Exploring six-coordinate germanium(IV)-diketonate complexes as anticancer agents.
Anticancer
Cytotoxicity
Drug discovery
Germanium
Metalloid
Resistance
Journal
Inorganica chimica acta
ISSN: 0020-1693
Titre abrégé: Inorganica Chim Acta
Pays: Switzerland
ID NLM: 9875013
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
entrez:
27
9
2021
pubmed:
1
4
2020
medline:
1
4
2020
Statut:
ppublish
Résumé
Cancer remains one of the leading causes of death worldwide and despite several attempts using chemotherapy to combat the deadly disease, toxic side effects and drug resistance temper efficacy [1]. Thus, drugs with potentially new mechanisms and lower toxicity to normal cells are needed. Metalloids such as arsenic compounds have been clinically beneficial in fighting cancer, but germanium is yet to gain such prominence [2,3]. We report the synthesis of four octahedral germanium(IV) complexes bearing acetylacetonato ligand, [Ge
Identifiants
pubmed: 34565828
doi: 10.1016/j.ica.2019.119375
pmc: PMC8460083
mid: NIHMS1649850
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM130456
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA177558
Pays : United States
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