Reduced L-Arginine and L-Arginine-ADMA-Ratio, and Increased SDMA after Norseman Xtreme Triathlon.
ADMA
L-arginine
NO
SDMA
ironman
triathlon
Journal
Sports (Basel, Switzerland)
ISSN: 2075-4663
Titre abrégé: Sports (Basel)
Pays: Switzerland
ID NLM: 101722684
Informations de publication
Date de publication:
31 Aug 2021
31 Aug 2021
Historique:
received:
28
06
2021
revised:
28
07
2021
accepted:
26
08
2021
entrez:
26
9
2021
pubmed:
27
9
2021
medline:
27
9
2021
Statut:
epublish
Résumé
Endothelial vasodilatory function is dependent on the NO synthesis from L-arginine by endothelial NO-synthetase (eNOS). eNOS can be inhibited by asymmetric dimethylarginine (ADMA) by competitive inhibition on the binding site, and symmetric dimethylarginine (SDMA) can reduce the L-arginine availability intracellularly through competing for transport over the cellular membrane. To study the NO synthesis after prolonged exercise, we assessed circulatory L-arginine, the L-arginine/ADMA ratio, and SDMA before, after, and on the day after the Norseman Xtreme triathlon, an Ironman distance triathlon. We found significantly reduced levels of L-arginine and the L-arginine/ADMA ratio and increased levels of SDMA after the race (all
Identifiants
pubmed: 34564325
pii: sports9090120
doi: 10.3390/sports9090120
pmc: PMC8472968
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Aker BioMarine Antarctic AS
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