The utility of basic blood counts, WBC histogram and C-reactive protein in detecting malaria.
CRP
Hematology analyzer
Malaria infection
WBC histogram
Journal
BMC infectious diseases
ISSN: 1471-2334
Titre abrégé: BMC Infect Dis
Pays: England
ID NLM: 100968551
Informations de publication
Date de publication:
26 Sep 2021
26 Sep 2021
Historique:
received:
06
09
2020
accepted:
16
09
2021
entrez:
27
9
2021
pubmed:
28
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Hematology analyzers display abnormal parameters during malaria infection providing insightful information for suspecting and assessing malaria infection. The goal of this study is to demonstrate the potential of a three-part differential hematology analyzer to assess malaria, provide information about the parasitemia, and discuss the importance of combining C-reactive protein (CRP) with hematology parameters to obtain further information about the malaria infection. The present study shows the results of a case-control study during the monsoon season of years 2018 and 2019 in Mumbai, India. The study considers 1008 non-malaria febrile cases, 209 P. vivax and 31 P. falciparum positive malaria samples, five cases of mixed P. vivax and P. falciparum infection, and three co-infection cases of P. vivax and dengue. Raw data from the three-part analyzer LC-667G CRP (HORIBA) and the corresponding microscopic findings (golden standard for diagnosis of malaria) were obtained for each sample. The medians of platelet counts (PLT) were 102.5, 109.0, and 223.0 × 10 A three-part differential hematology analyzer has the potential to not only trigger malaria diagnosis confirmation but also assess the severity of the infection when CRP is considered.
Sections du résumé
BACKGROUND
BACKGROUND
Hematology analyzers display abnormal parameters during malaria infection providing insightful information for suspecting and assessing malaria infection. The goal of this study is to demonstrate the potential of a three-part differential hematology analyzer to assess malaria, provide information about the parasitemia, and discuss the importance of combining C-reactive protein (CRP) with hematology parameters to obtain further information about the malaria infection.
METHODS
METHODS
The present study shows the results of a case-control study during the monsoon season of years 2018 and 2019 in Mumbai, India. The study considers 1008 non-malaria febrile cases, 209 P. vivax and 31 P. falciparum positive malaria samples, five cases of mixed P. vivax and P. falciparum infection, and three co-infection cases of P. vivax and dengue. Raw data from the three-part analyzer LC-667G CRP (HORIBA) and the corresponding microscopic findings (golden standard for diagnosis of malaria) were obtained for each sample.
RESULTS
RESULTS
The medians of platelet counts (PLT) were 102.5, 109.0, and 223.0 × 10
CONCLUSIONS
CONCLUSIONS
A three-part differential hematology analyzer has the potential to not only trigger malaria diagnosis confirmation but also assess the severity of the infection when CRP is considered.
Identifiants
pubmed: 34565334
doi: 10.1186/s12879-021-06704-5
pii: 10.1186/s12879-021-06704-5
pmc: PMC8474782
doi:
Substances chimiques
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1006Informations de copyright
© 2021. The Author(s).
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