New insight into the catalytic -dependent and -independent roles of METTL3 in sustaining aberrant translation in chronic myeloid leukemia.
Adenosine
/ analogs & derivatives
Catalysis
Cell Line, Tumor
Cell Nucleus
/ metabolism
Cell Proliferation
Cell Survival
Drug Resistance, Neoplasm
/ drug effects
Gene Knockdown Techniques
Humans
Imatinib Mesylate
/ pharmacology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/ drug therapy
Methyltransferases
/ metabolism
Models, Biological
Protein Biosynthesis
Proto-Oncogene Proteins c-myc
/ metabolism
RNA, Messenger
/ genetics
RNA-Binding Proteins
/ genetics
Up-Regulation
Journal
Cell death & disease
ISSN: 2041-4889
Titre abrégé: Cell Death Dis
Pays: England
ID NLM: 101524092
Informations de publication
Date de publication:
24 09 2021
24 09 2021
Historique:
received:
15
04
2021
accepted:
16
09
2021
revised:
03
09
2021
entrez:
25
9
2021
pubmed:
26
9
2021
medline:
4
2
2022
Statut:
epublish
Résumé
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by the presence of tyrosine kinase BCR-ABL1 fusion protein, which deregulate transcription and mRNA translation. Tyrosine kinase inhibitors (TKIs) are the first-choice treatment. However, resistance to TKIs remains a challenge to cure CML patients. Here, we reveal that the m
Identifiants
pubmed: 34561421
doi: 10.1038/s41419-021-04169-7
pii: 10.1038/s41419-021-04169-7
pmc: PMC8463696
doi:
Substances chimiques
MYC protein, human
0
PES1 protein, human
0
Proto-Oncogene Proteins c-myc
0
RNA, Messenger
0
RNA-Binding Proteins
0
Imatinib Mesylate
8A1O1M485B
N-methyladenosine
CLE6G00625
METTL14 protein, human
EC 2.1.1.-
Methyltransferases
EC 2.1.1.-
METTL3 protein, human
EC 2.1.1.62
Adenosine
K72T3FS567
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
870Subventions
Organisme : Associazione Italiana per la Ricerca sul Cancro (Italian Association for Cancer Research)
ID : 21267
Organisme : Associazione Italiana per la Ricerca sul Cancro (Italian Association for Cancer Research)
ID : 21406
Organisme : Sapienza Università di Roma (Sapienza University of Rome)
ID : RM11916B4ADE223F
Informations de copyright
© 2021. The Author(s).
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