Telomere lengths in Barrett's esophagus as a precancerous lesion.
Barrett’s esophagus
Cardiac type
Intestinal type
Q-FISH
Telomere
Journal
Esophagus : official journal of the Japan Esophageal Society
ISSN: 1612-9067
Titre abrégé: Esophagus
Pays: Japan
ID NLM: 101206627
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
13
07
2021
accepted:
16
09
2021
pubmed:
25
9
2021
medline:
29
3
2022
entrez:
24
9
2021
Statut:
ppublish
Résumé
We have reported that precancerous conditions and lesions invariably have shorter telomeres and associated chromosomal instability relative to normal tissue. Using the Q-FISH method and our original software, Tissue Telo, we estimated telomere lengths in cardiac- and intestinal-type mucosae in 48 cases of Barrett's esophagus (short-segment (SS) n = 18; long-segment (LS) n = 30). There were no significant differences in telomere length between the cardiac and intestinal types in any of the 48 cases, suggesting that the presence or absence of goblet cells in the columnar segments is unrelated to telomere-dependent chromosomal instability in Barrett's esophagus. In LS Barrett's esophagus, telomeres were shorter in cardiac-type than in intestinal-type mucosa, suggesting that the former may play a more important role than the latter as a precancerous lesion in LS. Telomeres in cardiac-type mucosa were longer in SS than in LS, supporting the possibility that cardiac-type LS may pose a higher risk as a precancerous lesion than cardiac-type SS. Although it has been considered that Barrett's carcinoma arises only from intestinal-type mucosa, our present findings support previous histogenetic studies suggesting that cardiac-type mucosa is more important as a precancerous condition in Barrett's esophagus than anticipated.
Sections du résumé
BACKGROUND
We have reported that precancerous conditions and lesions invariably have shorter telomeres and associated chromosomal instability relative to normal tissue.
METHODS
Using the Q-FISH method and our original software, Tissue Telo, we estimated telomere lengths in cardiac- and intestinal-type mucosae in 48 cases of Barrett's esophagus (short-segment (SS) n = 18; long-segment (LS) n = 30).
RESULTS
There were no significant differences in telomere length between the cardiac and intestinal types in any of the 48 cases, suggesting that the presence or absence of goblet cells in the columnar segments is unrelated to telomere-dependent chromosomal instability in Barrett's esophagus. In LS Barrett's esophagus, telomeres were shorter in cardiac-type than in intestinal-type mucosa, suggesting that the former may play a more important role than the latter as a precancerous lesion in LS. Telomeres in cardiac-type mucosa were longer in SS than in LS, supporting the possibility that cardiac-type LS may pose a higher risk as a precancerous lesion than cardiac-type SS.
CONCLUSIONS
Although it has been considered that Barrett's carcinoma arises only from intestinal-type mucosa, our present findings support previous histogenetic studies suggesting that cardiac-type mucosa is more important as a precancerous condition in Barrett's esophagus than anticipated.
Identifiants
pubmed: 34559348
doi: 10.1007/s10388-021-00884-4
pii: 10.1007/s10388-021-00884-4
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
287-293Informations de copyright
© 2021. The Japan Esophageal Society.
Références
Blackburn EH. Switching and signaling at the telomere. Cell. 2001;106:661–73.
doi: 10.1016/S0092-8674(01)00492-5
de Lange TS. The protein complex that shapes and safeguards human telomeres. Genes Dev. 2005;19:2100–10.
doi: 10.1101/gad.1346005
DePinho RA. The age of cancer. Nature. 2000;408:248–54.
doi: 10.1038/35041694
Londono-Vallejo JA. Telomere instability and cancer. Biochimie. 2008;90:73–82.
doi: 10.1016/j.biochi.2007.07.009
Ikeda H, Aida J, Hatamochi A, et al. Quantitative fluorescence in situ hybridization measurement of telomere length in skin with/without sun exposure or actinic keratosis. Hum Pathol. 2014;45:473–80.
doi: 10.1016/j.humpath.2013.10.009
Aida J, Kobayashi T, Saku T, et al. Short telomeres in an oral precancerous lesion: Q-FISH analysis of leukoplakia. J Oral Pathol Med. 2012;41:372–8.
doi: 10.1111/j.1600-0714.2011.01120.x
Shiraishi H, Mikami T, Aida J, et al. Telomere shortening in Barrett’s mucosa and esophageal adenocarcinoma and its association with loss of heterozygosity. Scand J Gastroenterol. 2009;44:538–44.
doi: 10.1080/00365520902718705
Izumiyama-Shimomura N, Nakamura K, Aida J, et al. Short telomeres and chromosome instability prior to histologic malignant progression and cytogenetic aneuploidy in papillary urothelial neoplasms. Urol Oncol. 2014;32:135–45.
doi: 10.1016/j.urolonc.2012.12.005
Aida J, Izumo T, Shimomura N, et al. Telomere lengths in the oral epithelia with and without carcinoma. Eur J Cancer. 2010;46:430–8.
doi: 10.1016/j.ejca.2009.10.018
Takubo K, Fujita M, Izumiyama N, et al. Q-FISH analysis of telomere and chromosome instability in the oesophagus with and without squamous cell carcinoma in situ. J Pathol. 2010;221:201–9.
doi: 10.1002/path.2704
Aida J, Yokoyama A, Izumiyama N, et al. Alcoholics show reduced telomere length in the oesophagus. J Pathol. 2011;223:410–6.
doi: 10.1002/path.2817
Aida J, Yokoyama A, Shimomura N, et al. Telomere shortening in the esophagus of Japanese alcoholics: relationships with chromoendoscopic findings, ALDH2 and ADH1B genotypes and smoking history. PLoS ONE. 2013;8:e63860.
doi: 10.1371/journal.pone.0063860
Matsuda Y, Ishiwata T, Izumiyama-Shimomura N, et al. Gradual telomere shortening and increasing chromosomal instability among PanIN grades and normal ductal epithelia with and without cancer in the pancreas. PLoS ONE. 2015;10:e0117575.
doi: 10.1371/journal.pone.0117575
Aoki Y, Aida J, Kawano Y, et al. Telomere length of gallbladder epithelium is shortened in patients with congenital biliary dilatation: measurement by quantitative fluorescence in situ hybridization. J Gastroenterol. 2018;53:291–301.
doi: 10.1007/s00535-017-1411-5
O’Sullivan JN, Bronner MP, Brentnall TA, et al. Chromosomal instability in ulcerative colitis is related to telomere shortening. Nat Genet. 2002;32:280–4.
doi: 10.1038/ng989
Meeker AK, Hicks JL, Iacobuzio-Donahue CA, et al. Telomere length abnormalities occur early in the initiation of epithelial carcinogenesis. Clin Cancer Res. 2004;10:3317–26.
doi: 10.1158/1078-0432.CCR-0984-03
Kim H, Oh BK, Roncalli M, et al. Large liver cell change in hepatitis B virus-related liver cirrhosis. Hepatology (Baltimore, MD). 2009;50:752–62.
doi: 10.1002/hep.23072
Spechler SJ, Goyal RK. The columnar-lined esophagus, intestinal metaplasia, and norman barrett. Gastroenterology. 1996;110:614–21.
doi: 10.1053/gast.1996.v110.agast960614
Ruol A, Parenti A, Zaninotto G, et al. Intestinal metaplasia is the probable common precursor of adenocarcinoma in barrett esophagus and adenocarcinoma of the gastric cardia. Cancer. 2000;88:2520–8.
doi: 10.1002/1097-0142(20000601)88:11<2520::AID-CNCR13>3.0.CO;2-L
Takubo K, Aida J, Naomoto Y, et al. Cardiac rather than intestinal-type background in endoscopic resection specimens of minute Barrett adenocarcinoma. Hum Pathol. 2009;40:65–74.
doi: 10.1016/j.humpath.2008.06.008
Aida J, Vieth M, Shepherd NA, et al. Is Carcinoma in columnar-lined esophagus always located adjacent to intestinal metaplasia?: A histopathologic assessment. Am J Surg Pathol. 2015;39:188–96.
doi: 10.1097/PAS.0000000000000350
Coleman HG, Bhat SK, Murray LJ, et al. Symptoms and endoscopic features at barrett’s esophagus diagnosis: implications for neoplastic progression risk. Am J Gastroenterol. 2014;109:527–34.
doi: 10.1038/ajg.2014.10
Aida J, Izumiyama-Shimomura N, Nakamura K, et al. Telomere length variations in 6 mucosal cell types of gastric tissue observed using a novel quantitative fluorescence in situ hybridization method. Hum Pathol. 2007;38:1192–200.
doi: 10.1016/j.humpath.2006.11.023
Kurabayashi R, Takubo K, Aida J, et al. Luminal and cancer cells in the breast show more rapid telomere shortening than myoepithelial cells and fibroblasts. Hum Pathol. 2008;39:1647–55.
doi: 10.1016/j.humpath.2008.04.005
Aida J, Izumiyama-Shimomura N, Nakamura K, et al. Basal cells have longest telomeres measured by tissue Q-FISH method in lingual epithelium. Exp Gerontol. 2008;43:833–9.
doi: 10.1016/j.exger.2008.06.001
O’Sullivan JN, Finley JC, Risques RA, et al. Telomere length assessment in tissue sections by quantitative FISH: image analysis algorithms. Cytometry A. 2004;58:120–31.
doi: 10.1002/cyto.a.20006
Ohashi M, Aizawa S, Ooka H, et al. A new human diploid cell strain, TIG-1, for the research on cellular aging. Expl Gerontol. 1980;15:121–33.
doi: 10.1016/0531-5565(80)90083-2
Takubo K, Aida J, Izumiyama N, et al. Chromosomal instability and telomere lengths of each chromosomal arm measured by Q-FISH in human fibroblast strains prior to replicative senescence. Mech Ageing Dev. 2010;131:614–24.
doi: 10.1016/j.mad.2010.08.007