Alisol A Inhibited the Proliferation, Migration, and Invasion of Nasopharyngeal Carcinoma Cells by Inhibiting the Hippo Signaling Pathway.
Alisol A
Hippo signaling pathway
nasopharyngeal carcinoma
Journal
Yonsei medical journal
ISSN: 1976-2437
Titre abrégé: Yonsei Med J
Pays: Korea (South)
ID NLM: 0414003
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
18
03
2021
revised:
07
07
2021
accepted:
13
07
2021
entrez:
24
9
2021
pubmed:
25
9
2021
medline:
28
9
2021
Statut:
ppublish
Résumé
Alisol A is a bioactive triterpenoid isolated from the Rhizoma Alismatis. Previous studies have shown that alisol A has anticancer potential. In this study, we explored the effect of alisol A on the growth of nasopharyngeal carcinoma (NPC) cells. MTT assay, colony formation assay, flow cytometry, transwell assay, wound healing assay, and western blotting were used to assess cell viability, proliferation, cell cycle, migration, invasion, and protein expression, respectively, in vitro. AutoDock Vina and Discovery Studio software were used for molecular docking. Alisol A inhibited the viability, proliferation, migration, and invasion of NPC cells. The molecular docking simulation assay confirmed that alisol A bound to YAP protein. In addition, alisol A promoted the phosphorylation of YAP and suppressed the expression of YAP in NPC cells. Alisol A inhibited the proliferation, migration, and invasion of NPC cells by inhibiting the Hippo signaling pathway. Alisol A may be a candidate drug for NPC.
Identifiants
pubmed: 34558868
pii: 62.895
doi: 10.3349/ymj.2021.62.10.895
pmc: PMC8470560
doi:
Substances chimiques
Cholestenones
0
alisol A
19885-10-0
Protein Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
895-902Informations de copyright
© Copyright: Yonsei University College of Medicine 2021.
Déclaration de conflit d'intérêts
The authors have no potential conflicts of interest to disclose.
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