Increased Fibroblast Growth Factor 21 (FGF21) Concentration in Early Second Trimester Amniotic Fluid and Its Association with Fetal Growth.
amniotic fluid
fetal growth
fetal growth restriction
fibroblast growth factor 21 (FGF21)
insulin
small for gestational age (SGA)
Journal
Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790
Informations de publication
Date de publication:
28 Aug 2021
28 Aug 2021
Historique:
received:
18
07
2021
revised:
20
08
2021
accepted:
25
08
2021
entrez:
26
9
2021
pubmed:
27
9
2021
medline:
27
9
2021
Statut:
epublish
Résumé
Altered fetal growth, either reduced or exacerbated, is associated with adverse perinatal outcomes. The underlying pathogenetic mechanisms of altered growth remain unclear. Fibroblast growth factor 21 (FGF21) and insulin are both considered to be major regulators of tissue growth and metabolism. The aim of our study was to investigate the association of second trimester amniotic fluid FGF21 and insulin concentrations with fetal growth. The amniotic fluid concentrations of FGF21 and insulin were determined in 80 cases of different fetal growth patterns (SGA-small for gestational age, LGA-large for gestational age, and AGA-appropriate for gestational age fetuses). Both peptides were found to be increased in cases of abnormal fetal growth, reduced growth velocity (SGA), or macrosomia (LGA). Specifically, FGF21 was significantly increased, as higher FGF21 levels were observed in the amniotic fluid of SGA and LGA fetuses compared with AGA fetuses (
Identifiants
pubmed: 34564397
pii: metabo11090581
doi: 10.3390/metabo11090581
pmc: PMC8470231
pii:
doi:
Types de publication
Journal Article
Langues
eng
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