Virtual Biopsy by Electrical Impedance Spectroscopy in Barrett's Carcinoma.
Barrett’s cancer
Electrical impedance spectroscopy
Esophageal carcinoma
Virtual biopsy
Journal
Journal of gastrointestinal cancer
ISSN: 1941-6636
Titre abrégé: J Gastrointest Cancer
Pays: United States
ID NLM: 101479627
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
accepted:
19
08
2021
pubmed:
25
9
2021
medline:
5
11
2022
entrez:
24
9
2021
Statut:
ppublish
Résumé
Early detection of adenocarcinomas in the esophagus is crucial for achieving curative endoscopic therapy. Targeted biopsies of suspicious lesions, as well as four-quadrant biopsies, represent the current diagnostic standard. However, this procedure is time-consuming, cost-intensive, and examiner-dependent. The aim of this study was to test whether impedance spectroscopy is capable of distinguishing between healthy, premalignant, and malignant lesions. An ex vivo measurement method was developed to examine esophageal lesions using impedance spectroscopy immediately after endoscopic resection. After endoscopic resection of suspicious lesions in the esophagus, impedance measurements were performed on resected cork-covered tissue using a measuring head that was developed, with eight gold electrodes, over 10 different measurement settings and with frequencies from 100 Hz to 1 MHz. A total of 105 measurements were performed in 60 patients. A dataset of 400 per investigation and a total of more than 42,000 impedance measurements were therefore collected. Electrical impedance spectroscopy (EIS) was able to detect dysplastic esophageal mucosa with a sensitivity of 81% in Barrett's esophagus. In summary, EIS was able to distinguish different tissue characteristics in the different esophageal tissues. EIS thus holds potential for further development of targeted biopsies during surveillance endoscopy. Trial Registration NCT04046601.
Identifiants
pubmed: 34559362
doi: 10.1007/s12029-021-00703-0
pii: 10.1007/s12029-021-00703-0
pmc: PMC9630236
doi:
Banques de données
ClinicalTrials.gov
['NCT04046601']
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
948-957Informations de copyright
© 2021. The Author(s).
Références
Pech O, Behrens A, May A, et al. Long-term results and risk factor analysis for recurrence after curative endoscopic therapy in 349 patients with high-grade intraepithelial neoplasia and mucosal adenocarcinoma in Barrett’s oesophagus. Gut. 2008;57(9):1200–6. https://doi.org/10.1136/gut.2007.142539 .
doi: 10.1136/gut.2007.142539
pubmed: 18460553
Global Burden of Disease Cancer C, Fitzmaurice C, Abate D, et al. Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 29 cancer groups, 1990 to 2017: a systematic analysis for the global burden of disease study. JAMA Oncol. Sep 27 2019. https://doi.org/10.1001/jamaoncol.2019.2996 .
Bennett C, Vakil N, Bergman J, et al. Consensus statements for management of Barrett’s dysplasia and early-stage esophageal adenocarcinoma, based on a Delphi process. Gastroenterology. 2012;143(2):336–46. https://doi.org/10.1053/j.gastro.2012.04.032 .
doi: 10.1053/j.gastro.2012.04.032
pubmed: 22537613
American Gastroenterological A, Spechler SJ, Sharma P, Souza RF, Inadomi JM, Shaheen NJ. American Gastroenterological Association medical position statement on the management of Barrett’s esophagus. Gastroenterology. 2011;140(3):1084–91. https://doi.org/10.1053/j.gastro.2011.01.030 .
doi: 10.1053/j.gastro.2011.01.030
Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R, Global Consensus G. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol. Aug 2006;101(8):1900–20; quiz 1943. https://doi.org/10.1111/j.1572-0241.2006.00630.x .
Wani S, Williams JL, Komanduri S, Muthusamy VR, Shaheen NJ. Endoscopists systematically undersample patients with long-segment Barrett’s esophagus: an analysis of biopsy sampling practices from a quality improvement registry. Gastrointest Endosc. 11 2019;90(5):732–741.e3. https://doi.org/10.1016/j.gie.2019.04.250 .
Sharma P, Hawes RH, Bansal A, et al. Standard endoscopy with random biopsies versus narrow band imaging targeted biopsies in Barrett’s oesophagus: a prospective, international, randomised controlled trial. Gut. 2013;62(1):15–21. https://doi.org/10.1136/gutjnl-2011-300962 .
doi: 10.1136/gutjnl-2011-300962
pubmed: 22315471
Muto M, Minashi K, Yano T, et al. Early detection of superficial squamous cell carcinoma in the head and neck region and esophagus by narrow band imaging: a multicenter randomized controlled trial. J Clin Oncol. 2010;28(9):1566–72. https://doi.org/10.1200/JCO.2009.25.4680 .
doi: 10.1200/JCO.2009.25.4680
pubmed: 20177025
pmcid: 2849774
Wallace MB, Crook JE, Saunders M, et al. Multicenter, randomized, controlled trial of confocal laser endomicroscopy assessment of residual metaplasia after mucosal ablation or resection of GI neoplasia in Barrett’s esophagus. Gastrointest Endosc. Sep 2012;76(3):539–47 e1. https://doi.org/10.1016/j.gie.2012.05.004 .
Suselbeck T, Thielecke H, Weinschenk I, et al. In vivo intravascular electric impedance spectroscopy using a new catheter with integrated microelectrodes. Basic Res Cardiol. 2005;100(1):28–34. https://doi.org/10.1007/s00395-004-0501-8 .
doi: 10.1007/s00395-004-0501-8
pubmed: 15614589
Brown BH, Tidy JA, Boston K, Blackett AD, Smallwood RH, Sharp F. Relation between tissue structure and imposed electrical current flow in cervical neoplasia. Lancet. 2000;355(9207):892–5. https://doi.org/10.1016/S0140-6736(99)09095-9 .
doi: 10.1016/S0140-6736(99)09095-9
pubmed: 10752706
Farre R, Blondeau K, Clement D, et al. Evaluation of oesophageal mucosa integrity by the intraluminal impedance technique. Gut. 2011;60(7):885–92. https://doi.org/10.1136/gut.2010.233049 .
doi: 10.1136/gut.2010.233049
pubmed: 21303918
Gonzalez-Correa CA, Brown BH, Smallwood RH, Stephenson TJ, Stoddard CJ, Bardhan KD. Low frequency electrical bioimpedance for the detection of inflammation and dysplasia in Barrett’s oesophagus. Physiol Meas. 2003;24(2):291–6.
doi: 10.1088/0967-3334/24/2/305
pubmed: 12812415
Knabe M, Kurz C, Knoll T, et al. Diagnosing early Barrett’s neoplasia and oesophageal squamous cell neoplasia by bioimpedance spectroscopy in human tissue. United European Gastroenterol J. 2013;1(4):236–41. https://doi.org/10.1177/2050640613495198 .
doi: 10.1177/2050640613495198
pubmed: 24917967
pmcid: 4040794
R Core Team (2020). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL https://www.R-project.org/ . 2020.
Sharma P, Savides TJ, Canto MI, et al. The American Society for Gastrointestinal Endoscopy PIVI (Preservation and Incorporation of Valuable Endoscopic Innovations) on imaging in Barrett’s Esophagus. Gastrointest Endosc. 2012;76(2):252–4. https://doi.org/10.1016/j.gie.2012.05.007 .
doi: 10.1016/j.gie.2012.05.007
pubmed: 22817781
Halter RJ, Schned AR, Heaney JA, Hartov A. Passive bioelectrical properties for assessing high- and low-grade prostate adenocarcinoma. Prostate. 2011;71(16):1759–67. https://doi.org/10.1002/pros.21393 .
doi: 10.1002/pros.21393
pubmed: 21520155
Aberg P, Birgersson U, Elsner P, Mohr P, Ollmar S. Electrical impedance spectroscopy and the diagnostic accuracy for malignant melanoma. Exp Dermatol. 2011;20(8):648–52. https://doi.org/10.1111/j.1600-0625.2011.01285.x .
doi: 10.1111/j.1600-0625.2011.01285.x
pubmed: 21539620
Abdul S, Brown BH, Milnes P, Tidy JA. The use of electrical impedance spectroscopy in the detection of cervical intraepithelial neoplasia. Int J Gynecol Cancer Sep-Oct. 2006;16(5):1823–32. https://doi.org/10.1111/j.1525-1438.2006.00651.x .
doi: 10.1111/j.1525-1438.2006.00651.x
Sun TP, Ching CT, Cheng CS, et al. The use of bioimpedance in the detection/screening of tongue cancer. Cancer Epidemiol. 2010;34(2):207–11. https://doi.org/10.1016/j.canep.2009.12.017 .
doi: 10.1016/j.canep.2009.12.017
pubmed: 20097150
Gonzalez-Correa CA, Brown BH, Smallwood RH, et al. Assessing the conditions for in vivo electrical virtual biopsies in Barrett’s oesophagus. Med Biol Eng Comput. 2000;38(4):373–6.
doi: 10.1007/BF02345004
pubmed: 10984933
Murdoch C, Brown BH, Hearnden V, et al. Use of electrical impedance spectroscopy to detect malignant and potentially malignant oral lesions. Int J Nanomedicine. 2014;9:4521–32. https://doi.org/10.2147/IJN.S64087 .
doi: 10.2147/IJN.S64087
pubmed: 25285005
pmcid: 4181751
Malvehy J, Hauschild A, Curiel-Lewandrowski C, et al. Clinical performance of the Nevisense system in cutaneous melanoma detection: an international, multicentre, prospective and blinded clinical trial on efficacy and safety. Br J Dermatol. 2014;171(5):1099–107. https://doi.org/10.1111/bjd.13121 .
doi: 10.1111/bjd.13121
pubmed: 24841846
pmcid: 4257502
Tidy JA, Brown BH, Healey TJ, et al. Accuracy of detection of high-grade cervical intraepithelial neoplasia using electrical impedance spectroscopy with colposcopy. BJOG. Mar 2013;120(4):400–10; discussion 410–1. https://doi.org/10.1111/1471-0528.12096 .
Keshtkar A, Salehnia Z, Somi MH, Eftekharsadat AT. Some early results related to electrical impedance of normal and abnormal gastric tissue. Phys Med. 2012;28(1):19–24. https://doi.org/10.1016/j.ejmp.2011.01.002 .
doi: 10.1016/j.ejmp.2011.01.002
pubmed: 21334938
Keshtkar A, Salehnia Z, Keshtkar A, Shokouhi B. Bladder cancer detection using electrical impedance technique (tabriz mark 1). Patholog Res Int. 2012;2012: 470101. https://doi.org/10.1155/2012/470101 .
doi: 10.1155/2012/470101
pubmed: 22567538
pmcid: 3337498
Antakia R, Brown BH, Highfield PE, Stephenson TJ, Brown NJ, Balasubramanian SP. Electrical impedance spectroscopy to aid parathyroid identification and preservation in central compartment neck surgery: a proof of concept in a rabbit model. Surg Innov. 2016;23(2):176–82. https://doi.org/10.1177/1553350615607639 .
doi: 10.1177/1553350615607639
pubmed: 26423912