Differential barcoding of opioid receptors trafficking.
G protein-coupled receptors
motif
nociceptin receptor
opioid receptors
post-translational modification
trafficking
Journal
Journal of neuroscience research
ISSN: 1097-4547
Titre abrégé: J Neurosci Res
Pays: United States
ID NLM: 7600111
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
25
07
2021
received:
26
11
2020
accepted:
05
08
2021
pubmed:
25
9
2021
medline:
1
4
2022
entrez:
24
9
2021
Statut:
ppublish
Résumé
Over the past several years, studies have highlighted the δ-opioid receptor (DOPr) as a promising therapeutic target for chronic pain management. While exhibiting milder undesired effects than most currently prescribed opioids, its specific agonists elicit effective analgesic responses in numerous animal models of chronic pain, including inflammatory, neuropathic, diabetic, and cancer-related pain. However, as compared with the extensively studied μ-opioid receptor, the molecular mechanisms governing its trafficking remain elusive. Recent advances have denoted several significant particularities in the regulation of DOPr intracellular routing, setting it apart from the other members of the opioid receptor family. Although they share high homology, each opioid receptor subtype displays specific amino acid patterns potentially involved in the regulation of its trafficking. These precise motifs or "barcodes" are selectively recognized by regulatory proteins and therefore dictate several aspects of the itinerary of a receptor, including its anterograde transport, internalization, recycling, and degradation. With a specific focus on the regulation of DOPr trafficking, this review will discuss previously reported, as well as potential novel trafficking barcodes within the opioid and nociceptin/orphanin FQ opioid peptide receptors, and their impact in determining distinct interactomes and physiological responses.
Substances chimiques
Analgesics
0
Analgesics, Opioid
0
Opioid Peptides
0
Receptors, Opioid
0
Receptors, Opioid, mu
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
99-128Subventions
Organisme : CIHR
ID : PJT-162103
Pays : Canada
Informations de copyright
© 2021 Wiley Periodicals LLC.
Références
Abdallah, K., & Gendron, L. (2018). The delta opioid receptor in pain control. Handbook of Experimental Pharmacology, 247, 147-177.
Arvidsson, U., Dado, R. J., Riedl, M., Lee, J. H., Law, P. Y., Loh, H. H., Elde, R., & Wessendorf, M. W. (1995). δ-Opioid receptor immunoreactivity: Distribution in brainstem and spinal cord, and relationship to biogenic amines and enkephalin. Journal of Neuroscience, 15, 1215-1235.
Bannert, N., Craig, S., Farzan, M., Sogah, D., Santo, N. V., Choe, H., & Sodroski, J. (2001). Sialylated O-glycans and sulfated tyrosines in the NH2-terminal domain of CC chemokine receptor 5 contribute to high affinity binding of chemokines. Journal of Experimental Medicine, 194, 1661-1673.
Barak, L. S., Tiberi, M., Freedman, N. J., Kwatra, M. M., Lefkowitz, R. J., & Caron, M. G. (1994). A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated β2-adrenergic receptor sequestration. Journal of Biological Chemistry, 269, 2790-2795.
Bartlett, S. E., Enquist, J., Hopf, F. W., Lee, J. H., Gladher, F., Kharazia, V., Waldhoer, M., Mailliard, W. S., Armstrong, R., Bonci, A., & Whistler, J. L. (2005). Dopamine responsiveness is regulated by targeted sorting of D2 receptors. Proceedings of the National Academy of Sciences of the United States of America, 102, 11521-11526.
Bauch, C., Koliwer, J., Buck, F., Hönck, H. H., & Kreienkamp, H. J. (2014). Subcellular sorting of the G-protein coupled mouse somatostatin receptor 5 by a network of PDZ-domain containing proteins. PLoS ONE, 9, 1-10. https://doi.org/10.1371/journal.pone.0088529
Beaudette, K. N., Lew, J., & Wang, J. H. (1993). Substrate specificity characterization of a cdc2-like protein kinase purified from bovine brain. Journal of Biological Chemistry, 268, 20825-20830.
Beaudry, H., Mercier-Blais, A. A., Delaygue, C., Lavoie, C., Parent, J. L., Neugebauer, W., & Gendron, L. (2015). Regulation of μ and δ opioid receptor functions: Involvement of cyclin-dependent kinase 5. British Journal of Pharmacology, 172, 2573-2587.
Berg, D., Holzmann, C., & Riess, O. (2003). 14-3-3 Proteins in the nervous system. Nature Reviews Neuroscience, 4, 752-762.
Bermak, J. C., Li, M., Bullock, C., & Zhou, Q. Y. (2001). Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein. Nature Cell Biology, 3, 492-498.
Berman, D. M., Wilkie, T. M., & Gilman, A. G. (1996). GAIP and RGS4 are GTPase-activating proteins for the G(i) subfamily of G protein α subunits. Cell, 86, 445-452.
Berson, E. L., Rosner, B., Weigel-DiFranco, C., Dryja, T. P., & Sandberg, M. A. (2002). Disease progression in patients with dominant retinitis pigmentosa and rhodopsin mutations. Investigative Ophthalmology & Visual Science, 43, 3027-3036.
Bie, B., Zhu, W., & Pan, Z. Z. (2009). Rewarding morphine-induced synaptic function of δ-opioid receptors on central glutamate synapses. Journal of Pharmacology and Experimental Therapeutics, 329, 290-296.
Binda, C., Génier, S., Degrandmaison, J., Picard, S., Fréchette, L., Jean, S., Marsault, E., & Parent, J. L. (2019). L-type prostaglandin D synthase regulates the trafficking of the PGD2 DP1 receptor by interacting with the GTPase Rab4. Journal of Biological Chemistry, 294(45), 16865-16883.
Bonifacino, J. S., & Traub, L. M. (2003). Signals for sorting of transmembrane proteins to endosomes and lysosomes. Annual Review of Biochemistry, 72, 395-447.
Borsodi, A., Bruchas, M., Caló, G., Chavkin, C., Christie, M. J., Civelli, O., Connor, M., Cox, B. M., Devi, L. A., Evans, C., & Höllt, V. (2019). Opioid receptors (version 2019.4) in the IUPHAR/BPS guide to pharmacology database. IUPHAR/BPS Guide to Pharmacology CITE, 2019(4). Retrieved from https://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=50
Bouley, R., Sun, T. X., Chenard, M., McLaughlin, M., McKee, M., Lin, H. Y., Brown, D., & Ausiello, D. A. (2003). Functional role of the NPxxY motif in internalization of the type 2 vasopressin receptor in LLC-PK1 cells. American Journal of Physiology-Cell Physiology, 285, 750-762.
Brainin-Mattos, J., Smith, N. D., Malkmus, S., Rew, Y., Goodman, M., Taulane, J., & Yaksh, T. L. (2006). Cancer-related bone pain is attenuated by a systemically available δ-opioid receptor agonist. Pain, 122, 174-181. https://doi.org/10.1016/j.pain.2006.01.032
Cahill, C. M., McClellan, K. A., Morinville, A., Hoffert, C., Hubatsch, D., O'Donnell, D., & Beaudet, A. (2001). Immunohistochemical distribution of delta opioid receptors in the rat central nervous system: Evidence for somatodendritic labeling and antigen-specific cellular compartmentalization. Journal of Comparative Neurology, 440, 65-84.
Cahill, C. M., Morinville, A., Hoffert, C., O’Donnell, D., & Beaudet, A. (2003). Up-regulation and trafficking of δ opioid receptor in a model of chronic inflammation: Implications for pain control. Pain, 101, 199-208.
Cahill, C. M., Morinville, A., Lee, M. C., Vincent, J. P., Collier, B., & Beaudet, A. (2001). Prolonged morphine treatment targets delta opioid receptors to neuronal plasma membranes and enhances delta-mediated antinociception. Journal of Neuroscience, 21, 7598-7607.
Cao, T. T., Deacon, H. W., Reczek, D., Bretscher, A., & Von Zastrow, M. (1999). A kinase-regulated PDZ-domain interaction controls endocytic sorting of the β2-adrenergic receptor. Nature, 401, 286-290. https://doi.org/10.1038/45816
Carlezon, W. A., Beguin, C., DiNieri, J. A., Baumann, M. H., Richards, M. R., Todtenkopf, M. S., Rothman, R. B., Ma, Z., Lee, D. Y., & Cohen, B. M. (2006). Depressive-like effects of the κ-opioid receptor agonist salvinorin A on behavior and neurochemistry in rats. Journal of Pharmacology and Experimental Therapeutics, 316, 440-447.
Cen, B., Xiong, Y., Ma, L., & Pie, G. (2001). Direct and differential interaction of β-arrestins with the intracellular domains of different opioid receptors. Molecular Pharmacology, 59, 758-764.
Cen, B., Yu, Q., Guo, J., Wu, Y., Ling, K., Cheng, Z., Ma, L., & Pei, G. (2001). Direct binding of beta-arrestins to two distinct intracellular domains of the delta opioid receptor. Journal of Neurochemistry, 76, 1887-1894.
Chakrabarti, S., Chang, A., Liu, N.-J., & Gintzler, A. R. (2016). Chronic opioid treatment augments caveolin-1 scaffolding: Relevance to stimulatory μ-opioid receptor adenylyl cyclase signaling. Journal of Neurochemistry, 139, 737-747.
Charfi, I., Abdallah, K., Gendron, L., & Pineyro, G. (2017). Delta opioid receptors recycle to the membrane after sorting to the degradation path. Cellular and Molecular Life Sciences, 1, 1-15.
Chaturvedi, K., Bandari, P., Chinen, N., & Howells, R. D. (2001). Proteasome involvement in agonist-induced down-regulation of μ and δ opioid receptors. Journal of Biological Chemistry, 276, 12345-12355.
Chen, C., Li, J. G., Chen, Y., Huang, P., Wang, Y., & Liu-Chen, L. Y. (2006). GEC1 interacts with the κ opioid receptor and enhances expression of the receptor. Journal of Biological Chemistry, 281, 7983-7993.
Chen, C., Shahabi, V., Xu, W., & Liu-Chen, L. Y. (1998). Palmitoylation of the rat μ opioid receptor. FEBS Letters, 441, 148-152.
Chen, Y., Chen, C., Kotsikorou, E., Lynch, D. L., Reggio, P. H., & Liu-Chen, L. Y. (2009). GEC1-κ opioid receptor binding involves hydrophobic interactions: GEC1 has chaperone-like effect. Journal of Biological Chemistry, 284, 1673-1685.
Chieng, B., & Christie, M. J. (2009). Chronic morphine treatment induces functional delta-opioid receptors in amygdala neurons that project to periaqueductal grey. Neuropharmacology, 57, 430-437. https://doi.org/10.1016/j.neuropharm.2009.06.034
Chua, C. E. L., & Tang, B. L. (2018). Rab 10-a traffic controller in multiple cellular pathways and locations. Journal of Cellular Physiology, 233(9), 6483-6494. https://doi.org/10.1002/jcp.26503
Codd, E. E., Carson, J. R., Colburn, R. W., Stone, D. J., Van Besien, C. R., Zhang, S. P., Wade, P. R., Gallantine, E. L., Meert, T. F., Molino, L., & Pullan, S. (2009). JNJ-20788560 [9-(8-azabicyclo[3.2.1]oct-3-ylidene)-9H-xanthene-3-carboxylic acid diethylamide], a selective delta opioid receptor agonist, is a potent and efficacious antihyperalgesic agent that does not produce respiratory depression, pharmacologic tolerance, or physical dependence. Journal of Pharmacology and Experimental Therapeutics, 329, 241-251.
Coleman, J. L. J., Ngo, T., & Smith, N. J. (2017). The G protein-coupled receptor N-terminus and receptor signalling: N-tering a new era. Cellular Signalling, 33, 1-9.
Concepcion, F., & Chen, J. (2010). Q344ter mutation causes mislocalization of rhodopsin molecules that are catalytically active: A mouse model of Q344ter-induced retinal degeneration. PLoS ONE, 5(6), e10904.
Costa, T., & Herz, A. (1989). Antagonists with negative intrinsic activity at δ opioid receptors coupled to GTP-binding proteins. Proceedings of the National Academy of Sciences of the United States of America, 86, 7321-7325.
Couet, J., Li, S., Okamoto, T., Ikezu, T., & Lisanti, M. P. (1997). Identification of peptide and protein ligands for the caveolin- scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins. Journal of Biological Chemistry, 272, 6525-6533.
Cvejic, S., Trapaidze, N., Cyr, C., & Devi, L. A. (1996). Thr353, located within the COOH-terminal tail of the δ opiate receptor, is involved in receptor down-regulation. Journal of Biological Chemistry, 271, 4073-4076.
Daga, P. R., & Zaveri, N. T. (2012). Homology modeling and molecular dynamics simulations of the active state of the nociceptin receptor reveal new insights into agonist binding and activation. Proteins, 80, 1948-1961. https://doi.org/10.1002/prot.24077
Dautzenberg, F. M., Wichmann, J., Higelin, J., Py-Lang, G., Kratzeisen, C., Malherbe, P., Kilpatrick, G. J., & Jenck, F. (2001). Pharmacological characterization of the novel nonpeptide orphanin FQ/nociceptin receptor agonist Ro 64-6198: Rapid and reversible desensitization of the ORL1 receptor in vitro and lack of tolerance in vivo. Journal of Pharmacology and Experimental Therapeutics, 298, 812-819.
Décaillot, F. M., Rozenfeld, R., Gupta, A., & Devi, L. A. (2008). Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4. Proceedings of the National Academy of Sciences of the United States of America, 105, 16045-16050.
Degrandmaison, J., Abdallah, K., Blais, V., Génier, S., Lalumière, M. P., Bergeron, F., Cahill, C. M., Boulter, J., Lavoie, C. L., Parent, J. L., & Gendron, L. (2020). In vivo mapping of a GPCR interactome using knockin mice. Proceedings of the National Academy of Sciences of the United States of America, 117, 201917906.
Deng, H., Yang, Z., Li, Y., Bao, G., Friedrich, T., Gu, Q., Shen, X., & Schwarz, W. (2009). Interactions of Na+, K+-ATPase and co-expressed δ-opioid receptor. Neuroscience Research, 65, 222-227.
Deretic, D. (2006). A role for rhodopsin in a signal transduction cascade that regulates membrane trafficking and photoreceptor polarity. Vision Research, 46, 4427-4433. https://doi.org/10.1016/j.visres.2006.07.028
Derouiche, L., Pierre, F., Doridot, S., Ory, S., & Massotte, D. (2020). Heteromerization of endogenous mu and delta opioid receptors induces ligand-selective co-targeting to lysosomes. Molecules, 25, 4493.
Doly, S., & Marullo, S. (2015). Gatekeepers controlling GPCR export and function. Trends in Pharmacological Sciences, 36, 636-644. https://doi.org/10.1016/j.tips.2015.06.007
Dong, C., Filipeanu, C. M., Duvernay, M. T., & Wu, G. (2007). Regulation of G protein-coupled receptor export trafficking. Biochimica et Biophysica Acta - Biomembranes, 1768, 853-870.
Dong, C., & Wu, G. (2006). Regulation of anterograde transport of α2-adrenergic receptors by the N termini at multiple intracellular compartments. Journal of Biological Chemistry, 281, 38543-38554. https://doi.org/10.1074/jbc.M605734200
Dong, C., Yang, L., Zhang, X., Gu, H., Lam, M. L., Claycomb, W. C., Xia, H., & Wu, G. (2010). Rab8 interacts with distinct motifs in α2B- and β2-adrenergic receptors and differentially modulates their transport. Journal of Biological Chemistry, 285, 20369-20380.
Dong, S., Liu, J., Li, L., Wang, H., Ma, H., Zhao, Y., & Zhao, J. (2019). The HECT ubiquitin E3 ligase Smurf2 degrades µ-opioid receptor 1 in the ubiquitin-proteasome system in lung epithelial cells. American Journal of Physiology-Cell Physiology, 316, C632-C640.
Donica, C. L., Awwad, H. O., Thakker, D. R., & Standifer, K. M. (2013). Cellular mechanisms of nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor regulation and heterologous regulation by N/OFQ. Molecular Pharmacology, 83, 907-918.
Dores, M. R., Lin, H., Grimsey, N. J., Mendez, F., & Trejo, J. (2015). The α-Arrestin ARRDC3 mediates ALIX ubiquitination and G protein-coupled receptor lysosomal sorting. Molecular Biology of the Cell, 26, 4660-4673.
Drake, M. T., Shenoy, S. K., & Lefkowitz, R. J. (2006). Trafficking of G protein-coupled receptors. Circulation Research, 99, 570-582.
Dripps, I. J., Wang, Q., Neubig, R. R., Rice, K. C., Traynor, J. R., & Jutkiewicz, E. M. (2017). The role of regulator of G protein signaling 4 in delta-opioid receptor-mediated behaviors. Psychopharmacology, 234, 29-39.
Dupré, D. J., Robitaille, M., Richer, M., Éthier, N., Mamarbachi, A. M., & Hébert, T. E. (2007). Dopamine receptor-interacting protein 78 acts as a molecular chaperone for Ggamma subunits before assembly with Gbeta. Journal of Biological Chemistry, 282, 13703-13715.
Duvernay, M. T., Dong, C., Zhang, X., Zhou, F., Nichols, C. D., & Wu, G. (2009). Anterograde trafficking of G protein-coupled receptors: Function of the C-terminal F(X)6LL motif in export from the endoplasmic reticulum. Molecular Pharmacology, 75, 751-761.
Duvernay, M. T., Filipeanu, C. M., & Wu, G. (2005). The regulatory mechanisms of export trafficking of G protein-coupled receptors. Cellular Signalling, 17, 1457-1465.
Duvernay, M. T., Wang, H., Dong, C., Guidry, J. J., Sackett, D. L., & Wu, G. (2011). α2B-Adrenergic receptor interaction with tubulin controls its transport from the endoplasmic reticulum to the cell surface. Journal of Biological Chemistry, 286, 14080-14089.
Duvernay, M. T., Zhou, F., & Wu, G. (2004). A conserved motif for the transport of G protein-coupled receptors from the endoplasmic reticulum to the cell surface. Journal of Biological Chemistry, 279, 30741-30750.
Eason, M. G., Jacinto, M. T., Theiss, C. T., & Liggett, S. B. (1994). The palmitoylated cysteine of the cytoplasmic tail of α(2A)-adrenergic receptors confers subtype-specific agonist-promoted downregulation. Proceedings of the National Academy of Sciences of the United States of America, 91, 11178-11182.
El Kouhen, R., Burd, A. L., Erickson-Herbrandson, L. J., Chang, C. Y., Law, P. Y., & Loh, H. H. (2001). Phosphorylation of Ser363, Thr370, and Ser375 residues within the carboxyl tail differentially regulates μ-opioid receptor internalization. Journal of Biological Chemistry, 276, 12774-12780.
Escribá, P. V., Wedegaertner, P. B., Goñi, F. M., & Vögler, O. (2007). Lipid-protein interactions in GPCR-associated signaling. Biochimica et Biophysica Acta - Biomembranes, 1768, 836-852.
Esseltine, J. L., Dale, L. B., & Ferguson, S. S. G. (2011). Rab GTPases bind at a common site within the angiotensin II type I receptor carboxyl-terminal tail: Evidence that Rab4 regulates receptor phosphorylation, desensitization, and resensitization. Molecular Pharmacology, 79, 175-184.
Esseltine, J. L., & Ferguson, S. S. G. (2013). Regulation of G protein-coupled receptor trafficking and signaling by Rab GTPases. Small GTPases, 4, 132-135. https://doi.org/10.4161/sgtp.24304
Feng, P., Rahim, R. T., Cowan, A., Liu-Chen, L. Y., Peng, X., Gaughan, J., Meissler, J. J., Jr., Adler, M. W., & Eisenstein, T. K. (2006). Effects of mu, kappa or delta opioids administered by pellet or pump on oral Salmonella infection and gastrointestinal transit. European Journal of Pharmacology, 534, 250-257.
Fourriere, L., Jimenez, A. J., Perez, F., & Boncompain, G. (2020). The role of microtubules in secretory protein transport. Journal of Cell Science, 133, jcs237016.
Fraser, G. L., Gaudreau, G. A., Clarke, P. B., Ménard, D. P., & Perkins, M. N. (2000). Antihyperalgesic effects of delta opioid agonists in a rat model of chronic inflammation. British Journal of Pharmacology, 129, 1668-1672.
Gabilondo, A. M., Hegler, J., Krasel, C., Boivin-Jahns, V., Hein, L., & Lohse, M. J. (1997). A dileucine motif in the C terminus of the β2-adrenergic receptor is involved in receptor internalization. Proceedings of the National Academy of Sciences of the United States of America, 94, 12285-12290.
Gage, R. M., Kim, K. A., Cao, T. T., & Von Zastrow, M. (2001). A transplantable sorting signal that is sufficient to mediate rapid recycling of G protein-coupled receptors. Journal of Biological Chemistry, 276, 44712-44720.
Gallantine, E. L., & Meert, T. F. (2005). A comparison of the antinociceptive and adverse effects of the mu-opioid agonist morphine and the delta-opioid agonist SNC80. Basic & Clinical Pharmacology & Toxicology, 97, 39-51.
Gassmann, M., Shaban, H., Vigot, R., Sansig, G., Haller, C., Barbieri, S., Humeau, Y., Schuler, V., Müller, M., Kinzel, B., & Klebs, K. (2004). Redistribution of GABAB(1) protein and atypical GABAB responses in GABAB(2)-deficient mice. Journal of Neuroscience, 24, 6086-6097.
Ge, X., Loh, H. H., & Law, P.-Y. (2009). mu-Opioid receptor cell surface expression is regulated by its direct interaction with Ribophorin I. Molecular Pharmacology, 75, 1307-1316.
Geisler, C., Dietrich, J., Nielsen, B. L., Kastrup, J., Lauritsen, J. P., Ødum, N., & Christensen, M. D. (1998). Leucine-based receptor sorting motifs are dependent on the spacing relative to the plasma membrane. Journal of Biological Chemistry, 273, 21316-21323.
Gelernter, J., & Kranzler, H. R. (2000). Variant detection at the δ opioid receptor (OPRD1) locus and population genetics of a novel variant affecting protein sequence. Human Genetics, 107, 86-88.
Gendron, L., Cahill, C. M., Von Zastrow, M., Schiller, P. W., & Pineyro, G. (2016). Molecular pharmacology of δ-opioid receptors. Pharmacological Reviews, 68, 631-700.
Gendron, L., Lucido, A. L., Mennicken, F., O'Donnell, D., Vincent, J. P., Stroh, T., & Beaudet, A. (2006). Morphine and pain-related stimuli enhance cell surface availability of somatic delta-opioid receptors in rat dorsal root ganglia. Journal of Neuroscience, 26, 953-962.
Génier, S., Degrandmaison, J., Moreau, P., Labrecque, P., Hébert, T. E., & Parent, J. L. (2016). Regulation of GPCR expression through an interaction with CCT7, a subunit of the CCT/TRiC complex. Molecular Biology of the Cell, 27, 3800-3812.
Georgoussi, Z., Leontiadis, L., Mazarakou, G., Merkouris, M., Hyde, K., & Hamm, H. (2006). Selective interactions between G protein subunits and RGS4 with the C-terminal domains of the μ- and δ-opioid receptors regulate opioid receptor signaling. Cellular Signalling, 18, 771-782.
Gomes, I., Ayoub, M. A., Fujita, W., Jaeger, W. C., Pfleger, K. D., & Devi, L. A. (2015). G protein-coupled receptor heteromers. Annual Review of Pharmacology and Toxicology, 56, 403-425.
Goth, C. K., Petäjä-Repo, U. E., & Rosenkilde, M. M. (2020). G protein-coupled receptors in the sweet spot: Glycosylation and other post-translational modifications. ACS Pharmacology & Translational Science, 3, 237-245.
Goth, C. K., Tuhkanen, H. E., Khan, H., Lackman, J. J., Wang, S., Narimatsu, Y., Hansen, L. H., Overall, C. M., Clausen, H., Schjoldager, K. T., & Petäjä-Repo, U. E. (2017). Site-specific O-glycosylation by polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-transferase T2) co-regulates β1-adrenergic receptor N-terminal cleavage. Journal of Biological Chemistry, 292, 4714-4726.
Grisel, J. E., Mogil, J. S., Belknap, J. K., & Grandy, D. K. (1996). Orphanin FQ acts as a supraspinal, but not a spinal, anti-opioid peptide. NeuroReport, 7, 2125-2129. https://doi.org/10.1097/00001756-199609020-00012
Groer, C. E., Schmid, C. L., Jaeger, A. M., & Bohn, L. M. (2011). Agonist-directed interactions with specific β-arrestins determine μ-opioid receptor trafficking, ubiquitination, and dephosphorylation. Journal of Biological Chemistry, 286, 31731-31741.
Guan, J. S., Xu, Z. Z., Gao, H., He, S. Q., Ma, G. Q., Sun, T., Wang, L. H., Zhang, Z. N., Lena, I., Kitchen, I., & Elde, R. (2005). Interaction with vesicle luminal protachykinin regulates surface expression of δ-opioid receptors and opioid analgesia. Cell, 122, 619-631.
Gullapalli, A., Garrett, T. A., Paing, M. M., Griffin, C. T., Yang, Y., & Trejo, J. (2004). A role for sorting nexin 2 in epidermal growth factor receptor down-regulation: Evidence for distinct functions of sorting nexin 1 and 2 in protein trafficking. Molecular Biology of the Cell, 15, 2143-2155.
Hall, R. A., Ostedgaard, L. S., Premont, R. T., Blitzer, J. T., Rahman, N., Welsh, M. J., & Lefkowitz, R. J. (1998). A C-terminal motif found in the β2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins. Proceedings of the National Academy of Sciences of the United States of America, 95, 8496-8501.
Hall, R. A., Premont, R. T., Chow, C. W., Blitzer, J. T., Pitcher, J. A., Claing, A., Stoffel, R. H., Barak, L. S., Shenolikar, S., Weinman, E. J., & Grinstein, S. (1998). The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange. Nature, 392, 626-630.
Hammad, M. M., Kuang, Y. Q., Morse, A., & Dupré, D. J. (2012). Rab1 interacts directly with the β2-adrenergic receptor to regulate receptor anterograde trafficking. Biological Chemistry, 393, 541-546.
Hasbi, A., Allouche, S., Sichel, F., Stanasila, L., Massotte, D., Landemore, G., Polastron, J., & Jauzac, P. (2000). Internalization and recycling of delta-opioid receptor are dependent on a phosphorylation-dephosphorylation mechanism. Journal of Pharmacology and Experimental Therapeutics, 293, 237-247.
Hauser, A. S., Attwood, M. M., Rask-Andersen, M., Schiöth, H. B., & Gloriam, D. E. (2017). Trends in GPCR drug discovery: New agents, targets and indications. Nature Reviews Drug Discovery, 16, 829-842.
He, X., Sandhu, H. K., Yang, Y., Hua, F., Belser, N., Kim, D. H., & Xia, Y. (2013). Neuroprotection against hypoxia/ischemia: δ-opioid receptor-mediated cellular/molecular events. Cellular and Molecular Life Sciences, 70, 2291-2303.
Head, B. P., Patel, H. H., Roth, D. M., Lai, N. C., Niesman, I. R., Farquhar, M. G., & Insel, P. A. (2005). G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. Journal of Biological Chemistry, 280, 31036-31044.
Headrick, J. P., See Hoe, L. E., Du Toit, E. F., & Peart, J. N. (2015). Opioid receptors and cardioprotection-“Opioidergic conditioning” of the heart. British Journal of Pharmacology, 172, 2026-2050.
Henry, A. G., Hislop, J. N., Grove, J., Thorn, K., Marsh, M., & von Zastrow, M. (2012). Regulation of endocytic clathrin dynamics by cargo ubiquitination. Developmental Cell, 23, 519-532.
Henry, A. G., White, I. J., Marsh, M., von Zastrow, M., & Hislop, J. N. (2011). The role of ubiquitination in lysosomal trafficking of δ-opioid receptors. Traffic, 12, 170-184.
Heydorn, A., Søndergaard, B. P., Ersbøll, B., Holst, B., Nielsen, F. C., Haft, C. R., Whistler, J., & Schwartz, T. W. (2004). A library of 7TM receptor C-terminal tails: Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP). Journal of Biological Chemistry, 279, 54291-54303.
Hirst, J., Bright, N. A., Rous, B., & Robinson, M. S. (1999). Characterization of a fourth adaptor-related protein complex. Molecular Biology of the Cell, 10, 2787-2802.
Hislop, J. N., Henry, A. G., Marchese, A., & von Zastrow, M. (2009). Ubiquitination regulates proteolytic processing of G protein-coupled receptors after their sorting to lysosomes. Journal of Biological Chemistry, 284, 19361-19370.
Hislop, J. N., Henry, A. G., & Von Zastrows, M. (2011). Ubiquitination in the first cytoplasmic loop of μ-opioid receptors reveals a hierarchical mechanism of lysosomal down-regulation. Journal of Biological Chemistry, 286, 40193-40204.
Holdridge, S. V., & Cahill, C. M. (2007). Spinal administration of a δ opioid receptor agonist attenuates hyperalgesia and allodynia in a rat model of neuropathic pain. European Journal of Pain, 11, 685-693.
Huang, P., Steplock, D., Weinman, E. J., Hall, R. A., Ding, Z., Li, J., Wang, Y., & Liu-Chen, L. Y. (2004). κ opioid receptor interacts with Na+/H +-exchanger regulatory factor-1/Ezrin-radixin-moesin-binding phosphoprotein-50 (NHERF-1/EBP50) to stimulate Na+/H+ exchange independent of Gi/Go proteins. Journal of Biological Chemistry, 279, 25002-25009.
Hunyady, L., Bor, M., Baukal, A. J., Balla, T., & Catt, K. J. (1995). A conserved NPLFY sequence contributes to agonist binding and signal transduction but is not an internalization signal for the type 1 angiotensin II receptor. Journal of Biological Chemistry, 270, 16602-16609.
Innamorati, G., Sadeghi, H. M., Tran, N. T., & Birnbaumer, M. (1998). A serine cluster prevents recycling of the V2 vasopressin receptor. Proceedings of the National Academy of Sciences of the United States of America, 95, 2222-2226.
Kamei, J., Kawai, K., Mizusuna, A., Saitoh, A., Morita, K., Narita, M., Tseng, L. F., & Nagase, H. (1997). Supraspinal δ1-opioid receptor-mediated antinociceptive properties of (-)-TAN-67 in diabetic mice. European Journal of Pharmacology, 322, 27-30.
Karoussiotis, C., Marti-Solano, M., Stepniewski, T. M., Symeonof, A., Selent, J., & Georgoussi, Z. (2020). A highly conserved δ-opioid receptor region determines RGS4 interaction. FEBS Journal, 287, 736-748. https://doi.org/10.1111/febs.15033
Kim, K. A., & Von Zastrow, M. (2003). Neurotrophin-regulated sorting of opioid receptors in the biosynthetic pathway of neurosecretory cells. Journal of Neuroscience, 23, 2075-2085.
Kniazeff, J., Galvez, T., Labesse, G., & Pin, J. P. (2002). No ligand binding in the GB2 subunit of the GABAB receptor is required for activation and allosteric interaction between the subunits. Journal of Neuroscience, 22, 7352-7361.
Ko, J. L., Arvidsson, U., Williams, F. G., Law, P. Y., Elde, R., & Loh, H. H. (1999). Visualization of time-dependent redistribution of δ-opioid receptors in neuronal cells during prolonged agonist exposure. Molecular Brain Research, 69, 171-185.
Koliwer, J., Park, M., Bauch, C., Von Zastrow, M., & Kreienkamp, H. J. (2015). The golgi-associated PDZ domain protein PIST/GOPC stabilizes the β1-Adrenergic receptor in intracellular compartments after internalization. Journal of Biological Chemistry, 290, 6120-6129.
Kramer, H. K., Andria, M. L., Kushner, S. A., Esposito, D. H., Hiller, J. M., & Simon, E. J. (2000). Mutation of tyrosine 318 (Y318F) in the delta-opioid receptor attenuates tyrosine phosphorylation, agonist-dependent receptor internalization, and mitogen-activated protein kinase activation. Molecular Brain Research, 79, 55-66.
Kuang, Y. Q., Charette, N., Frazer, J., Holland, P. J., Attwood, K. M., Dellaire, G., & Dupre, D. J. (2012). Dopamine receptor-interacting protein 78 acts as a molecular chaperone for CCR5 chemokine receptor signaling complex organization. PLoS ONE, 7, e40522.
Kurten, R. C., Cadena, D. L., & Gill, G. N. (1996). Enhanced degradation of EGF receptors by a sorting nexin, SNX1. Science, 272, 1008-1010.
Lackman, J. J., Goth, C. K., Halim, A., Vakhrushev, S. Y., Clausen, H., & Petäjä-Repo, U. E. (2018). Site-specific O-glycosylation of N-terminal serine residues by polypeptide GalNAc-transferase 2 modulates human δ-opioid receptor turnover at the plasma membrane. Cellular Signalling, 42, 184-193.
Lapalu, S., Moisand, C., Mazarguil, H., Cambois, G., Mollereau, C., & Meunier, J. C. (1997). Comparison of the structure-activity relationships of nociceptin and dynorphin A using chimeric peptides. FEBS Letters, 417, 333-336.
Laporte, S. A., Servant, G., Richard, D. E., Escher, E., Guillemette, G., & Leduc, R. (1996). The tyrosine within the NPXnY motif of the human angiotensin II type 1 receptor is involved in mediating signal transduction but is not essential for internalization. Molecular Pharmacology, 49, 89-95.
Le Gouill, C., Parent, J. L., Rola-Pleszczynski, M., & Staňková, J. (1997). Structural and functional requirements for agonist-induced internalization of the human platelet-activating factor receptor. Journal of Biological Chemistry, 272, 21289-21295.
Leclerc, P. C., Auger-Messier, M., Lanctot, P. M., Escher, E., Leduc, R., & Guillemette, G. (2002). A polyaromatic caveolin-binding-like motif in the cytoplasmic tail of the type 1 receptor for angiotensin II plays an important role in receptor trafficking and signaling. Endocrinology, 143, 4702-4710. https://doi.org/10.1210/en.2002-220679
Lemos Duarte, M., & Devi, L. A. (2020). Post-translational modifications of opioid receptors. Trends in Neurosciences, 43, 417-432. https://doi.org/10.1016/j.tins.2020.03.011
Leontiadis, L. J., Papakonstantinou, M. P., & Georgoussi, Z. (2009). Regulator of G protein signaling 4 confers selectivity to specific G proteins to modulate μ- and δ-opioid receptor signaling. Cellular Signalling, 21, 1218-1228.
Leskelä, T. T., Lackman, J. J., Vierimaa, M. M., Kobayashi, H., Bouvier, M., & Petäjä-Repo, U. E. (2012). Cys-27 variant of human δ-opioid receptor modulates maturation and cell surface delivery of Phe-27 variant via heteromerization. Journal of Biological Chemistry, 287, 5008-5020.
Leskelä, T. T., Markkanen, P. M. H., Pietilä, E. M., Tuusa, J. T., & Petäjä-Repo, U. E. (2007). Opioid receptor pharmacological chaperones act by binding and stabilizing newly synthesized receptors in the endoplasmic reticulum. Journal of Biological Chemistry, 282, 23171-23183.
Letourneur, F., Gaynor, E. C., Hennecke, S., Demolliere, C., Duden, R., Emr, S. D., Riezman, H., & Cosson, P. (1994). Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum. Cell, 79, 1199-1207.
Li, C., Fan, Y., Lan, T. H., Lambert, N. A., & Wu, G. (2012). Rab26 modulates the cell surface transport of α2- adrenergic receptors from the Golgi. Journal of Biological Chemistry, 287, 42784-42794.
Li, C., Wei, Z., Fan, Y. I., Huang, W., Su, Y., Li, H., Dong, Z., Fukuda, M., Khater, M., & Wu, G. (2017). The GTPase Rab43 controls the anterograde ER-golgi trafficking and sorting of GPCRs. Cell Reports, 21, 1089-1101. https://doi.org/10.1016/j.celrep.2017.10.011
Li, J. G., Chen, C., Huang, P., Wang, Y., & Liu-Chen, L. Y. (2012). 14-3-3ζ Protein regulates anterograde transport of the human κ-opioid receptor (hKOPR). Journal of Biological Chemistry, 287, 37778-37792.
Li, J. G., Chen, C., & Liu-Chen, L. Y. (2002). Ezrin-radixin-moesin-binding phosphoprotein-50/Na+/H+ exchanger regulatory factor (EBP50/NHERF) blocks U50,488H-induced down-regulation of the human κ opioid receptor by enhancing its recycling rate. Journal of Biological Chemistry, 277, 27545-27552.
Li, J. G., Chen, C., & Liu-Chen, L. Y. (2007). N-glycosylation of the human κ opioid receptor enhances its stability but slows its trafficking along the biosynthesis pathway. Biochemistry, 46, 10960-10970.
Li, J. G., Haines, D. S., & Liu-Chen, L. Y. (2008). Agonist-promoted Lys63-linked polyubiquitination of the human κ-opioid receptor is involved in receptor down-regulation. Molecular Pharmacology, 73, 1319-1330.
Li, T., Snyder, W. K., Olsson, J. E., & Dryja, T. P. (1996). Transgenic mice carrying the dominant rhodopsin mutation P347S: Evidence for defective vectorial transport of rhodopsin to the outer segments. Proceedings of the National Academy of Sciences of the United States of America, 93, 14176-14181.
Liang, Y. J., Wu, D. F., Stumm, R., Höllt, V., & Koch, T. (2008). Membrane glycoprotein M6A promotes μ-opioid receptor endocytosis and facilitates receptor sorting into the recycling pathway. Cell Research, 18, 768-779.
Lobingier, B. T., Hüttenhain, R., Eichel, K., Miller, K. B., Ting, A. Y., von Zastrow, M., & Krogan, N. J. (2017). An approach to spatiotemporally resolve protein interaction networks in living cells. Cell, 169, 350-360.e12.
Lobingier, B. T., & von Zastrow, M. (2019). When trafficking and signaling mix: How subcellular location shapes G protein-coupled receptor activation of heterotrimeric G proteins. Traffic, 20, 130-136. https://doi.org/10.1111/tra.12634
Lucido, A. L., Morinville, A., Gendron, L., Stroh, T., & Beaudet, A. (2005). Prolonged morphine treatment selectively increases membrane recruitment of δ-opioid receptors in mouse basal ganglia. Journal of Molecular Neuroscience, 25, 207-213.
Ma, D., Zerangue, N., Lin, Y. F., Collins, A., Yu, M., Jan, Y. N., & Jan, L. Y. (2001). Role of ER export signals in controlling surface potassium channel numbers. Science, 291, 316-319.
Ma, J., Zhang, Y., Kalyuzhny, A. E., & Pan, Z. Z. (2006). Emergence of functional δ-opioid receptors induced by long-term treatment with morphine. Molecular Pharmacology, 69, 1137-1145.
Ma, W., & Goldberg, J. (2013). Rules for the recognition of dilysine retrieval motifs by coatomer. EMBO Journal, 32, 926-937.
Madeira, F., Tinti, M., Murugesan, G., Berrett, E., Stafford, M., Toth, R., Cole, C., MacKintosh, C., & Barton, G. J. (2015). 14-3-3-Pred: Improved methods to predict 14-3-3-binding phosphopeptides. Bioinformatics, 31, 2276-2283. https://doi.org/10.1093/bioinformatics/btv133
Mague, S. D., Pliakas, A. M., Todtenkopf, M. S., Tomasiewicz, H. C., Zhang, Y., Stevens, W. C., Jones, R. M., Portoghese, P. S., & Carlezon, W. A. (2003). Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in rats. Journal of Pharmacology and Experimental Therapeutics, 305, 323-330.
Malaga-Dieguez, L., Yang, Q., Bauer, J., Pankevych, H., Freissmuth, M., & Nanoff, C. (2010). Pharmacochaperoning of the A1 adenosine receptor is contingent on the endoplasmic reticulum. Molecular Pharmacology, 77, 940-952.
Mann, A., Moulédous, L., Froment, C., O’Neill, P. R., Dasgupta, P., Günther, T., Brunori, G., Kieffer, B. L., Toll, L., Bruchas, M. R., & Zaveri, N. T. (2019). Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists. Science Signaling, 12, 574.
Margeta-Mitrovic, M., Jan, Y. N., & Jan, L. Y. (2000). A trafficking checkpoint controls GABA(B) receptor heterodimerization. Neuron, 27, 97-106. https://doi.org/10.1016/S0896-6273(00)00012-X
Markkanen, P. M. H., & Petäjä-Repo, U. E. (2008). N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded δ-opioid receptors at the cell surface. Journal of Biological Chemistry, 283, 29086-29098.
Masuho, I., Balaji, S., Muntean, B. S., Skamangas, N. K., Chavali, S., Tesmer, J. J., Babu, M. M., & Martemyanov, K. A. (2020). A global map of G protein signaling regulation by RGS proteins. Cell, 183, 503-521.e19.
Mazelova, J., Astuto-Gribble, L., Inoue, H., Tam, B. M., Schonteich, E., Prekeris, R., Moritz, O. L., Randazzo, P. A., & Deretic, D. (2009). Ciliary targeting motif VxPx directs assembly of a trafficking module through Arf4. EMBO Journal, 28, 183-192. https://doi.org/10.1038/emboj.2008.267
McMahon, H. T., & Mills, I. G. (2004). COP and clathrin-coated vesicle budding: Different pathways, common approaches. Current Opinion in Cell Biology, 16, 379-391.
Merkouris, M., Dragatsis, I., Megaritis, G., Konidakis, G., Zioudrou, C., Milligan, G., & Georgoussi, Z. (1996). Identification of the critical domains of the δ-opioid receptor involved in G protein coupling using site-specific synthetic peptides. Molecular Pharmacology, 50, 985-993.
Meunier, J. C., Mollereau, C., Toll, L., Suaudeau, C., Moisand, C., Alvinerie, P., Butour, J. L., Guillemot, J. C., Ferrara, P., Monsarrat, B., & Mazarguil, H. (1995). Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature, 377, 532-535.
Michineau, S., Alhenc-Gelas, F., & Rajerison, R. M. (2006). Human bradykinin B2 receptor sialylation and N-glycosylation participate with bisulfide bonding in surface receptor dimerization. Biochemistry, 45, 2699-2707.
Mitchell, R., Robertson, D. N., Holland, P. J., Collins, D., Lutz, E. M., & Johnson, M. S. (2003). ADP-ribosylation factor-dependent phospholipase D activation by the M3 muscarinic receptor. Journal of Biological Chemistry, 278, 33818-33830.
Mizuno, M., & Singer, S. J. (1994). A possible role for stable microtubules in intracellular transport from the endoplasmic reticulum to the Golgi apparatus. Journal of Cell Science, 107, 1321-1331. https://doi.org/10.1242/jcs.107.5.1321
Moench, S. J., Moreland, J., Stewart, D. H., & Dewey, T. G. (1994). Fluorescence studies of the location and membrane accessibility of the palmitoylation sites of rhodopsin. Biochemistry, 33, 5791-5796. https://doi.org/10.1021/bi00185a017
Mogil, J. S., Grisel, J. E., Reinscheid, R. K., Civelli, O., Belknap, J. K., & Grandy, D. K. (1996). Orphanin FQ is a functional anti-opioid peptide. Neuroscience, 75, 333-337. https://doi.org/10.1016/0306-4522(96)00338-7
Mogil, J. S., Grisel, J. E., Zhangs, G., Belknap, J. K., & Grandy, D. K. (1996). Functional antagonism of μ-, δ- and κ-opioid antinociception by orphanin FQ. Neuroscience Letters, 214, 131-134.
Mogil, J. S., & Pasternak, G. W. (2001). The molecular and behavioral pharmacology of the orphanin FQ/nociceptin peptide and receptor family. Pharmacological Reviews, 53, 381-415.
Mollereau, C., Mouledous, L., Lapalu, S., Cambois, G., Moisand, C., Butour, J. L., & Meunier, J. C. (1999). Distinct mechanisms for activation of the opioid receptor-like 1 and κ-opioid receptors by nociceptin and dynorphin A. Molecular Pharmacology, 55, 324-331.
Morgan, M. M., & Christie, M. J. (2011). Analysis of opioid efficacy, tolerance, addiction and dependence from cell culture to human. British Journal of Pharmacology, 164, 1322-1334.
Morinville, A., Cahill, C. M., Aibak, H., Rymar, V. V., Pradhan, A., Hoffert, C., Mennicken, F., Stroh, T., Sadikot, A. F., O'Donnell, D., & Clarke, P. B. (2004). Morphine-induced changes in delta opioid receptor trafficking are linked to somatosensory processing in the rat spinal cord. Journal of Neuroscience, 24, 5549-5559.
Murthy, A., Gonzalez-Agosti, C., Cordero, E., Pinney, D., Candia, C., Solomon, F., Gusella, J., & Ramesh, V. (1998). NHE-RF, a regulatory cofactor for Na+ -H+ exchange, is a common interactor for merlin and ERM (MERM) proteins. Journal of Biological Chemistry, 273, 1273-1276.
Naumenko, V. S., & Ponimaskin, E. (2018). Palmitoylation as a functional regulator of neurotransmitter receptors. Neural Plasticity, 2018, 5701348.
Navarro, G., Borroto-Escuela, D. O., Fuxe, K., & Franco, R. (2014). Potential of caveolae in the therapy of cardiovascular and neurological diseases. Frontiers in Physiology, 5, 1-8.
Neilan, C. L., Akil, H., Woods, J. H., & Traynor, J. R. (1999). Constitutive activity of the δ-opioid receptor expressed in C6 glioma cells: Identification of non-peptide δ-inverse agonists. British Journal of Pharmacology, 128, 556-562.
Nisar, S., Kelly, E., Cullen, P. J., & Mundell, S. J. (2010). Regulation of P2Y1 receptor traffic by sorting nexin 1 is retromer independent. Traffic, 11, 508-519.
Nishimura, N., & Balch, W. E. (1997). A diacidic signal required for selective export from the endoplasmic reticulum. Science, 277, 556-558. https://doi.org/10.1126/science.277.5325.556
Nishimura, N., Bannykh, S., Slabough, S., Matteson, J., Altschuler, Y., Hahn, K., & Balch, W. E. (1999). A diacidic (DXE) code directs concentration of cargo during export from the endoplasmic reticulum. Journal of Biological Chemistry, 274, 15937-15946.
Nozaki, C., Nagase, H., Nemoto, T., Matifas, A., Kieffer, B. L., & Gaveriaux-Ruff, C. (2014). In vivo properties of KNT-127, a novel δ opioid receptor agonist: Receptor internalization, antihyperalgesia and antidepressant effects in mice. British Journal of Pharmacology, 171, 5376-5386.
Petäjä-Repo, U. E., Hogue, M., Laperrière, A., Bhalla, S., Walker, P., & Bouvier, M. (2001). Newly synthesized human δ opioid receptors retained in the endoplasmic reticulum are retrotranslocated to the cytosol, deglycosylated, ubiquitinated, and degraded by the proteasome. Journal of Biological Chemistry, 276, 4416-4423.
O’Brien, J. B., Wilkinson, J. C., & Roman, D. L. (2019). Regulator of G-protein signaling (RGS) proteins as drug targets: Progress and future potentials. Journal of Biological Chemistry, 294, 18571-18585.
Ohno, H., Fournier, M. C., Poy, G., & Bonifacino, J. S. (1996). Structural determinants of interaction of tyrosine-based sorting signals with the adaptor medium chains. Journal of Biological Chemistry, 271, 29009-29015.
Ohno, H., Stewart, J., Fournier, M. C., Bosshart, H., Rhee, I., Miyatake, S., Saito, T., Gallusser, A., Kirchhausen, T., & Bonifacino, J. S. (1995). Interaction of tyrosine-based sorting signals with clathrin-associated proteins. Science, 269, 1872-1875.
Ong, E., & Cahill, C. (2014). Molecular perspectives for mu/delta opioid receptor heteromers as distinct, functional receptors. Cells, 3, 152-179.
Ong, E. W., Xue, L., Olmstead, M. C., & Cahill, C. M. (2015). Prolonged morphine treatment alters δ opioid receptor post-internalization trafficking. British Journal of Pharmacology, 172, 615-629.
Onoprishvili, I., Andria, M. L., Kramer, H. K., Ancevska-Taneva, N., Hiller, J. M., & Simon, E. J. (2003). Interaction between the μ opioid receptor and filamin A is involved in receptor regulation and trafficking. Molecular Pharmacology, 64, 1092-1100.
Oo, M. L., Chang, S. H., Thangada, S., Wu, M. T., Rezaul, K., Blaho, V., Hwang, S. I., Han, D. K., & Hla, T. (2011). Engagement of S1P1-degradative mechanisms leads to vascular leak in mice. Journal of Clinical Investigation, 121, 2290-2300.
Orsini, M. J., Parent, J.-L., Mundell, S. J., & Benovic, J. L. (1999). Trafficking of the HIV coreceptor CXCR4. Journal of Biological Chemistry, 274, 31076-31086.
Otis, V., Sarret, P., & Gendron, L. (2011). Spinal activation of delta opioid receptors alleviates cancer-related bone pain. Neuroscience, 183, 221-229. https://doi.org/10.1016/j.neuroscience.2011.03.052
Pagano, A., Rovelli, G., Mosbacher, J., Lohmann, T., Duthey, B., Stauffer, D., Ristig, D., Schuler, V., Meigel, I., Lampert, C., & Stein, T. (2001). C-terminal interaction is essential for surface trafficking but not for heteromeric assembly of GABAB receptors. Journal of Neuroscience, 21, 1189-1202.
Paing, M. M., Johnston, C. A., Siderovski, D. P., & Trejo, J. (2006). Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization. Molecular and Cellular Biology, 26, 3231-3242.
Papakonstantinou, M. P., Karoussiotis, C., & Georgoussi, Z. (2015). RGS2 and RGS4 proteins: New modulators of the κ-opioid receptor signaling. Cellular Signalling, 27, 104-114.
Parent, A., Hamelin, E., Germain, P., & Parent, J.-L. (2009). Rab11 regulates the recycling of the beta2-adrenergic receptor through a direct interaction. Biochemical Journal, 418, 163-172.
Pasquini, F., Bochet, P., Garbay-Jaureguiberry, C., Roques, B. P., Rossier, J., & Beaudet, A. (1992). Electron microscopic localization of photoaffinity-labelled delta opioid receptors in the neostriatum of the rat. Journal of Comparative Neurology, 326, 229-244.
Patel, H. H., Head, B. P., Petersen, H. N., Niesman, I. R., Huang, D., Gross, G. J., Insel, P. A., & Roth, D. M. (2006). Protection of adult rat cardiac myocytes from ischemic cell death: Role of caveolar microdomains and δ-opioid receptors. American Journal of Physiology-Heart and Circulatory Physiology, 291, 344-350.
Patel, H. H., Murray, F., & Insel, P. A. (2008). Caveolae as organizers of pharmacologically relevant signal transduction molecules. Annual Review of Pharmacology and Toxicology, 48, 359-391.
Pathan, H., & Williams, J. (2012). Basic opioid pharmacology: An update. British Journal of Pain, 6, 11-16.
Peluso, J., LaForge, K. S., Matthes, H. W., Kreek, M. J., Kieffer, B. L., & Gavériaux-Ruff, C. (1998). Distribution of nociceptin/orphanin FQ receptor transcript in human central nervous system and immune cells. Journal of Neuroimmunology, 81, 184-192.
Petäjä-Repo, U. E., Hogue, M., Bhalla, S., Laperrière, A., Morello, J. P., & Bouvier, M. (2002). Ligands act as pharmacological chaperones and increase the efficiency of delta opioid receptor maturation. EMBO Journal, 21, 1628-1637.
Petäjä-Repo, U. E., Hogue, M., Laperrière, A., Walker, P., & Bouvier, M. (2000). Export from the endoplasmic reticulum represents the limiting step in the maturation and cell surface expression of the human δ opioid receptor. Journal of Biological Chemistry, 275, 13727-13736.
Petäjä-Repo, U. E., Hogue, M., Leskelä, T. T., Markkanen, P. M., Tuusa, J. T., & Bouvier, M. (2006). Distinct subcellular localization for constitutive and agonist-modulated palmitoylation of the human delta opioid receptor. Journal of Biological Chemistry, 281, 15780-15789.
Petko, J., Justice-Bitner, S., Jin, J., Wong, V., Kittanakom, S., Ferraro, T. N., Stagljar, I., & Levenson, R. (2013). MOR is not enough: Identification of novel mu-opioid receptor interacting proteins using traditional and modified membrane yeast two-hybrid screens. PLoS ONE, 8, e67608.
Petrillo, P., Angelici, O., Bingham, S., Ficalora, G., Garnier, M., Zaratin, P. F., Petrone, G., Pozzi, O., Sbacchi, M., Stean, T. O., & Upton, N. (2003). Evidence for a selective role of the δ-opioid agonist [8R-(4bS*, 8aα,8aβ,12bβ )]7,10-dimethyl-1-methoxy-11-(2-methylpropyl)oxycarbonyl 5,6,7,8,12,12b-hexahydro-(9H)-4,8-methanobenzofuro[3,2-e]pyrrolo[2,3-g] isoquinoline Hydrochloride (SB-235863) in blocki. Journal of Pharmacology and Experimental Therapeutics, 307, 1079-1089.
Pfeiffer, A., Brantl, V., Herz, A., & Emrich, H. M. (1986). Psychotomimesis mediated by kappa opiate receptors. Science, 233, 774-776.
Pradhan, A. A., Becker, J. A., Scherrer, G., Tryoen-Toth, P., Filliol, D., Matifas, A., Massotte, D., Gavériaux-Ruff, C., & Kieffer, B. L. (2009). In vivo delta opioid receptor internalization controls behavioral effects of agonists. PLoS ONE, 4(5), e5425.
Preisser, L., Ancellin, N., Michaelis, L., Creminon, C., Morel, A., & Corman, B. (1999). Role of the carboxyl-terminal region, di-leucine motif and cysteine residues in signalling and internalization of vasopressin V1a receptor. FEBS Letters, 460, 303-308. https://doi.org/10.1016/S0014-5793(99)01360-5
Presley, J. F., Cole, N. B., Schroer, T. A., Hirschberg, K., Zaal, K. J. M., & Lippincott-Schwartz, J. (1997). ER-to-Golgi transport visualized in living cells. Nature, 389, 81-85. https://doi.org/10.1038/38001
Ramkumar, V., Olah, M. E., Jacobson, K. A., & Stiles, G. L. (1991). Distinct pathways of desensitization of A1- and A2-adenosine receptors in DDT1 MF-2 cells. Molecular Pharmacology, 40, 639-647.
Rankovic, M., Jacob, L., Rankovic, V., Brandenburg, L.-O., Schröder, H., Höllt, V., & Koch, T. (2009). ADP-ribosylation factor 6 regulates mu-opioid receptor trafficking and signaling via activation of phospholipase D2. Cellular Signalling, 21, 1784-1793. https://doi.org/10.1016/j.cellsig.2009.07.014
Reczek, D., Berryman, M., & Bretscher, A. (1997). Identification of EPB50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family. Journal of Cell Biology, 139, 169-179.
Reinscheid, R. K., Higelin, J., Henningsen, R. A., Monsma, F. J., & Civelli, O. (1998). Structures that delineate orphanin FQ and dynorphin A pharmacological selectivities. Journal of Biological Chemistry, 273, 1490-1495.
Reinscheid, R. K., Nothacker, H. P., Bourson, A., Ardati, A., Henningsen, R. A., Bunzow, J. R., Grandy, D. K., Langen, H., Monsma, F. J., & Civelli, O. (1995). Orphanin FQ: A neuropeptide that activates an opioidlike G protein-coupled receptor. Science, 270, 792-794.
Restituito, S., Couve, A., Bawagan, H., Jourdain, S., Pangalos, M. N., Calver, A. R., Freeman, K. B., & Moss, S. J. (2005). Multiple motifs regulate the trafficking of GABAB receptors at distinct checkpoints within the secretory pathway. Molecular and Cellular Neurosciences, 28, 747-756.
Robert, J., Clauser, E., Petit, P. X., & Ventura, M. A. (2005). A novel C-terminal motif is necessary for the export of the vasopressin V1b/V3 receptor to the plasma membrane. Journal of Biological Chemistry, 280, 2300-2308.
Robertson, D. N., Johnson, M. S., Moggach, L. O., Holland, P. J., Lutz, E. M., & Mitchell, R. (2003). Selective interaction of ARF1 with the carboxy-terminal tail domain of the 5-HT2A receptor. Molecular Pharmacology, 64, 1239-1250.
Rodrigues, A. R., Sousa, D., Almeida, H., & Gouveia, A. M. (2017). Cell surface targeting of the Melanocortin 5 Receptor (MC5R) requires serine-rich terminal motifs. Biochimica et Biophysica Acta - Molecular Cell Research, 1864, 1217-1226.
Rothman, J. E., & Orci, L. (1992). Molecular dissection of the secretory pathway. Nature, 355, 409-415. https://doi.org/10.1038/355409a0
Sadeghi, H., & Birnbaumer, M. (1999). O-glycosylation of the V2 vasopressin receptor. Glycobiology, 9, 731-737. https://doi.org/10.1093/glycob/9.7.731
Saitoh, A., Sugiyama, A., Yamada, M., Inagaki, M., Oka, J.-I., Nagase, H., & Yamada, M. (2013). The novel δ opioid receptor agonist KNT-127 produces distinct anxiolytic-like effects in rats without producing the adverse effects associated with benzodiazepines. Neuropharmacology, 67, 485-493. https://doi.org/10.1016/j.neuropharm.2012.11.025
Sandoval, I. V., Arredondo, J. J., Alcalde, J., Noriega, A. G., Vandekerckhove, J., Jimenez, M. A., & Rico, M. (1994). The residues Leu(Ile)475-Ile(Leu, Val, Ala)476, contained in the extended carboxyl cytoplasmic tail, are critical for targeting of the resident lysosomal membrane protein LIMP II to lysosomes. Journal of Biological Chemistry, 269, 6622-6631.
Sandoval, I. V., & Bakke, O. (1994). Targeting of membrane proteins to endosomes and lysosomes. Trends in Cell Biology, 4, 292-297.
Sandoval, I. V., Martínez-Arca, S., Valdueza, J., Palacios, S., & Holman, G. D. (2000). Distinct reading of different structural determinants modulates the dileucine-mediated transport steps of the lysosomal membrane protein LIMPII and the insulin-sensitive glucose transporter GLUT4. Journal of Biological Chemistry, 275, 39874-39885.
Sano, H., Eguez, L., Teruel, M. N., Fukuda, M., Chuang, T. D., Chavez, J. A., Lienhard, G. E., & McGraw, T. E. (2007). Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane. Cell Metabolism, 5, 293-303. https://doi.org/10.1016/j.cmet.2007.03.001
Sarajärvi, T., Tuusa, J. T., Haapasalo, A., Lackman, J. J., Sormunen, R., Helisalmi, S., Roehr, J. T., Parrado, A. R., Mäkinen, P., Bertram, L., & Soininen, H. (2011). Cysteine 27 variant of the δ-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking. Molecular and Cellular Biology, 31, 2326-2340.
Sawyer, G. W., Ehlert, F. J., & Shults, C. A. (2010). A conserved motif in the membrane proximal C-terminal tail of human muscarinic M1 acetylcholine receptors affects plasma membrane expression. Journal of Pharmacology and Experimental Therapeutics, 332, 76-86.
Schülein, R., Hermosilla, R., Oksche, A., Dehe, M., Wiesner, B., Krause, G., & Rosenthal, W. (1998). A dileucine sequence and an upstream glutamate residue in the intracellular carboxyl terminus of the vasopressin V2 receptor are essential for cell surface transport in COS.M6 cells. Molecular Pharmacology, 54, 525-535.
Seachrist, J. L., Laporte, S. A., Dale, L. B., Babwah, A. V., Caron, M. G., Anborgh, P. H., & Ferguson, S. S. (2002). Rab5 association with the angiotensin II type 1A receptor promotes Rab5 GTP binding and vesicular fusion. Journal of Biological Chemistry, 277, 679-685.
Sharma, R., Gulia, R., & Bhattacharyya, S. (2018). A critical role for sorting nexin 1 in the trafficking of metabotropic glutamate receptors. Journal of Neuroscience, 38, 8605-8620.
Shiwarski, D. J., Crilly, S. E., Dates, A., & Puthenveedu, M. A. (2019). Dual RXR motifs regulate nerve growth factor-mediated intracellular retention of the delta opioid receptor. Molecular Biology of the Cell, 30, 680-690.
Shiwarski, D. J., Darr, M., Telmer, C. A., Bruchez, M. P., & Puthenveedu, M. A. (2017). PI3K class II α regulates δ-opioid receptor export from the trans-Golgi network. Molecular Biology of the Cell, 28, 2202-2219.
Shiwarski, D. J., Tipton, A., Giraldo, M. D., Schmidt, B. F., Gold, M. S., Pradhan, A. A., & Puthenveedu, M. A. (2017). A PTEN-regulated checkpoint controls surface delivery of δ opioid receptors. Journal of Neuroscience, 37, 3741-3752.
Sieben, C., Mikosch, M., Brandizzi, F., & Homann, U. (2008). Interaction of the K+-channel KAT1 with the coat protein complex II coat component Sec24 depends on a diacidic endoplasmic reticulum export motif. Plant Journal, 56, 997-1006.
Simon, E. J., & Onoprishvili, I. (2010). The interaction between the mu opioid receptor and filamin A. Neurochemical Research, 35, 1859-1866.
Simonin, F., Karcher, P., Boeuf, J. J. M., Matifas, A., & Kieffer, B. L. (2004). Identification of a novel family of G protein-coupled receptor associated sorting proteins. Journal of Neurochemistry, 89, 766-775.
Skieterska, K., Rondou, P., & Van Craenenbroeck, K. (2017). Regulation of G protein-coupled receptors by ubiquitination. International Journal of Molecular Sciences, 18, 10-13.
Spahn, V., & Stein, C. (2017). Targeting delta opioid receptors for pain treatment: Drugs in phase I and II clinical development. Expert Opinion on Investigational Drugs, 26, 155-160.
Spampinato, S., Di Toro, R., Alessandri, M., & Murari, G. (2002). Agonist-induced internalization and desensitization of the human nociceptin receptor expressed in CHO cells. Cellular and Molecular Life Sciences, 59, 2172-2183.
St-Louis, É., Degrandmaison, J., Grastilleur, S., Génier, S., Blais, V., Lavoie, C., Parent, J. L., & Gendron, L. (2017). Involvement of the coatomer protein complex I in the intracellular traffic of the delta opioid receptor. Molecular and Cellular Neurosciences, 79, 53-63.
Stratinaki, M., Varidaki, A., Mitsi, V., Ghose, S., Magida, J., Dias, C., Russo, S. J., Vialou, V., Caldarone, B. J., Tamminga, C. A., & Nestler, E. J. (2013). Regulator of G protein signaling is a crucial modulator of antidepressant drug action in depression and neuropathic pain models. Proceedings of the National Academy of Sciences of the United States of America, 110, 8254-8259.
Sungkaworn, T., Jobin, M. L., Burnecki, K., Weron, A., Lohse, M. J., & Calebiro, D. (2017). Single-molecule imaging reveals receptor-G protein interactions at cell surface hot spots. Nature, 550, 543-547.
Tam, B. M., Xie, G., Oprian, D. D., & Moritz, O. L. (2006). Mislocalized rhodopsin does not require activation to cause retinal degeneration and neurite outgrowth in Xenopus laevis. Journal of Neuroscience, 26, 203-209.
Tanowitz, M., Hislop, J. N., & Von Zastrow, M. (2008). Alternative splicing determines the post-endocytic sorting fate of G-protein-coupled receptors. Journal of Biological Chemistry, 283, 35614-35621.
Tanowitz, M., & Von Zastrow, M. (2002). Ubiquitination-independent trafficking of G protein-coupled receptors to lysosomes. Journal of Biological Chemistry, 277, 50219-50222.
Tanowitz, M., & Von Zastrow, M. (2003). A novel endocytic recycling signal that distinguishes the membrane trafficking of naturally occurring opioid receptors. Journal of Biological Chemistry, 278, 45978-45986. https://doi.org/10.1074/jbc.M304504200
Tappe-Theodor, A., Agarwal, N., Katona, I., Rubino, T., Martini, L., Swiercz, J., Mackie, K., Monyer, H., Parolaro, D., Whistler, J., & Kuner, T. (2007). A molecular basis of analgesic tolerance to cannabinoids. Journal of Neuroscience, 27, 4165-4177.
Thompson, A. A., Liu, W., Chun, E., Katritch, V., Wu, H., Vardy, E., Huang, X. P., Trapella, C., Guerrini, R., Calo, G., & Roth, B. L. (2012). Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic. Nature, 485, 395-399.
Toll, L., Bruchas, M. R., Calo, G., Cox, B. M., & Zaveri, N. T. (2016). Nociceptin/orphanin FQ receptor structure, signaling, ligands, functions, and interactions with opioid systems. Pharmacological Reviews, 68, 419-457.
Trapaidze, N., Gomes, I., Bansinath, M., & Devi, L. A. (2000). Recycling and resensitization of delta opioid receptors. DNA and Cell Biology, 19, 195-204.
Tsao, P. I., & Von Zastrow, M. (2000). Type-specific sorting of G protein-coupled receptors after endocytosis. Journal of Biological Chemistry, 275, 11130-11140.
Tuusa, J. T., Leskelä, T. T., & Petäjä-Repo, U. E. (2010). Human δ opioid receptor biogenesis is regulated via interactions with SERCA2b and calnexin. FEBS Journal, 277, 2815-2829.
Walther, C., Lotze, J., Beck-Sickinger, A. G., & Mörl, K. (2012). The anterograde transport of the human neuropeptide Y2 receptor is regulated by a subtype specific mechanism mediated by the C-terminus. Neuropeptides, 46, 335-343. https://doi.org/10.1016/j.npep.2012.08.011
Wang, G., Wei, Z., & Wu, G. (2018). Role of Rab GTPases in the export trafficking of G protein-coupled receptors. Small GTPases, 9, 130-135. https://doi.org/10.1080/21541248.2016.1277000
Wang, H. L., Kuo, Y. L., Hsu, C. Y., Huang, P. C., Li, A. H., Chou, A. H., Yeh, T. H., & Chen, Y. L. (2006). Two C-terminal amino acids, Ser334 and Ser335, are required for homologous desensitization and agonist-induced phosphorylation of opioid receptor-like 1 receptors. Cell Signaling, 18, 670-678.
Wang, H., & Pickel, V. M. (2001). Preferential cytoplasmic localization of delta-opioid receptors in rat striatal patches: Comparison with plasmalemmal mu-opioid receptors. Journal of Neuroscience, 21, 3242-3250.
Wang, T., Liu, N. S., Seet, L. F., & Hong, W. (2010). The emerging role of VHS domain-containing Tom1, Tom1L1 and Tom1L2 in membrane trafficking. Traffic, 11, 1119-1128. https://doi.org/10.1111/j.1600-0854.2010.01098.x
Wang, W., Loh, H. H., & Law, P. Y. (2003). The intracellular trafficking of opioid receptors directed by carboxyl tail and a di-leucine motif in Neuro2A cells. Journal of Biological Chemistry, 278, 36848-36858.
Wang, Y., Zhou, Y., Szabo, K., Haft, C. R., & Trejo, J. A. (2002). Down-regulation of protease-activated receptor-1 is regulated by sorting nexin 1. Molecular Biology of the Cell, 13, 1965-1976.
Watson, N., Linder, M. E., Druey, K. M., Kehrl, J. H., & Blumer, K. J. (1996). RGS family members: GTPase-activating proteins for heterotrimeric G-protein α-subunits. Nature, 383, 172-175.
Weinman, E. J., Steplock, D., Wang, Y., & Shenolikar, S. (1995). Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na+-H+ exchanger. Journal of Clinical Investigation, 95, 2143-2149.
Wheway, G., Schmidts, M., Mans, D. A., Szymanska, K., Nguyen, T. M., Racher, H., Phelps, I. G., Toedt, G., Kennedy, J., Wunderlich, K. A., & Sorusch, N. (2015). An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes. Nature Cell Biology, 17, 1074-1087.
Whistler, J. L., Enquist, J., Marley, A., Fong, J., Gladher, F., Tsuruda, P., Murray, S. R., & Von Zastrow, M. (2002). Modulation of postendocytic sorting of G protein-coupled receptors. Science, 297, 615-620.
Wu, D. F., Koch, T., Liang, Y. J., Stumm, R., Schulz, S., Schröder, H., & Höllt, V. (2007). Membrane glycoprotein M6a interacts with the micro-opioid receptor and facilitates receptor endocytosis and recycling. Journal of Biological Chemistry, 282, 22239-22247.
Wyse, B. D., Prior, I. A., Qian, H., Morrow, I. C., Nixon, S., Muncke, C., Kurzchalia, T. V., Thomas, W. G., Parton, R. G., & Hancock, J. F. (2003). Caveolin interacts with the angiotensin II type I receptor during exocytic transport but not at the plasma membrane. Journal of Biological Chemistry, 278, 23738-23746.
Xiang, B., Yu, G. H., Guo, J., Chen, L., Hu, W., Pei, G., & Ma, L. (2001). Heterologous activation of protein kinase C stimulates phosphorylation of δ-opioid receptor at serine 344, resulting in β-arrestin- and clathrin-mediated receptor internalization. Journal of Biological Chemistry, 276, 4709-4716.
Xie, W. Y., He, Y., Yang, Y. R., Li, Y. F., Kang, K., Xing, B. M., & Wang, Y. (2009). Disruption of Cdk5-associated phosphorylation of residue threonine-161 of the delta-opioid receptor: Impaired receptor function and attenuated morphine antinociceptive tolerance. Journal of Neuroscience, 29, 3551-3564.
Xu, W., Yoon, S. I., Huang, P., Wang, Y., Chen, C., Chong, P. L., & Liu-Chen, L. Y. (2006). Localization of the κ opioid receptor in lipid rafts. Journal of Pharmacology and Experimental Therapeutics, 317, 1295-1306.
Xu, X. J., Hao, J. X., & Wiesenfeld-Hallin, Z. (1996). Nociceptin or antinociceptin: Potent spinal antinociceptive effect of orphanin FQ/nociceptin in the rat. NeuroReport, 7, 2092-2094.
Yamamoto, T., Nozaki-Taguchi, N., & Kimura, S. (1997). Analgesic effect of intrathecally administered nociceptin, an opioid receptor-like receptor agonist, in the rat formalin test. Neuroscience, 81, 249-254.
Yong, R. J., Mullins, P. M., & Bhattacharyya, N. (2021). Prevalence of chronic pain among adults in the United States. Pain, 1-5.
Yuan, L., Barbash, S., Kongsamut, S., Eishingdrelo, A., Sakmar, T. P., & Eishingdrelo, H. (2019). 14-3-3 signal adaptor and scaffold proteins mediate GPCR trafficking. Scientific Reports, 9, 11156.
Zhang, M., & Wu, G. (2019). Mechanisms of the anterograde trafficking of GPCRs: Regulation of AT1R transport by interacting proteins and motifs. Traffic, 20, 110-120. https://doi.org/10.1111/tra.12624
Zhang, N. R., Planer, W., Siuda, E. R., Zhao, H. C., Stickler, L., Chang, S. D., Baird, M. A., Cao, Y. Q., & Bruchas, M. R. (2012). Serine 363 is required for nociceptin/orphanin FQ opioid receptor (NOPR) desensitization, internalization, and arrestin signaling. Journal of Biological Chemistry, 287, 42019-42030.
Zhang, S., Tong, Y., Tian, M., Dehaven, R. N., Cortesburgos, L., Mansson, E., Simonin, F., Kieffer, B., & Yu, L. (1998). Dynorphin A as a potential endogenous ligand for four members of the opioid receptor gene family. Journal of Pharmacology and Experimental Therapeutics, 286, 136-141.
Zhang, X., Dong, C., Wu, Q. J., Balch, W. E., & Wu, G. (2011). Diacidic motifs in the membrane-distal C termini modulate the transport of angiotensin II receptors from the endoplasmic reticulum to the cell surface. Journal of Biological Chemistry, 286, 20525-20535.
Zhang, X., Wang, H., Duvernay, M. T., Zhu, S., & Wu, G. (2013). The angiotensin II type 1 receptor C-terminal Lys residues interact with tubulin and modulate receptor export trafficking. PLoS ONE, 8, 1-9. https://doi.org/10.1371/journal.pone.0057805
Zheng, H., Pearsall, E. A., Hurst, D. P., Zhang, Y., Chu, J., Zhou, Y., Reggio, P. H., Loh, H. H., & Law, P. Y. (2012). Palmitoylation and membrane cholesterol stabilize μ-opioid receptor homodimerization and G protein coupling. BMC Cell Biology, 13, 1-18.
Zheng, N., & Shabek, N. (2017). Ubiquitin ligases: Structure, function, and regulation. Annual Review of Biochemistry, 86, 129-157.
Zuzarte, M., Rinné, S., Schlichthörl, G., Schubert, A., Daut, J., & Preisig-Müller, R. (2007). A diacidic sequence motif enhances the surface expression of the potassium channel TASK-3. Traffic, 8, 1093-1100. https://doi.org/10.1111/j.1600-0854.2007.00593.x