Fungal keratitis caused by Pseudallescheria boydii: clinical and mycological characteristics.
Antifungal
Fungal keratitis
Pseudallescheria boydii
Journal
Journal of ophthalmic inflammation and infection
ISSN: 1869-5760
Titre abrégé: J Ophthalmic Inflamm Infect
Pays: Germany
ID NLM: 101553216
Informations de publication
Date de publication:
24 Sep 2021
24 Sep 2021
Historique:
received:
22
06
2021
accepted:
28
07
2021
entrez:
24
9
2021
pubmed:
25
9
2021
medline:
25
9
2021
Statut:
epublish
Résumé
Pseudallescheria keratitis is rare but important type of fungal keratitis because of the inherently resistance of the organism to many existing antifungal agents. Slit-lamp and confocal microscopy were used for clinical examinations. Fungal isolates were identified based on morphological characteristics and DNA sequence of the internal transcribed spacer region (ITS). In vitro antifungal susceptibility testing for fungal isolates was performed according to the Clinical and Laboratory Standards Institute (CLSI, M38-A2). All patients had a history of ocular trauma. In clinical examination hypopion were seen in three patients. The main antifungal medications were topical voriconazole. After treatment the visual acuity of all patients improved in 2-3 weeks. All four patients of Pseudallescheria keratitis had similar clinical features. Accurate and rapid identification of species should be helpful in treating p. boydii keratitis.
Sections du résumé
BACKGROUND
BACKGROUND
Pseudallescheria keratitis is rare but important type of fungal keratitis because of the inherently resistance of the organism to many existing antifungal agents.
METHODS
METHODS
Slit-lamp and confocal microscopy were used for clinical examinations. Fungal isolates were identified based on morphological characteristics and DNA sequence of the internal transcribed spacer region (ITS). In vitro antifungal susceptibility testing for fungal isolates was performed according to the Clinical and Laboratory Standards Institute (CLSI, M38-A2).
RESULT
RESULTS
All patients had a history of ocular trauma. In clinical examination hypopion were seen in three patients. The main antifungal medications were topical voriconazole. After treatment the visual acuity of all patients improved in 2-3 weeks.
CONCLUSION
CONCLUSIONS
All four patients of Pseudallescheria keratitis had similar clinical features. Accurate and rapid identification of species should be helpful in treating p. boydii keratitis.
Identifiants
pubmed: 34557976
doi: 10.1186/s12348-021-00255-1
pii: 10.1186/s12348-021-00255-1
pmc: PMC8460684
doi:
Types de publication
Journal Article
Langues
eng
Pagination
30Subventions
Organisme : tehran university of medical sciences and health services
ID : 99-1-99-46389
Informations de copyright
© 2021. The Author(s).
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