Association of sensory phenotype with quality of life, functionality, and emotional well-being in patients suffering from neuropathic pain.
Journal
Pain
ISSN: 1872-6623
Titre abrégé: Pain
Pays: United States
ID NLM: 7508686
Informations de publication
Date de publication:
01 07 2022
01 07 2022
Historique:
received:
30
04
2021
accepted:
15
09
2021
pubmed:
26
9
2021
medline:
22
6
2022
entrez:
25
9
2021
Statut:
ppublish
Résumé
Neuropathic pain highly affects quality of life, well-being, and function. It has recently been shown based on cluster analysis studies that most patients with neuropathic pain may be categorized into 1 of 3 sensory phenotypes: sensory loss, mechanical hyperalgesia, and thermal hyperalgesia. If these phenotypes reflect underlying pathophysiological mechanisms, they may be more relevant for patient management than underlying neurological diagnosis or pain intensity. The aim of this study was thus to examine the impact of these sensory phenotypes on mental health, functionality, and quality of life. Data of 433 patients from the IMI/EuroPain network database were analyzed, and results of HADS-D/A, Pain Catastrophizing Scale, Euro Quality of Life 5D/-VAS, Brief Pain Inventory, and Graded Chronic Pain Scale between the sensory phenotypes were compared using multiple regression analysis. There was no difference in chronic pain grade, pain intensity, depression, or anxiety scores between phenotypes. Pain interference (Brief Pain Inventory) was higher (P = 0.002); self-reported health state lower (Euro Quality of Life 5D VAS, P = 0.02); and problems regarding mobility (P = 0.008), usual activities (P = 0.004), and self-care (P = 0.039) more prominent (EQ5-D) in the sensory loss compared with the thermal hyperalgesia phenotype. Patients with sensory loss also showed higher pain catastrophizing scores (P = 0.006 and 0.022, respectively) compared with the 2 other groups. Sensory phenotype is associated with the impact of neuropathic pain conditions on well-being, daily functionality, and quality of life but is less associated with pain intensity. These results suggest that the somatosensory phenotype should be considered for personalized pain management.
Identifiants
pubmed: 34561391
doi: 10.1097/j.pain.0000000000002501
pii: 00006396-202207000-00016
pmc: PMC9199110
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1378-1387Informations de copyright
Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association for the Study of Pain.
Références
Anson E, Bigelow RT, Swenor B, Deshpande N, Studenski S, Jeka JJ, Agrawal Y. Loss of peripheral sensory function explains much of the increase in postural sway in healthy older adults. Front Aging Neurosci 2017;9:202.
Attal N, Lanteri-Minet M, Laurent B, Fermanian J, Bouhassira D. The specific disease burden of neuropathic pain: results of a French nationwide survey. PAIN 2011;152:2836–43.
Backonja MM, Stacey B. Neuropathic pain symptoms relative to overall pain rating. J Pain 2004;5:491–7.
Benbow SJ, Wallymahmed ME, Macfarlane IA. Diabetic peripheral neuropathy and quality of life. QJM 1998;91:733–7.
Bjelland I, Dahl AA, Haug TT, Neckelmann D. The validity of the hospital anxiety and depression scale. J Psychosom Res 2002;52:69–77.
Brooks R, De Charro F. EuroQol: the current state of play. Health Policy 1996;37:53–72.
Burke D, Lennon O, Fullen BM. Quality of life after spinal cord injury: the impact of pain. Eur J Pain 2018;22:1662–72.
Cimino Brown D. Brief Pain Inventory User Guide. 2017. Available at: www.CanineBPI.com .
Cleeland C. The brief pain inventory user guide. Br Pain Invent 2009:3–4. Available at: http://www.mdanderson.org/education-and-research/departments-programs-and-labs/departments-and-divisions/symptom-research/symptom-assessment-tools/BPI_UserGuide.pdf .
Craner JR, Sperry JA, Evans MM. The relationship between pain catastrophizing and outcomes of a 3-week comprehensive pain rehabilitation program. Pain Med 2016;17:2026–35.
Cruz-Almeida Y, Alameda G, Widerström-Noga EG. Differentiation between pain-related interference and interference caused by the functional impairments of spinal cord injury. Spinal Cord 2009;47:390–6.
Deshpande N, Simonsick E, Metter EJ, Ko S, Ferrucci L, Studenski S. Ankle proprioceptive acuity is associated with objective as well as self-report measures of balance, mobility, and physical function. Age (Dordr) 2016;38:53.
Forstenpointner J, Rehm S, Gierthmühlen J, Baron R. Stratification of neuropathic pain patients: the road to mechanism-based therapy? Curr Opin Anaesthesiol 2018;31:562–8.
Freynhagen R, Parada HA, Calderon-Ospina CA, Chen J, Rakhmawati Emril D, Fernández-Villacorta FJ, Franco H, Ho KY, Lara-Solares A, Li CCF, Mimenza Alvarado A, Nimmaanrat S, Dolma Santos M, Ciampi de Andrade D. Current understanding of the mixed pain concept: a brief narrative review. Curr Med Res Opin 2019;35:1011–18.
Furrer A, Michel G, Terrill AL, Jensen MP, Müller R. Modeling subjective well-being in individuals with chronic pain and a physical disability: the role of pain control and pain catastrophizing. Disabil Rehabil 2019;41:498–507.
Galer BS, Gianas A, Jensen MP. Painful diabetic polyneuropathy: epidemiology, pain description, and quality of life. Diabetes Res Clin Pract 2000;47:123–8.
Geelen CC, Kindermans HP, van den Bergh JP, Verbunt JA. Perceived physical activity decline as a mediator in the relationship between pain catastrophizing, disability, and quality of life in patients with painful diabetic neuropathy. Pain Pract 2017;17:320–8.
Gierthmühlen J, Baron R. Neuropathic pain. Semin Neurol 2016;36:462–8.
Gierthmühlen J, Greinacher J, Höper J, Oberlojer V, Lankes M, Traulsen F, Hüllemann P, Borzikowsky C, Reimer M, Baron R. Sensory symptoms in low back pain—how do they matter? Curr Med Res Opin 2018;34:657–67.
Gore M, Brandenburg NA, Dukes E, Hoffman DL, Tai KS, Stacey B. Pain severity in diabetic peripheral neuropathy is associated with patient functioning, symptom levels of anxiety and depression, and sleep. J Pain Symptom Manage 2005;30:374–85.
Gutierrez DD, Thompson L, Kemp B, Mulroy SJ, Winstein CJ, Gordon J, Brown DA, Knutson L, Fowler E, DeMuth S, Kulig K, Sullivan K. The relationship of shoulder pain intensity to quality of life, physical activity, and community participation in persons with paraplegia. J Spinal Cord Med 2007;30:251–5.
Haroun OMO, Vollert J, Lockwood DN, Bennett DLH, Pai VV, Shetty V, Wakade AV, Khodke AS, Schilder A, Pfau D, Enax-Krumova EK, Maier C, Treede R-D, Rice ASC. Clinical characteristics of neuropathic pain in leprosy and associated somatosensory profiles. PAIN Rep 2019;4:e743.
IsHak WW, Wen RY, Naghdechi L, Vanle B, Dang J, Knosp M, Dascal J, Marcia L, Gohar Y, Eskander L, Yadegar J, Hanna S, Sadek A, Aguilar-Hernandez L, Danovitch I, Louy C. Pain and depression: a systematic review. Harv Rev Psychiatry 2018;26:352–63.
Von Korff M, Ormel J, Keefe FJ, Dworkin SF. Grading the severity of chronic pain. PAIN 1992;50:133–49.
Kröner-Herwig B, Jäkle C, Frettlöh J, Peters K, Seemann H, Franz C, Basler HD. Predicting subjective disability in chronic pain patients. Int J Behav Med 1996;3:30–41.
Kwon HJ, Kim JS, Kim YJ, Kwon SJ, Yu JN. Sensory impairment and health-related quality of life. Iran J Public Health 2015;44:772–82.
Macone A, Otis J. Neuropathic pain. Semin Neurol 2018;38:644–53.
Magerl W, Krumova EK, Baron R, Tölle T, Treede RD, Maier C. Reference data for quantitative sensory testing (QST): refined stratification for age and a novel method for statistical comparison of group data. PAIN 2010;151:598–605.
McCallum LM, Damms NA, Sarrigiannis PG, Zis P. Anxiety and depression in patients with suspected carpal tunnel syndrome—a case controlled study. Brain Behav 2019;9:1–5.
Müller R, Landmann G, Béchir M, Hinrichs T, Arnet U, Jordan X, Brinkhof MWG. Chronic pain, depression and quality of life in individuals with spinal cord injury: mediating role of participation. J Rehabil Med 2017;49:489–96.
Naranjo C, Del Reguero L, Moratalla G, Hercberg M, Valenzuela M, Failde I. Anxiety, depression and sleep disorders in patients with diabetic neuropathic pain: a systematic review. Expert Rev Neurother 2019;19:1201–9.
Pfau DB, Krumova EK, Treede RD, Baron R, Toelle T, Birklein F, Eich W, Geber C, Gerhardt A, Weiss T, Magerl W, Maier C. Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): reference data for the trunk and application in patients with chronic postherpetic neuralgia. PAIN 2014;155:1002–15.
Phillips TJC, Brown M, Ramirez JD, Perkins J, Woldeamanuel YW, De Williams ACC, Orengo C, Bennett DLH, Bodi I, Cox S, Maier C, Krumova EK, Rice ASC. Sensory, psychological, and metabolic dysfunction in HIV-associated peripheral neuropathy: a cross-sectional deep profiling study. PAIN 2014;155:1846–60.
Racine M, Moulin DE, Nielson WR, Morley-Forster PK, Lynch M, Clark AJ, Stitt L, Gordon A, Nathan H, Smyth C, Ware MA, Jensen MP. The reciprocal associations between catastrophizing and pain outcomes in patients being treated for neuropathic pain: a cross-lagged panel analysis study. PAIN 2016;157:1946–53.
Van Reenen M, Oppe M, Boye K, Herdman M, Kennedy-Martin M, Kenndy-Martin T, Slaap B. EuroQol research foundation. EQ-5D-3L user guide. EuroQol Res Found 2018:1–33. Available at: https://euroqol.org/publications/user-guides .
Rolke R, Baron R, Maier C, Tölle TR, Treede RD, Beyer A, Binder A, Birbaumer N, Birklein F, Bötefür IC, Braune S, Flor H, Huge V, Klug R, Landwehrmeyer GB, Magerl W, Maihöfner C, Rolko C, Schaub C, Scherens A, Sprenger T, Valet M, Wasserka B. Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values. PAIN 2006;123:231–43.
Sadosky A, Schaefer C, Mann R, Bergstrom F, Baik R, Parsons B, Nalamachu S, Nieshoff E, Stacey BR, Anschel A, Tuchman M. Burden of illness associated with painful diabetic peripheral neuropathy among adults seeking treatment in the US: results from a retrospective chart review and cross-sectional survey. Diabetes Metab Syndr Obes Targets Ther 2013;6:79–92.
Sullivan M, Bishop S, Pivik J. The pain catastrophizing scale: user Manual. Psychol Assess 1995;7:524–32.
Sullivan MJL, Lynch ME, Clark AJ. Dimensions of catastrophic thinking associated with pain experience and disability in patients with neuropathic pain conditions. PAIN 2005;113:310–15.
Sullivan MJL, Thorn B, Haythornthwaite JA, Keefe F, Martin M, Bradley LA, Lefebvre JC. Theoretical perspectives on the relation between catastrophizing and pain. Clin J Pain 2001;17:52–64.
Themistocleous AC, Ramirez JD, Shillo PR, Lees JG, Selvarajah D, Orengo C, Tesfaye S, Rice ASC, Bennett DLH. The Pain in Neuropathy Study (PiNS): a cross-sectional observational study determining the somatosensory phenotype of painful and painless diabetic neuropathy. PAIN 2016;157:1132–45.
Treede RD, Rief W, Barke A, Aziz Q, Bennett MI, Benoliel R, Cohen M, Evers S, Finnerup NB, First MB, Giamberardino MA, Kaasa S, Kosek E, Lavand'homme P, Nicholas M, Perrot S, Scholz J, Schug S, Smith BH, Svensson P, Vlaeyen JWS, Wang SJ. A classification of chronic pain for ICD-11. PAIN 2015;156:1003–7.
Vollert J, Attal N, Baron R, Freynhagen R, Haanpää M, Hansson P, Jensen TS, Rice ASC, Segerdahl M, Serra J, Sindrup SH, Tölle TR, Treede RD, Maier C. Quantitative sensory testing using DFNS protocol in Europe: an evaluation of heterogeneity across multiple centers in patients with peripheral neuropathic pain and healthy subjects. PAIN 2016;157:750–8.
Vollert J, Maier C, Attal N, Bennett DLH, Bouhassira D, Enax-Krumova EK, Finnerup NB, Freynhagen R, Gierthmühlen J, Haanpää M, Hansson P, Hüllemann P, Jensen TS, Magerl W, Ramirez JD, Rice ASC, Schuh-Hofer S, Segerdahl M, Serra J, Shillo PR, Sindrup S, Tesfaye S, Themistocleous AC, Tölle TR, Treede R-D, Baron R. Stratifying patients with peripheral neuropathic pain based on sensory profiles. PAIN 2017;158:1446–55.
Vollert J, Mainka T, Baron R, Enax-Krumova EK, Hüllemann P, Maier C, Pfau DB, Tölle T, Treede RD. Quality assurance for Quantitative Sensory Testing laboratories: development and validation of an automated evaluation tool for the analysis of declared healthy samples. PAIN 2015;156:2423–30.
Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand 1983;67:361–70.