Disruptions in white matter microstructure associated with impaired visual associative memory in schizophrenia-spectrum illness.
Hippocampus
Memory
Schizophrenia
Tractography
Visuospatial associative memory
White matter
Journal
European archives of psychiatry and clinical neuroscience
ISSN: 1433-8491
Titre abrégé: Eur Arch Psychiatry Clin Neurosci
Pays: Germany
ID NLM: 9103030
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
received:
31
03
2021
accepted:
09
09
2021
pubmed:
25
9
2021
medline:
23
8
2022
entrez:
24
9
2021
Statut:
ppublish
Résumé
Episodic memory ability relies on hippocampal-prefrontal connectivity. However, few studies have examined relationships between memory performance and white matter (WM) microstructure in hippocampal-prefrontal pathways in schizophrenia-spectrum disorder (SSDs). Here, we investigated these relationships in individuals with first-episode psychosis (FEP) and chronic schizophrenia-spectrum disorders (SSDs) using tractography analysis designed to interrogate the microstructure of WM tracts in the hippocampal-prefrontal pathway. Measures of WM microstructure (fractional anisotropy [FA], radial diffusivity [RD], and axial diffusivity [AD]) were obtained for 47 individuals with chronic SSDs, 28 FEP individuals, 52 older healthy controls, and 27 younger healthy controls. Tractography analysis was performed between the hippocampus and three targets involved in hippocampal-prefrontal connectivity (thalamus, amygdala, nucleus accumbens). Measures of WM microstructure were then examined in relation to episodic memory performance separately across each group. Both those with FEP and chronic SSDs demonstrated impaired episodic memory performance. However, abnormal WM microstructure was only observed in individuals with chronic SSDs. Abnormal WM microstructure in the hippocampal-thalamic pathway in the right hemisphere was associated with poorer memory performance in individuals with chronic SSDs. These findings suggest that disruptions in WM microstructure in the hippocampal-prefrontal pathway may contribute to memory impairments in individuals with chronic SSDs but not FEP.
Identifiants
pubmed: 34557990
doi: 10.1007/s00406-021-01333-0
pii: 10.1007/s00406-021-01333-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
971-983Subventions
Organisme : National Health and Medical Research Council
ID : 1105825
Organisme : National Health and Medical Research Council
ID : 1150083
Organisme : National Health and Medical Research Council
ID : 1177370
Organisme : Brain and Behavior Research Foundation
ID : 21660
Informations de copyright
© 2021. Springer-Verlag GmbH Germany, part of Springer Nature.
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