Transcriptomic Cross-Species Analysis of Chronic Liver Disease Reveals Consistent Regulation Between Humans and Mice.
Journal
Hepatology communications
ISSN: 2471-254X
Titre abrégé: Hepatol Commun
Pays: United States
ID NLM: 101695860
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
07
07
2021
received:
03
05
2021
accepted:
09
07
2021
pubmed:
25
9
2021
medline:
5
3
2022
entrez:
24
9
2021
Statut:
ppublish
Résumé
Mouse models are frequently used to study chronic liver diseases (CLDs). To assess their translational relevance, we quantified the similarity of commonly used mouse models to human CLDs based on transcriptome data. Gene-expression data from 372 patients were compared with data from acute and chronic mouse models consisting of 227 mice, and additionally to nine published gene sets of chronic mouse models. Genes consistently altered in humans and mice were mapped to liver cell types based on single-cell RNA-sequencing data and validated by immunostaining. Considering the top differentially expressed genes, the similarity between humans and mice varied among the mouse models and depended on the period of damage induction. The highest recall (0.4) and precision (0.33) were observed for the model with 12-months damage induction by CCl
Identifiants
pubmed: 34558834
doi: 10.1002/hep4.1797
pmc: PMC8710791
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
161-177Subventions
Organisme : LiSyM
ID : 031L0045
Organisme : LiSyM
ID : 031L0049
Organisme : LiSyM
ID : 031L0052
Organisme : TransQST
ID : 116030
Organisme : EU-ToxRisk
ID : 681002
Informations de copyright
© 2021 The Authors. Hepatology Communications published by Wiley Periodicals LLC on behalf of American Association for the Study of Liver Diseases.
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