Dynamic Patterns of Global Brain Communication Differentiate Conscious From Unconscious Patients After Severe Brain Injury.
anesthesia
brain injury
coma
consciousness
fMRI
propofol
sevoflurane
unresponsive wakefulness syndrome
Journal
Frontiers in systems neuroscience
ISSN: 1662-5137
Titre abrégé: Front Syst Neurosci
Pays: Switzerland
ID NLM: 101477946
Informations de publication
Date de publication:
2021
2021
Historique:
received:
04
11
2020
accepted:
17
08
2021
entrez:
27
9
2021
pubmed:
28
9
2021
medline:
28
9
2021
Statut:
epublish
Résumé
The neurophysiology of the subjective sensation of being conscious is elusive; therefore, it remains controversial how consciousness can be recognized in patients who are not responsive but seemingly awake. During general anesthesia, a model for the transition between consciousness and unconsciousness, specific covariance matrices between the activity of brain regions that we call patterns of global brain communication reliably disappear when people lose consciousness. This functional magnetic imaging study investigates how patterns of global brain communication relate to consciousness and unconsciousness in a heterogeneous sample during general anesthesia and after brain injury. First, we describe specific patterns of global brain communication during wakefulness that disappear during propofol (
Identifiants
pubmed: 34566586
doi: 10.3389/fnsys.2021.625919
pmc: PMC8458756
doi:
Types de publication
Journal Article
Langues
eng
Pagination
625919Informations de copyright
Copyright © 2021 Golkowski, Willnecker, Rösler, Ranft, Schneider, Jordan and Ilg.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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