Impaired Autophagy in Psoriasis and Atopic Dermatitis: A New Therapeutic Target?

Autophagy Dermatitis, Atopic / drug therapy Humans Keratinocytes Psoriasis / drug therapy Skin

Journal

The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720

Informations de publication

Date de publication:
12 2021
Historique:
received: 20 06 2021
revised: 22 06 2021
accepted: 22 06 2021
pubmed: 28 9 2021
medline: 15 12 2021
entrez: 27 9 2021
Statut: ppublish

Résumé

Dysfunctional autophagy is linked to various diseases, including psoriasis and atopic dermatitis. Recent evidence suggests that exposure of keratinocytes to TNF-α results in impaired autophagy and lysosomal function. The skin of patients with psoriasis and atopic dermatitis reveals a decreased expression of lysosomal cathepsins. Impaired autophagy is presumably involved in inflammation and disturbed keratinocyte differentiation, whereas stimulating autophagy might be a treatment option in inflammatory skin disease.

Identifiants

DOI: 10.1016/j.jid.2021.06.006 PMID: 34565564
pubmed: 34565564
pii: S0022-202X(21)01409-3
doi: 10.1016/j.jid.2021.06.006
pii:
doi:

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

2775-2777

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Stephan Hailfinger (S)

Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Münster, Münster, Germany.

Klaus Schulze-Osthoff (K)

Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tübingen, Tübingen, Germany. Electronic address: kso@uni-tuebingen.de.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Autophagie › Impaired Autophagy in Psoriasis and Atopic...
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Eczéma atopique › Impaired Autophagy in Psoriasis and Atopic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Impaired Autophagy in Psoriasis and Atopic...
questionsmedicales.fr › Cellules › Cellules épithéliales › Kératinocytes › Impaired Autophagy in Psoriasis and Atopic...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Dermatoses papulosquameuses › Psoriasis › Impaired Autophagy in Psoriasis and Atopic...
questionsmedicales.fr › Système tégumentaire › Peau › Impaired Autophagy in Psoriasis and Atopic...