Assessing the anti-resistance potential of public health vaporizer formulations and insecticide mixtures with pyrethroids using transgenic Drosophila lines.
Animals
Animals, Genetically Modified
/ genetics
Drosophila melanogaster
/ drug effects
Drug Compounding
Drug Evaluation
Guanidines
/ chemistry
Insecticide Resistance
Insecticides
/ chemistry
Mosquito Control
/ instrumentation
Mosquito Vectors
/ drug effects
Nebulizers and Vaporizers
Neonicotinoids
/ chemistry
Nitriles
/ chemistry
Public Health
Pyrethrins
/ chemistry
Thiazoles
/ chemistry
Clothianidin
Deltamethrin
Drosophila melanogaster
Fludora fusion
Insecticide mixtures
Resistance
Transfluthrin
Journal
Parasites & vectors
ISSN: 1756-3305
Titre abrégé: Parasit Vectors
Pays: England
ID NLM: 101462774
Informations de publication
Date de publication:
26 Sep 2021
26 Sep 2021
Historique:
received:
16
04
2021
accepted:
08
09
2021
entrez:
27
9
2021
pubmed:
28
9
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Insecticide resistance-and especially pyrethroid resistance-is a major challenge for vector control in public health. The use of insecticide mixtures utilizing alternative modes of action, as well as new formulations facilitating their uptake, is likely to break resistance and slow the development of resistance. We used genetically defined highly resistant lines of Drosophila melanogaster with distinct target-site mutations and detoxification enzymes to test the efficacy and anti-resistance potential of novel mixture formulations (i.e. Fludora The commercial mixture Fludora The use of mixtures containing two unrelated modes of action as well as a formulation based on transfluthrin showed increased efficacy and resistance-breaking potential against genetically defined highly resistant Drosophila flies. The experimental model remains to be validated with mosquito populations in the field. The possible introduction of new transfluthrin-based products and mixtures for indoor residual spraying, in line with other combination and mixture vector control products recently evaluated for use in public health, will provide solutions for better insecticide resistance management.
Sections du résumé
BACKGROUND
BACKGROUND
Insecticide resistance-and especially pyrethroid resistance-is a major challenge for vector control in public health. The use of insecticide mixtures utilizing alternative modes of action, as well as new formulations facilitating their uptake, is likely to break resistance and slow the development of resistance.
METHODS
METHODS
We used genetically defined highly resistant lines of Drosophila melanogaster with distinct target-site mutations and detoxification enzymes to test the efficacy and anti-resistance potential of novel mixture formulations (i.e. Fludora
RESULTS
RESULTS
The commercial mixture Fludora
CONCLUSIONS
CONCLUSIONS
The use of mixtures containing two unrelated modes of action as well as a formulation based on transfluthrin showed increased efficacy and resistance-breaking potential against genetically defined highly resistant Drosophila flies. The experimental model remains to be validated with mosquito populations in the field. The possible introduction of new transfluthrin-based products and mixtures for indoor residual spraying, in line with other combination and mixture vector control products recently evaluated for use in public health, will provide solutions for better insecticide resistance management.
Identifiants
pubmed: 34565459
doi: 10.1186/s13071-021-04997-8
pii: 10.1186/s13071-021-04997-8
pmc: PMC8474913
doi:
Substances chimiques
Guanidines
0
Insecticides
0
Neonicotinoids
0
Nitriles
0
Pyrethrins
0
Thiazoles
0
decamethrin
2JTS8R821G
clothianidin
2V9906ABKQ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
495Informations de copyright
© 2021. The Author(s).
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