Long-term wheel-running prevents reduction of grip strength in type 2 diabetic rats.
OLETF rat
grip strength
type 2 diabetes mellitus
wheel-running exercise
Journal
Physiological reports
ISSN: 2051-817X
Titre abrégé: Physiol Rep
Pays: United States
ID NLM: 101607800
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
revised:
27
08
2021
received:
29
06
2021
accepted:
31
08
2021
entrez:
24
9
2021
pubmed:
25
9
2021
medline:
1
3
2022
Statut:
ppublish
Résumé
Diabetic skeletal muscles show reduced contractile force and increased fatigability. Hands are a target for several diabetes-induced complications. Therefore, reduced handgrip strength often occurs as a consequence of diabetes. The aim of this study was to examine whether long-term exercise can prevent reduction of grip strength in type 2 diabetes mellitus (T2DM) model OLETF rats, and to explore the mechanisms underlying diabetes-induced grip strength reduction. Ten 5-week-old OLETF rats were used as experimental animals, and five non-diabetic LETO rats as controls of OLETF rats. Half OLETF rats performed daily voluntary wheel-running for 17 months (OLETF + EXE), and the rest of OLETF and LETO rats were sedentary. Grip strength was higher in OLETF + EXE and LETO groups than in OLETF group. OLETF group with hyperglycemia showed an increase in HbA1c, serum TNF-α, and muscle SERCA activity, but a decrease in circulating insulin. Each fiber area, total fiber area, and % total fiber area in type IIb fibers of extensor digitorum longus muscles were larger in OLETF + EXE and LETO groups than in OLETF group. There was a positive correlation between grip strength and the above three parameters concerning type IIb fiber area. Therefore, type IIb fiber atrophy may be the major direct cause of grip strength reduction in OLETF group, although there seems multiple etiological mechanisms. Long-term wheel-running may have blocked the diabetes-induced reduction of grip strength by preventing type IIb fiber atrophy. Regular exercise may be a potent modality for preventing not only the progression of diabetes but muscle dysfunction in T2DM patients.
Identifiants
pubmed: 34558206
doi: 10.14814/phy2.15046
pmc: PMC8461031
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e15046Informations de copyright
© 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.
Références
Cell. 2004 Oct 15;119(2):285-98
pubmed: 15479644
FASEB J. 2001 Nov;15(13):2415-22
pubmed: 11689466
J Biol Chem. 1995 May 19;270(20):12109-16
pubmed: 7744859
J Physiol. 1983 May;338:277-94
pubmed: 6348255
Br J Pharmacol. 1995 Sep;116(1):1680-4
pubmed: 8564237
J Gerontol A Biol Sci Med Sci. 2002 May;57(5):M326-32
pubmed: 11983728
Annu Rev Biochem. 2006;75:19-37
pubmed: 16756483
J Rheumatol. 2009 Dec;36(12):2766-71
pubmed: 19884270
Diabetes Care. 2009 Nov;32(11):1993-7
pubmed: 19549734
Diabetes Res Clin Pract. 1997 Feb;35(1):11-9
pubmed: 9113470
J Pathol. 2016 Feb;238(3):470-82
pubmed: 26586640
Neurochem Res. 2011 Feb;36(2):281-7
pubmed: 21076867
Gen Physiol Biophys. 1992 Jun;11(3):301-7
pubmed: 1426977
Biochem Biophys Res Commun. 1982 Oct 29;108(4):1418-23
pubmed: 7181900
J Physiol. 2003 Mar 1;547(Pt 2):395-403
pubmed: 12562893
Muscle Nerve. 2016 Sep;54(3):460-8
pubmed: 26833551
J Appl Physiol (1985). 2005 Sep;99(3):1193-204
pubmed: 16103522
Diabetes. 1989 Sep;38(9):1117-22
pubmed: 2670642
J Physiol. 2001 Nov 1;536(Pt 3):657-65
pubmed: 11691862
J Musculoskelet Neuronal Interact. 2017 Mar 1;17(1):433-443
pubmed: 28250247
Anal Biochem. 1976 May 7;72:248-54
pubmed: 942051
Anat Rec. 1998 Jun;251(2):240-4
pubmed: 9624455
Cell Calcium. 2005 Sep-Oct;38(3-4):291-302
pubmed: 16105684
Am J Physiol. 1993 May;264(5 Pt 1):C1308-15
pubmed: 8388635
Br J Nutr. 2017 Jan;117(1):21-29
pubmed: 28093090
J Appl Physiol (1985). 1998 May;84(5):1716-22
pubmed: 9572822
Chin Med J (Engl). 1999 Nov;112(11):1028-31
pubmed: 11721466
Brain. 2009 Oct;132(Pt 10):2724-33
pubmed: 19696031
Int J Biochem. 1993 Jun;25(6):941-6
pubmed: 8344450
Pflugers Arch. 1980 Mar;384(2):123-9
pubmed: 7189875
DNA Cell Biol. 2013 Jul;32(7):378-85
pubmed: 23815341
Diabetologia. 1997 Sep;40(9):1062-9
pubmed: 9300243
Q J Exp Physiol. 1989 Jan;74(1):65-74
pubmed: 2524084
Endocrinology. 2004 Nov;145(11):4806-12
pubmed: 15284206
Muscle Nerve. 1998 Dec;21(12):1647-54
pubmed: 9843064
Diabetes Res Clin Pract. 2018 Apr;138:271-281
pubmed: 29496507
Diabetes Care. 2009 Aug;32(8):1521-4
pubmed: 19509013
Diabetes. 1994 May;43(5):622-8
pubmed: 8168636
PLoS Med. 2014 Jan;11(1):e1001587
pubmed: 24453948
Am J Physiol. 1995 Nov;269(5 Pt 2):R1154-62
pubmed: 7503305
Am J Physiol. 1980 Jul;239(1):E88-95
pubmed: 6156604
J Physiol. 2014 Feb 1;592(3):523-35
pubmed: 24297852
Am J Physiol. 1982 Dec;243(6):H941-7
pubmed: 6216817
Horm Res. 2009 Nov;72 Suppl 1:36-41
pubmed: 19940494
Diabetes. 2006 Mar;55(3):760-7
pubmed: 16505240
N Engl J Med. 1986 Feb 13;314(7):403-8
pubmed: 3945267
Am J Physiol. 1980 Jun;238(6):E564-72
pubmed: 6155787
Diabetes. 1992 Nov;41(11):1422-8
pubmed: 1397718
Am J Physiol Endocrinol Metab. 2014 Mar;306(6):E592-605
pubmed: 24425761
J Appl Physiol (1985). 1995 Feb;78(2):629-37
pubmed: 7759433
Metabolism. 1993 Aug;42(8):971-7
pubmed: 8345821
Gene. 1997 Sep 15;197(1-2):169-75
pubmed: 9332364
Am J Physiol. 1998 Jul;275(1):E118-23
pubmed: 9688882
J Appl Physiol (1985). 2005 Aug;99(2):472-8
pubmed: 15831797
FASEB J. 2005 Apr;19(6):668-70
pubmed: 15665035
Nutr Metab Cardiovasc Dis. 2010 Oct;20(8):608-17
pubmed: 19695853
Eur J Appl Physiol. 2011 Jul;111(7):1545-52
pubmed: 21188413
Growth Horm IGF Res. 2017 Oct;36:57-59
pubmed: 28961553
J Gerontol A Biol Sci Med Sci. 2007 Nov;62(11):1204-10
pubmed: 18000139
Biochemistry. 1972 Jul 4;11(14):2627-33
pubmed: 4261555
Am J Physiol. 1992 Aug;263(2 Pt 1):E310-6
pubmed: 1514612
Calcif Tissue Int. 2015 Dec;97(6):602-10
pubmed: 26340892
J Am Med Dir Assoc. 2013 Aug;14(8):585-92
pubmed: 23537893
FASEB J. 2000 May;14(7):982-90
pubmed: 10783153
J Appl Physiol (1985). 1999 Sep;87(3):1075-82
pubmed: 10484579
J Appl Physiol (1985). 2010 Oct;109(4):1203-10
pubmed: 20634354
Exp Gerontol. 2008 Apr;43(4):317-29
pubmed: 18313875
J Hand Surg Am. 1995 Jan;20(1):109-14
pubmed: 7722249
Pflugers Arch. 2000 Apr;439(6):845-52
pubmed: 10784361
Scand J Med Sci Sports. 2014 Dec;24(6):e423-435
pubmed: 24814689
Am J Physiol. 1986 Nov;251(5 Pt 1):E515-23
pubmed: 2430466
N Engl J Med. 2002 Feb 7;346(6):393-403
pubmed: 11832527
Endocrinology. 2005 Apr;146(4):1789-97
pubmed: 15661854
J Psychosom Res. 2010 Jul;69(1):33-41
pubmed: 20630261
J Histochem Cytochem. 1957 Jul;5(4):420-36
pubmed: 13463314
Ann Phys Rehabil Med. 2018 Mar;61(2):99-104
pubmed: 29366905
Biomaterials. 2009 Mar;30(9):1689-96
pubmed: 19157537
Diabetes. 1996 Apr;45(4):440-5
pubmed: 8603765
Acta Physiol Scand. 2004 Jan;180(1):79-87
pubmed: 14706116