Impact of vaginal distention on cell senescence in an animal model of pelvic organ prolapse.
Animals
Biomarkers
/ metabolism
Cellular Senescence
Cyclin-Dependent Kinase Inhibitor p16
/ metabolism
Disease Models, Animal
Extracellular Matrix Proteins
/ deficiency
Female
Mice, Knockout
Pelvic Organ Prolapse
/ pathology
Phenotype
Recombinant Proteins
/ metabolism
Stromal Cells
/ metabolism
Vagina
/ pathology
beta-Galactosidase
/ metabolism
Animal model
Cell senescence
Childbirth trauma
Pelvic organ prolapse
Pregnancy
Journal
Tissue & cell
ISSN: 1532-3072
Titre abrégé: Tissue Cell
Pays: Scotland
ID NLM: 0214745
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
08
07
2021
accepted:
15
09
2021
pubmed:
25
9
2021
medline:
3
3
2022
entrez:
24
9
2021
Statut:
ppublish
Résumé
Cellular senescence, associated with aging, leads to impaired tissue regeneration. We hypothesize that vaginal injury initiates cell senescence, further propagated during aging resulting in pelvic organ prolapse (POP). Our objective was to employ a mouse model of POP (Fibulin-5 knockout mice, Fbln5 6wk old females [wild-type (WT), n = 81; Fbln5 WT distended mice showed decreased p53 (p = 0.0230) and γ-H2Ax (p = 0.0008) in vaginal stromal cells at 1wk compared to controls. In WT mice, SA-β-Gal activity increased 1wk after distention (p = 0.05). In Fbln5 Vaginal distention downregulates p53 and γ-H2Ax in WT mice, thereby promoting cell proliferation 1wk after injury. This was absent among Fbln5
Identifiants
pubmed: 34560406
pii: S0040-8166(21)00168-3
doi: 10.1016/j.tice.2021.101652
pii:
doi:
Substances chimiques
Biomarkers
0
Cyclin-Dependent Kinase Inhibitor p16
0
Extracellular Matrix Proteins
0
Fbln5 protein, mouse
0
Recombinant Proteins
0
beta-Galactosidase
EC 3.2.1.23
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
101652Informations de copyright
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