Polyploidy in development and tumor models in Drosophila.
Cancer
Development
Drosophila
Endocycle
Endoreplication
Polyploidy
Journal
Seminars in cancer biology
ISSN: 1096-3650
Titre abrégé: Semin Cancer Biol
Pays: England
ID NLM: 9010218
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
18
04
2021
revised:
03
09
2021
accepted:
18
09
2021
pubmed:
26
9
2021
medline:
14
4
2022
entrez:
25
9
2021
Statut:
ppublish
Résumé
Polyploidy, a cell status defined as more than two sets of genomic DNA, is a conserved strategy across species that can increase cell size and biosynthetic production, but the functional aspects of polyploidy are nuanced and vary across cell types. Throughout Drosophila developmental stages (embryo, larva, pupa and adult), polyploid cells are present in numerous organs and help orchestrate development while contributing to normal growth, well-being and homeostasis of the organism. Conversely, increasing evidence has shown that polyploid cells are prevalent in Drosophila tumors and play important roles in tumor growth and invasiveness. Here, we summarize the genes and pathways involved in polyploidy during normal and tumorigenic development, the mechanisms underlying polyploidization, and the functional aspects of polyploidy in development, homeostasis and tumorigenesis in the Drosophila model.
Identifiants
pubmed: 34562587
pii: S1044-579X(21)00245-5
doi: 10.1016/j.semcancer.2021.09.011
pmc: PMC9239401
mid: NIHMS1743550
pii:
doi:
Substances chimiques
DNA
9007-49-2
Types de publication
Journal Article
Review
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
106-118Subventions
Organisme : NCI NIH HHS
ID : R01 CA224381
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA227789
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM072562
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
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