Ulmoidol, an unusual nortriterpenoid from Eucommia ulmoides Oliv. Leaves prevents neuroinflammation by targeting the PU.1 transcriptional signaling pathway.
Dose-Response Relationship, Drug
Eucommiaceae
/ chemistry
Humans
Molecular Structure
Neuroinflammatory Diseases
/ drug therapy
Plant Leaves
/ chemistry
Proto-Oncogene Proteins
/ antagonists & inhibitors
Signal Transduction
/ drug effects
Structure-Activity Relationship
Trans-Activators
/ antagonists & inhibitors
Triterpenes
/ isolation & purification
Eucommia ulmoides
Neuroinflammation
Oliver
ursane triterpenoid
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
13
05
2021
revised:
24
08
2021
accepted:
07
09
2021
pubmed:
25
9
2021
medline:
5
1
2022
entrez:
24
9
2021
Statut:
ppublish
Résumé
Chronic neuroinflammation is closely associated with the development of neurodegenerative diseases, including Alzheimer's disease (AD). In the current study, 13 anti-neuroinflammatory compounds were isolated from Eucommia ulmoides Oliv. leaves. Among these compounds, trans-sinapaldehyde (6), 3',4',5,7-tetrahydroxy-3-methylflavone (7), and amarusine A (13) were isolated from E. ulmoides leaves for the first time. The ursane-type C
Identifiants
pubmed: 34560559
pii: S0045-2068(21)00722-7
doi: 10.1016/j.bioorg.2021.105345
pii:
doi:
Substances chimiques
Proto-Oncogene Proteins
0
Trans-Activators
0
Triterpenes
0
proto-oncogene protein Spi-1
0
ulmoidol
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105345Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.