Gut microbiome in people living with HIV is associated with impaired thiamine and folate syntheses.
Folate
HIV
HIV comorbidities
Microbiome
Thiamine
Journal
Microbial pathogenesis
ISSN: 1096-1208
Titre abrégé: Microb Pathog
Pays: England
ID NLM: 8606191
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
13
11
2020
revised:
11
08
2021
accepted:
22
09
2021
pubmed:
27
9
2021
medline:
21
10
2021
entrez:
26
9
2021
Statut:
ppublish
Résumé
People living with HIV have a high incidence of cardiovascular and neurological diseases as comorbid disorders that are commonly linked to inflammation. While microbial translocation can augment inflammation during HIV infection, functional microbiome shifts that may increase pro-inflammatory responses have not been fully characterized. In addition, defining HIV-induced microbiome changes has been complicated by high variability among individuals. Here we conducted functional annotation of previously-published 16S ribosomal RNA gene sequences of 305 HIV positive and 249 negative individuals, with adjustment for geographic region, sex, sexual behavior, and age. Metagenome profiles were inferred from these individuals' 16S data. HIV infection was associated with impaired microbial vitamin B synthesis; around half of the gene families in thiamine and folate biosynthesis pathways were significantly less abundant in the HIV positive group than the negative control. These results are consistent with the high prevalence of thiamine and folate deficiencies in HIV infections. These HIV-induced microbiota shifts have the potential to influence cardiovascular and neurocognitive diseases, given the documented associations between B-vitamin deficiencies, inflammation, and these diseases. We also observed that most essential amino acid biosynthesis pathways were downregulated in the microbiome of HIV-infected individuals. Microbial vitamin B and amino acid synthesis pathways were not significantly recovered by antiretroviral treatment when we compared 262 ART positive and 184 ART negative individuals. Our meta-analysis provides a new outlook for understanding vitamin B and amino acid deficiencies in HIV patients, suggesting that interventions for reversing HIV-induced microbiome shifts may aid in lessening the burdens of HIV comorbidities.
Identifiants
pubmed: 34563611
pii: S0882-4010(21)00483-6
doi: 10.1016/j.micpath.2021.105209
pmc: PMC8530907
mid: NIHMS1743545
pii:
doi:
Substances chimiques
RNA, Ribosomal, 16S
0
Folic Acid
935E97BOY8
Thiamine
X66NSO3N35
Types de publication
Journal Article
Meta-Analysis
Langues
eng
Sous-ensembles de citation
IM
Pagination
105209Subventions
Organisme : NIAID NIH HHS
ID : R01 AI095066
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Références
J Nutr. 1977 Sep;107(9):1707-14
pubmed: 894368
Metab Brain Dis. 1991 Dec;6(4):207-12
pubmed: 1812394
EcoSal Plus. 2007 Apr;2(2):
pubmed: 26443589
Clin Nutr. 1999 Dec;18(6):375-8
pubmed: 10634924
Trop Doct. 2009 Apr;39(2):83-5
pubmed: 19299288
Amino Acids. 2013 Sep;45(3):463-77
pubmed: 23615880
Am J Gastroenterol. 1998 Jun;93(6):972-5
pubmed: 9647031
AIDS. 2017 Mar 27;31(6):857-862
pubmed: 28118207
Biochem Biophys Res Commun. 1968 Jan 25;30(2):111-7
pubmed: 4384443
Nutrition. 1999 Nov-Dec;15(11-12):860-4
pubmed: 10575661
Vitam Horm. 2007;75:355-83
pubmed: 17368322
Front Genet. 2015 Apr 20;6:148
pubmed: 25941533
Curr Atheroscler Rep. 2014 Sep;16(9):435
pubmed: 25037581
Ann Vasc Surg. 2006 Sep;20(5):653-8
pubmed: 16741654
Nat Med. 2018 Jul;24(7):1070-1080
pubmed: 29942096
J Magn Reson Imaging. 2010 Nov;32(5):1045-53
pubmed: 21031507
AIDS. 1996 Jul;10(8):931-2
pubmed: 8828758
AIDS Res Hum Retroviruses. 2017 Jul;33(7):681-689
pubmed: 28117597
J Nutr. 1998 Aug;128(8):1342-8
pubmed: 9687554
Sci Rep. 2016 May 18;6:26192
pubmed: 27189771
J Appl Physiol (1985). 1995 Jul;79(1):146-50
pubmed: 7559212
Nutr Neurosci. 2015;18(8):355-64
pubmed: 26263423
Am J Physiol. 1999 Oct;277(4):E597-607
pubmed: 10516118
Appl Environ Microbiol. 2009 Dec;75(23):7537-41
pubmed: 19801464
BMC Bioinformatics. 2016 Oct 10;17(1):420
pubmed: 27724866
JAMA. 1995 Oct 4;274(13):1049-57
pubmed: 7563456
Clin Res Cardiol. 2012 Mar;101(3):159-64
pubmed: 22057652
Diabetes Metab Syndr. 2015 Oct-Dec;9(4):213-7
pubmed: 25982678
J Exp Biol. 2014 Jun 1;217(Pt 11):1894-901
pubmed: 24577449
Sci Rep. 2018 Jun 27;8(1):9749
pubmed: 29950689
EBioMedicine. 2016 Jan 28;5:135-46
pubmed: 27077120
Front Nutr. 2019 Apr 17;6:48
pubmed: 31058161
ISME J. 2018 Aug;12(8):1964-1976
pubmed: 29789624
Xenobiotica. 2014 May;44(5):480-8
pubmed: 24494987
Trends Cardiovasc Med. 2017 Nov;27(8):558-563
pubmed: 28779949
Br J Nutr. 1999 Mar;81(3):181-9
pubmed: 10434844
Am J Med. 1995 May;98(5):485-90
pubmed: 7733128
Clin Chem Lab Med. 1998 Jun;36(7):419-29
pubmed: 9746265
Am J Med Sci. 2017 Oct;354(4):379-387
pubmed: 29078842
J Am Coll Cardiol. 2017 Jun 27;69(25):3084-3098
pubmed: 28641798
Cell Host Microbe. 2016 Mar 9;19(3):311-22
pubmed: 26962942
Nature. 1974 Feb 1;247(5439):290-2
pubmed: 4206476
J Int AIDS Soc. 2017 Mar 8;20(1):21526
pubmed: 28362071
J Clin Gastroenterol. 2008 Sep;42 Suppl 3 Pt 2:S179-84
pubmed: 18685499
Nature. 2019 May;569(7758):655-662
pubmed: 31142855
Cell Host Microbe. 2013 Sep 11;14(3):329-39
pubmed: 24034618
J Biol Regul Homeost Agents. 2015 Apr-Jun;29(2):283-8
pubmed: 26122215
J Nutr Sci Vitaminol (Tokyo). 1979;25(3):131-9
pubmed: 501446
Trends Genet. 2013 Jan;29(1):51-8
pubmed: 23140990
N Engl J Med. 2004 Jul 1;351(1):23-32
pubmed: 15229304
Metabolites. 2019 Sep 30;9(10):
pubmed: 31574898
Nat Rev Neurol. 2016 May;12(5):309
pubmed: 27080521
J Nutr. 2008 Oct;138(10):1996S-2002S
pubmed: 18806114
Curr Opin Gastroenterol. 2006 Mar;22(2):140-6
pubmed: 16462170
Clin Infect Dis. 2007 Jun 15;44(12):1625-31
pubmed: 17516408
Evol Bioinform Online. 2016 May 12;12(Suppl 1):5-16
pubmed: 27199545
Am J Epidemiol. 1996 Jun 15;143(12):1244-56
pubmed: 8651223
Clin Chem. 1988 Sep;34(9):1787-9
pubmed: 2901300
J Am Diet Assoc. 1996 Jun;96(6):565-9
pubmed: 8655902
J Biomed Inform X. 2019 Jun;2:
pubmed: 31482150
J Nutr. 2000 Jul;130(7):1857S-64S
pubmed: 10867063
Circ J. 2018 May 25;82(6):1640-1650
pubmed: 29607983
Sci Rep. 2017 Jul 24;7(1):6269
pubmed: 28740260
Mucosal Immunol. 2017 Sep;10(5):1279-1293
pubmed: 28000678
Am J Clin Nutr. 1999 Dec;70(6):1046-58
pubmed: 10584050
Ochsner J. 2013 Winter;13(4):495-9
pubmed: 24357996
J Nutr. 2007 Dec;137(12):2742-6
pubmed: 18029493
J Mol Med (Berl). 2000;78(1):55-62
pubmed: 10759030
Clin Infect Dis. 2020 Feb 3;70(4):615-627
pubmed: 30921452
Exp Mol Pathol. 2019 Jun;108:64-72
pubmed: 30922769
Clin Chem. 1994 May;40(5):785-9
pubmed: 7909726
Curr Opin Biotechnol. 2013 Apr;24(2):160-8
pubmed: 22940212
Metabolites. 2019 Jun 11;9(6):
pubmed: 31212603
Mucosal Immunol. 2014 Jul;7(4):983-94
pubmed: 24399150
Nat Methods. 2010 May;7(5):335-6
pubmed: 20383131
Alcohol Alcohol. 2009 Mar-Apr;44(2):141-7
pubmed: 19151161
J Clin Endocrinol Metab. 2007 Jul;92(7):2506-12
pubmed: 17456578
Curr Genet. 2005 Mar;47(3):156-62
pubmed: 15614489
Mol Immunol. 2013 Jun;54(2):164-72
pubmed: 23280395
Inflamm Bowel Dis. 2014 Apr;20(4):723-31
pubmed: 24583479
Microbiome. 2018 Nov 5;6(1):198
pubmed: 30396369
Lancet. 1990 Jun 9;335(8702):1401-2
pubmed: 1971680
Mucosal Immunol. 2017 Jul;10(4):996-1007
pubmed: 27848950
Nutr Metab Cardiovasc Dis. 2018 Oct;28(10):965-972
pubmed: 30143411
J Neurosci Rural Pract. 2016 Jul-Sep;7(3):362-7
pubmed: 27365952
Rambam Maimonides Med J. 2018 Jul 30;9(3):
pubmed: 29944113