Biaxial mechanics of thermally denaturing skin - Part 1: Experiments.
Birefringence
Collagen
Histology
Isometric
Isotonic
Mouse
Planar biaxial
Shrinkage
Two photon microscopy
Journal
Acta biomaterialia
ISSN: 1878-7568
Titre abrégé: Acta Biomater
Pays: England
ID NLM: 101233144
Informations de publication
Date de publication:
01 03 2022
01 03 2022
Historique:
received:
04
06
2021
revised:
14
09
2021
accepted:
17
09
2021
pubmed:
25
9
2021
medline:
5
3
2022
entrez:
24
9
2021
Statut:
ppublish
Résumé
The mechanics of collagenous soft tissues, such as skin, are sensitive to heat. Thus, quantifying and modeling thermo-mechanical coupling of skin is critical to our understanding of skin's physiology, pathophysiology, and its treatment. However, key gaps persist in our knowledge about skin's coupled thermo-mechanics. Among them, we haven't quantified the role of skin's microstructural organization in its response to superphysiological loading. To fill this gap, we conducted a comprehensive set of experiments in which we combined biaxial mechanical testing with histology and two-photon imaging under liquid heat treatment at temperatures ranging from 37
Identifiants
pubmed: 34560301
pii: S1742-7061(21)00621-8
doi: 10.1016/j.actbio.2021.09.033
pii:
doi:
Substances chimiques
Collagen
9007-34-5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
412-420Subventions
Organisme : NHLBI NIH HHS
ID : F31 HL145976
Pays : United States
Informations de copyright
Copyright © 2021 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.