The atypical Rho GTPase Rnd2 is critical for dentate granule neuron development and anxiety-like behavior during adult but not neonatal neurogenesis.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
29
07
2021
accepted:
08
09
2021
revised:
06
09
2021
pubmed:
26
9
2021
medline:
15
3
2022
entrez:
25
9
2021
Statut:
ppublish
Résumé
Despite the central role of Rho GTPases in neuronal development, their functions in adult hippocampal neurogenesis remain poorly explored. Here, by using a retrovirus-based loss-of-function approach in vivo, we show that the atypical Rho GTPase Rnd2 is crucial for survival, positioning, somatodendritic morphogenesis, and functional maturation of adult-born dentate granule neurons. Interestingly, most of these functions are specific to granule neurons generated during adulthood since the deletion of Rnd2 in neonatally-born granule neurons only affects dendritogenesis. In addition, suppression of Rnd2 in adult-born dentate granule neurons increases anxiety-like behavior whereas its deletion in pups has no such effect, a finding supporting the adult neurogenesis hypothesis of anxiety disorders. Thus, our results are in line with the view that adult neurogenesis is not a simple continuation of earlier processes from development, and establish a causal relationship between Rnd2 expression and anxiety.
Identifiants
pubmed: 34561615
doi: 10.1038/s41380-021-01301-z
pii: 10.1038/s41380-021-01301-z
pmc: PMC8872985
mid: EMS134725
doi:
Substances chimiques
Rnd2 protein, mouse
EC 3.6.1.-
rho GTP-Binding Proteins
EC 3.6.5.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7280-7295Subventions
Organisme : Wellcome Trust
ID : 106187
Pays : United Kingdom
Organisme : Wellcome Trust
ID : FC001089
Pays : United Kingdom
Organisme : Medical Research Council
ID : FC001089
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Cancer Research UK
ID : FC001089
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 086947/Z/08/Z
Pays : United Kingdom
Informations de copyright
© 2021. The Author(s).
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