410795
J Immunol. 1989 Jun 1;142(11):3815-20
pubmed: 2715637
PLoS One. 2016 Mar 11;11(3):e0151224
pubmed: 26967734
Front Pharmacol. 2018 Jun 26;9:642
pubmed: 29997500
J Am Soc Nephrol. 2019 Apr;30(4):692-709
pubmed: 30850439
Arthritis Rheum. 2002 Jul;46(7):1866-72
pubmed: 12124871
Hum Immunol. 2019 Aug;80(8):602-607
pubmed: 30926354
Transplantation. 2008 Sep 15;86(5):681-5
pubmed: 18791449
Exp Ther Med. 2017 Jun;13(6):2616-2622
pubmed: 28587321
Clin Exp Rheumatol. 2004 May-Jun;22(3):285-92
pubmed: 15144121
Rheumatol Int. 2017 Aug;37(8):1323-1333
pubmed: 28417151
J Biol Chem. 2011 Oct 21;286(42):36478-91
pubmed: 21862588
Immunol Lett. 2020 May;221:1-5
pubmed: 32057908
Kidney Int. 2012 Apr;81(7):628-39
pubmed: 22297669
Kidney Int. 2018 Jan;93(1):260-269
pubmed: 28927645
J Immunol. 2018 Apr 1;200(7):2372-2390
pubmed: 29475988
Annu Rev Immunol. 1993;11:729-66
pubmed: 7682817
Am J Transplant. 2005 Feb;5(2):383-93
pubmed: 15643999
Arthritis Rheum. 1986 Feb;29(2):196-206
pubmed: 3485431
N Engl J Med. 2019 May 16;380(20):1918-1928
pubmed: 31091373
J Immunol. 1999 Jan 1;162(1):577-84
pubmed: 9886435
Am J Pathol. 2013 Nov;183(5):1364-1374
pubmed: 24007883
J Clin Invest. 2017 Jun 30;127(7):2492-2504
pubmed: 28604384
PLoS One. 2016 Sep 15;11(9):e0162942
pubmed: 27631127
Am J Transplant. 2014 Mar;14(3):685-93
pubmed: 24410875
RMD Open. 2020 Jun;6(2):
pubmed: 32540951
Sci Transl Med. 2015 Dec 16;7(318):318ra200
pubmed: 26676607
Cell Stress Chaperones. 2017 May;22(3):319-343
pubmed: 28409327
Nat Rev Nephrol. 2016 Nov;12(11):678-691
pubmed: 27641135
Am J Reprod Immunol. 1992 Oct-Dec;28(3-4):256-8
pubmed: 1285896
Sci Rep. 2019 May 10;9(1):7203
pubmed: 31076589
Hum Immunol. 2019 Aug;80(8):608-613
pubmed: 31029511
Cell Rep. 2016 Nov 22;17(9):2394-2404
pubmed: 27880912
Matrix Biol. 2018 Aug;68-69:150-166
pubmed: 29475023
Hum Immunol. 2013 Nov;74(11):1478-85
pubmed: 23876679
Arthritis Rheum. 2009 Sep;60(9):2805-16
pubmed: 19714638
J Immunol. 1990 Apr 1;144(7):2647-52
pubmed: 1690773
Am J Transplant. 2020 Mar;20(3):726-738
pubmed: 31729155
J Assoc Physicians India. 2002 Jun;50:762-5
pubmed: 12240838
Trends Immunol. 2017 Dec;38(12):916-926
pubmed: 28807517
Cell Death Dis. 2019 Mar 8;10(3):235
pubmed: 30850581
J Autoimmun. 1997 Feb;10(1):67-75
pubmed: 9080301
N Engl J Med. 2005 Feb 10;352(6):558-69
pubmed: 15703421
Healthc Manage Forum. 2014 Spring;27(1):30-6
pubmed: 25109135
Clin Rheumatol. 1995 Jul;14 Suppl 1:11-6
pubmed: 7493450
Rinsho Byori. 1996 Sep;44(9):877-82
pubmed: 8911074
Joint Bone Spine. 2003 Jun;70(3):187-94
pubmed: 12814761
Arthritis Rheum. 2007 Nov;56(11):3814-26
pubmed: 17968937
Circ Res. 2012 Jan 6;110(1):94-104
pubmed: 22076637
Nat Rev Nephrol. 2016 Aug;12(8):484-95
pubmed: 27345243
Stat Med. 2019 Feb 10;38(3):363-375
pubmed: 30298671
Am J Transplant. 2019 Mar;19(3):699-712
pubmed: 30129231
Ann Lab Med. 2018 Sep;38(5):450-457
pubmed: 29797816
Clin Lab Med. 2019 Mar;39(1):87-106
pubmed: 30709511
J Am Soc Nephrol. 2018 Jun;29(6):1761-1770
pubmed: 29602833
Hum Immunol. 2013 Nov;74(11):1459-62
pubmed: 23777935
Kidney Int. 2019 Jul;96(1):189-201
pubmed: 31005275
Nephrol Dial Transplant. 2015 Oct;30(10):1622-30
pubmed: 25538161
Am J Transplant. 2013 Oct;13(10):2577-89
pubmed: 23941128
Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18889-94
pubmed: 19028871
J Immunol Res. 2017;2017:7903471
pubmed: 28373996