Near-Infrared Spectroscopy-Derived Dynamic Cerebral Autoregulation in Experimental Human Endotoxemia-An Exploratory Study.
cerebral perfusion
dynamic cerebral autoregulation
human endotoxemia model
near-infrared spectroscopy
sepsis
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2021
2021
Historique:
received:
15
04
2021
accepted:
11
08
2021
entrez:
27
9
2021
pubmed:
28
9
2021
medline:
28
9
2021
Statut:
epublish
Résumé
Cerebral perfusion may be altered in sepsis patients. However, there are conflicting findings on cerebral autoregulation (CA) in healthy participants undergoing the experimental endotoxemia protocol, a proxy for systemic inflammation in sepsis. In the current study, a newly developed near-infrared spectroscopy (NIRS)-based CA index is investigated in an endotoxemia study population, together with an index of focal cerebral oxygenation.
Identifiants
pubmed: 34566840
doi: 10.3389/fneur.2021.695705
pmc: PMC8461327
doi:
Banques de données
ClinicalTrials.gov
['NCT02922673']
Types de publication
Journal Article
Langues
eng
Pagination
695705Informations de copyright
Copyright © 2021 Eleveld, Hoedemaekers, van Kaam, Leijte, van den Brule, Pickkers, Aries, Maurits and Elting.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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