Insulin signaling alters antioxidant capacity in the diabetic heart.

Animals Antioxidants Diabetes Mellitus, Experimental / drug therapy Insulin Mice Oxidative Stress Phosphatidylinositol 3-Kinases
Cardiomyocytes Diabetes EPR Heart Insulin Thioredoxin

Journal

Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639

Informations de publication

Date de publication:
11 2021
Historique:
received: 26 08 2021
revised: 14 09 2021
accepted: 16 09 2021
pubmed: 25 9 2021
medline: 1 12 2021
entrez: 24 9 2021
Statut: ppublish

Résumé

Diabetic cardiomyopathy is associated with an increase in oxidative stress. However, antioxidant therapy has shown a limited capacity to mitigate disease pathology. The molecular mechanisms responsible for the modulation of reactive oxygen species (ROS) production and clearance must be better defined. The objective of this study was to determine how insulin affects superoxide radical (O

Identifiants

DOI: 10.1016/j.redox.2021.102140 PMID: 34560411 PMC: PMC8473541
pubmed: 34560411
pii: S2213-2317(21)00299-8
doi: 10.1016/j.redox.2021.102140
pmc: PMC8473541
pii:
doi:

Substances chimiques

Antioxidants 0
Insulin 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

102140

Subventions

Organisme : NIGMS NIH HHS
ID : P20 GM103447
Pays : United States
Organisme : NIGMS NIH HHS
ID : R24 GM137786
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL125625
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG050911
Pays : United States

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Auteurs

Satoshi Matsuzaki (S)

Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK, 73104, USA.

Craig Eyster (C)

Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK, 73104, USA.

Maria F Newhardt (MF)

Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK, 73104, USA; Department of Biochemistry and Molecular Biology, University of Oklahoma Health Science Center, Oklahoma City, OK, 73104, USA.

Jennifer R Giorgione (JR)

Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK, 73104, USA.

Caroline Kinter (C)

Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK, 73104, USA.

Zachary T Young (ZT)

Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK, 73104, USA.

Michael Kinter (M)

Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK, 73104, USA.

Kenneth M Humphries (KM)

Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK, 73104, USA; Department of Biochemistry and Molecular Biology, University of Oklahoma Health Science Center, Oklahoma City, OK, 73104, USA. Electronic address: kenneth-humphries@omrf.org.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Insulin signaling alters antioxidant capacity...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Insulin signaling alters antioxidant capacity...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Diabète expérimental › Insulin signaling alters antioxidant capacity...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › Insulin signaling alters antioxidant capacity...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Insulin signaling alters antioxidant capacity...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Insulin signaling alters antioxidant capacity...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphatidylinositol 3-kinases › Insulin signaling alters antioxidant capacity...