Neurophysiological and ultrasonographic comparative study of autonomous nervous system in patients suffering from fibromyalgia and generalized anxiety disorder.
Cross-sectional area
Fibromyalgia
Generalized anxiety disorder
Sympathetic skin response
Vagus nerve
Journal
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
ISSN: 1590-3478
Titre abrégé: Neurol Sci
Pays: Italy
ID NLM: 100959175
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
01
06
2021
accepted:
16
09
2021
pubmed:
25
9
2021
medline:
16
3
2022
entrez:
24
9
2021
Statut:
ppublish
Résumé
Fibromyalgia (FM) and generalized anxiety disorder (GAD) share common clinical features: they both affect women more than men, their diagnosis is based solely on clinical criteria, and some of the symptoms such as anxiety, aches and muscle tension, sleep disorders, and cognitive dysfunction occur in both diseases. For both conditions, an underlying dysregulation of the autonomic nervous system (ANS) has been proposed. The aims of this study were to investigate ANS dysfunction in FM and GAD and compare them with controls. Sympathetic skin response (SSR) from palm and sole and cross-sectional area (CSA) of bilateral vagus nerves (VN) were measured in 28 healthy controls, 21 FM patients, and 24 GAD patients. CSA of VN was significantly smaller in FM patients (right: 1.97 ± 0.74mm This study confirms similar ANS abnormalities in FM and GAD that fairly distinguish them from controls and support the hypothesis of a common pathophysiological substrate underlying both conditions.
Sections du résumé
BACKGROUND
BACKGROUND
Fibromyalgia (FM) and generalized anxiety disorder (GAD) share common clinical features: they both affect women more than men, their diagnosis is based solely on clinical criteria, and some of the symptoms such as anxiety, aches and muscle tension, sleep disorders, and cognitive dysfunction occur in both diseases. For both conditions, an underlying dysregulation of the autonomic nervous system (ANS) has been proposed.
OBJECTIVE
OBJECTIVE
The aims of this study were to investigate ANS dysfunction in FM and GAD and compare them with controls.
METHODS
METHODS
Sympathetic skin response (SSR) from palm and sole and cross-sectional area (CSA) of bilateral vagus nerves (VN) were measured in 28 healthy controls, 21 FM patients, and 24 GAD patients.
RESULTS
RESULTS
CSA of VN was significantly smaller in FM patients (right: 1.97 ± 0.74mm
CONCLUSION
CONCLUSIONS
This study confirms similar ANS abnormalities in FM and GAD that fairly distinguish them from controls and support the hypothesis of a common pathophysiological substrate underlying both conditions.
Identifiants
pubmed: 34557968
doi: 10.1007/s10072-021-05606-3
pii: 10.1007/s10072-021-05606-3
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2813-2821Informations de copyright
© 2021. Fondazione Società Italiana di Neurologia.
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