The Role of Chitosan Oligosaccharide in Metabolic Syndrome: A Review of Possible Mechanisms.


Journal

Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729

Informations de publication

Date de publication:
01 Sep 2021
Historique:
received: 17 08 2021
revised: 30 08 2021
accepted: 31 08 2021
entrez: 26 9 2021
pubmed: 27 9 2021
medline: 18 1 2022
Statut: epublish

Résumé

Metabolic syndrome, a cluster of metabolic disorders including central obesity, insulin resistance, hyperglycemia, dyslipidemia, and hypertension, has become a major public health problem worldwide. It is of great significance to develop natural products to prevent and treat metabolic syndrome. Chitosan oligosaccharide (COS) is an oligomer of chitosan prepared by the deacetylation of chitin, which is the second most abundant polymer in nature. In recent years, COS has received widespread attention due to its various biological activities. The present review will summarize the evidence from both in vitro and in vivo studies of the beneficial effects of COS on obesity, dyslipidemia, diabetes mellitus, hyperglycemia, and hypertension, and focus attention on possible mechanisms of the prevention and treatment of metabolic syndrome by COS.

Identifiants

pubmed: 34564163
pii: md19090501
doi: 10.3390/md19090501
pmc: PMC8465579
pii:
doi:

Substances chimiques

Anticholesteremic Agents 0
Oligosaccharides 0
Chitosan 9012-76-4

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Hubei Technological Innovation Special Fund (CN)
ID : 2019ABA081
Organisme : Open Project of Key Laboratory of Molecular Animal Nutrition of Ministry of Education, Zhejiang University
ID : KLMAN202001

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Auteurs

Wenjing Tao (W)

Hubei Key Laboratory of Animal Embryo and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan 430064, China.

Geng Wang (G)

Key Laboratory of Molecular Animal Nutrition, Ministry of Education, College of Animal Science, Zhejiang University, Hangzhou 310058, China.

Jintao Wei (J)

Hubei Key Laboratory of Animal Embryo and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan 430064, China.

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Classifications MeSH