Lipidomic Signatures of Changes in Adiposity: A Large Prospective Study of 5849 Adults from the Australian Diabetes, Obesity and Lifestyle Study.
change in BMI
change in WC
metabolic scores
plasma lipidomics
Journal
Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790
Informations de publication
Date de publication:
21 Sep 2021
21 Sep 2021
Historique:
received:
25
08
2021
revised:
19
09
2021
accepted:
19
09
2021
entrez:
26
9
2021
pubmed:
27
9
2021
medline:
27
9
2021
Statut:
epublish
Résumé
Lipid metabolism is tightly linked to adiposity. Comprehensive lipidomic profiling offers new insights into the dysregulation of lipid metabolism in relation to weight gain. Here, we investigated the relationship of the human plasma lipidome and changes in waist circumference (WC) and body mass index (BMI). Adults (2653 men and 3196 women), 25-95 years old who attended the baseline survey of the Australian Diabetes, Obesity and Lifestyle Study (AusDiab) and the 5-year follow-up were enrolled. A targeted lipidomic approach was used to quantify 706 distinct molecular lipid species in the plasma samples. Multiple linear regression models were used to examine the relationship between the baseline lipidomic profile and changes in WC and BMI. Metabolic scores for change in WC were generated using a ridge regression model. Alkyl-diacylglycerol such as TG(O-50:2) [NL-18:1] displayed the strongest association with change in WC (β-coefficient = 0.125 cm increment per SD increment in baseline lipid level,
Identifiants
pubmed: 34564462
pii: metabo11090646
doi: 10.3390/metabo11090646
pmc: PMC8471381
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Health and Medical Research Council
ID : APP1101320
Références
Nature. 2006 Dec 21;444(7122):1009-10
pubmed: 17183300
Biol Sex Differ. 2012 May 31;3(1):13
pubmed: 22651247
Lipids Health Dis. 2018 Oct 15;17(1):237
pubmed: 30322392
Biochim Biophys Acta. 2014 Oct;1842(10):1563-70
pubmed: 25128765
Diabetes Care. 2006 Feb;29(2):404-9
pubmed: 16443895
Diabetologia. 2010 Dec;53(12):2538-45
pubmed: 20740271
Obesity (Silver Spring). 2014 Jun;22(6):1538-45
pubmed: 24436317
Arterioscler Thromb Vasc Biol. 2020 Jul;40(7):1787-1800
pubmed: 32460579
Mar Drugs. 2010 Jul 19;8(7):2175-84
pubmed: 20714431
Diabetes Care. 2019 Aug;42(8):1406-1413
pubmed: 31182488
Obesity (Silver Spring). 2010 Sep;18(9):1695-700
pubmed: 20111019
Nutr Metab (Lond). 2013 Jun 17;10(1):42
pubmed: 23773230
BMJ Open Diabetes Res Care. 2020 Oct;8(1):
pubmed: 33004401
Nature. 2006 Dec 21;444(7122):1027-31
pubmed: 17183312
Diabetes. 2002 Oct;51(10):2944-50
pubmed: 12351431
J Clin Invest. 2019 Feb 1;129(2):694-711
pubmed: 30511960
Front Bioeng Biotechnol. 2020 Jan 24;8:6
pubmed: 32039191
Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15718-23
pubmed: 15505215
PLoS Biol. 2020 Sep 28;18(9):e3000870
pubmed: 32986697
Nat Rev Endocrinol. 2020 Mar;16(3):177-189
pubmed: 32020062
Am J Clin Nutr. 2002 Jul;76(1):107-12
pubmed: 12081823
Med J Aust. 2003 Aug 4;179(3):135-9
pubmed: 12885281
Diabetes Care. 2007 Dec;30(12):3105-9
pubmed: 17712026
J Clin Endocrinol Metab. 2020 Mar 1;105(3):
pubmed: 32016362
Curr Opin Cardiol. 2018 Sep;33(5):500-505
pubmed: 29965801
Int J Prev Med. 2015 Jan 15;6:5
pubmed: 25789140
J Lipid Res. 2013 Oct;54(10):2898-908
pubmed: 23868910
Int J Mol Sci. 2020 Feb 21;21(4):
pubmed: 32098263
J Clin Invest. 2019 May 13;129(6):2485-2499
pubmed: 31081799
PLoS Med. 2014 Dec 09;11(12):e1001765
pubmed: 25490400
Diabetologia. 2019 Dec;62(12):2298-2309
pubmed: 31584131
PLoS One. 2013 Jul 16;8(7):e67429
pubmed: 23874419
Cell Metab. 2018 Jul 03;28(1):45-54.e3
pubmed: 29861390
Atherosclerosis. 2012 Jul;223(1):239-43
pubmed: 22658258
Am J Clin Nutr. 2020 Feb 1;111(2):420-428
pubmed: 31826243
Metabolites. 2014 Sep 25;4(3):831-78
pubmed: 25257998
Lancet. 2018 May 5;391(10132):1773-1774
pubmed: 29739565
FASEB J. 2015 Jan;29(1):336-45
pubmed: 25342132
Biochimie. 2011 Jan;93(1):1-3
pubmed: 20036307
J Clin Endocrinol Metab. 2019 May 1;104(5):1508-1519
pubmed: 30423132
Asia Pac J Clin Nutr. 1994 Mar;3(1):19-31
pubmed: 24351203
Cell Metab. 2019 Feb 5;29(2):488-500.e2
pubmed: 30318341
EBioMedicine. 2020 Jan;51:102520
pubmed: 31877415
Biol Sex Differ. 2019 Feb 26;10(1):11
pubmed: 30808418
BMJ. 2018 Mar 29;360:k1274
pubmed: 29599212
Am J Clin Nutr. 2006 Mar;83(3):575-81
pubmed: 16522903
Diabetes Metab Res Rev. 2018 Jan;34(1):
pubmed: 28886616
Metabolites. 2015 Jun 17;5(2):389-403
pubmed: 26090945
Am J Clin Nutr. 2019 Feb 1;109(2):433-441
pubmed: 30649213
Med Sci Sports Exerc. 2011 Feb;43(2):280-6
pubmed: 20543753
PLoS Med. 2016 Jul 19;13(7):e1002094
pubmed: 27434045
PLoS One. 2013 Sep 27;8(9):e74341
pubmed: 24086336
Arterioscler Thromb Vasc Biol. 2018 Feb;38(2):438-447
pubmed: 29284607
Diabetes Res Clin Pract. 2002 Aug;57(2):119-29
pubmed: 12062857
Schizophr Bull. 2021 Jan 23;47(1):160-169
pubmed: 32609372
Biol Sex Differ. 2017 Mar 28;8:10
pubmed: 28360990