Programmed surface on poly(aryl-ether-ether-ketone) initiating immune mediation and fulfilling bone regeneration sequentially.
bone regeneration
immune-mediated osteogenesis
poly(aryl-ether-ether-ketone)
sequential release
surface modifications
Journal
Innovation (Cambridge (Mass.))
ISSN: 2666-6758
Titre abrégé: Innovation (Camb)
Pays: United States
ID NLM: 101771342
Informations de publication
Date de publication:
28 Aug 2021
28 Aug 2021
Historique:
received:
27
04
2021
accepted:
26
07
2021
entrez:
24
9
2021
pubmed:
25
9
2021
medline:
25
9
2021
Statut:
epublish
Résumé
The immune responses are involved in every stage after implantation but the reported immune-regulated materials only work at the beginning without fully considering the different phases of bone healing. Here, poly(aryl-ether-ether-ketone) (PEEK) is coated with a programmed surface, which rapidly releases interleukin-10 (IL-10) in the first week and slowly delivers dexamethasone (DEX) up to 4 weeks. Owing to the synergistic effects of IL-10 and DEX, an aptly weak inflammation is triggered within the first week, followed by significant M2 polarization of macrophages and upregulation of the autophagy-related factors. The suitable immunomodulatory activities pave the way for osteogenesis and the steady release of DEX facilitates bone regeneration thereafter. The sequential immune-mediated process is also validated by an 8-week implementation on a rat model. This is the first attempt to construct implants by taking advantage of both immune-mediated modulation and sequential regulation spanning all bone regeneration phases, which provides insights into the fabrication of advanced biomaterials for tissue engineering and immunological therapeutics.
Identifiants
pubmed: 34557785
doi: 10.1016/j.xinn.2021.100148
pii: S2666-6758(21)00073-4
pmc: PMC8454576
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100148Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no competing interests.
Références
Biomaterials. 2015 May;51:173-183
pubmed: 25771008
Biomaterials. 2010 May;31(13):3465-70
pubmed: 20153890
Calcif Tissue Int. 2006 Aug;79(2):118-25
pubmed: 16927049
Knee. 2007 Dec;14(6):458-64
pubmed: 17869519
J Biomed Mater Res A. 2004 Aug 1;70(2):194-205
pubmed: 15227664
Biomaterials. 2012 May;33(15):3792-802
pubmed: 22386919
Biomaterials. 2011 Oct;32(28):6692-709
pubmed: 21715002
Bone. 2018 Jan;106:78-89
pubmed: 26529389
Biotechnol Bioeng. 2014 Jun;111(6):1210-21
pubmed: 24375008
Acta Biomater. 2009 Feb;5(2):776-84
pubmed: 18951072
Nat Mater. 2009 Jul;8(7):543-57
pubmed: 19525947
Biomaterials. 2014 Nov;35(33):9041-8
pubmed: 25109440
Innovation (Camb). 2020 Aug 10;1(2):100040
pubmed: 34557713
Front Immunol. 2019 Dec 13;10:2925
pubmed: 31921183
Regen Biomater. 2020 Jun;7(3):233-245
pubmed: 32523726
Biomaterials. 2018 May;164:22-37
pubmed: 29482061
J Am Chem Soc. 2009 Mar 18;131(10):3456-7
pubmed: 19275255
Biomaterials. 2020 May;239:119833
pubmed: 32062479
Nanoscale. 2017 Jan 05;9(2):706-718
pubmed: 27959374
Bioact Mater. 2019 Feb 21;4:132-141
pubmed: 30873505
Biomaterials. 2010 Nov;31(32):8181-7
pubmed: 20692699
Biomaterials. 2019 Aug;212:98-114
pubmed: 31112825
Bone. 2018 May;110:38-46
pubmed: 29355746
Adv Mater. 2012 Apr 24;24(16):2176-85
pubmed: 22447724
Innovation (Camb). 2020 Oct 13;1(3):100052
pubmed: 34557717
Bone Joint Res. 2019 Nov 02;8(10):481-488
pubmed: 31728188
Biomaterials. 2018 Apr;162:154-169
pubmed: 29454274
Adv Drug Deliv Rev. 2012 Sep;64(12):1257-76
pubmed: 22626978
Biomacromolecules. 2014 Mar 10;15(3):830-6
pubmed: 24432806
J Mater Sci Mater Med. 2016 Jul;27(7):118
pubmed: 27259708
Biomaterials. 2015 Dec;71:35-47
pubmed: 26318815
J Control Release. 2016 Oct 28;240:349-363
pubmed: 26778695
Front Endocrinol (Lausanne). 2019 Jul 23;10:490
pubmed: 31428045
Annu Rev Immunol. 2001;19:683-765
pubmed: 11244051
Acta Biomater. 2019 Sep 15;96:568-581
pubmed: 31271882
Injury. 2007 Mar;38 Suppl 1:S33-7
pubmed: 17383484
Clin Podiatr Med Surg. 2009 Oct;26(4):589-605
pubmed: 19778690
Biomaterials. 1996 Jan;17(2):93-102
pubmed: 8624401
Injury. 2016 Nov;47(11):2399-2406
pubmed: 27809990
Immunobiology. 2015 May;220(5):545-54
pubmed: 25582402
ACS Nano. 2017 May 23;11(5):4494-4506
pubmed: 28414902
Acta Biomater. 2013 Feb;9(2):4948-55
pubmed: 23099303
RSC Adv. 2019 Aug 21;9(45):26252-26262
pubmed: 35531040
Biomaterials. 2020 Feb;230:119642
pubmed: 31787332
Biomaterials. 2006 Mar;27(9):1741-8
pubmed: 16221493
Innovation (Camb). 2020 Aug 10;1(2):100041
pubmed: 34557714
Mol Cell Endocrinol. 2006 Mar 27;248(1-2):87-93
pubmed: 16406260
Nat Rev Immunol. 2019 Oct;19(10):626-642
pubmed: 31186549
Biomaterials. 2007 Nov;28(32):4845-69
pubmed: 17686513