From Merkel Cell Polyomavirus Infection to Merkel Cell Carcinoma Oncogenesis.
Merkel cell carcinoma
Merkel cell polyomavirus
dysbiosis
innate immune response
integration
oncogenesis
persistence
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2021
2021
Historique:
received:
11
07
2021
accepted:
09
08
2021
entrez:
27
9
2021
pubmed:
28
9
2021
medline:
28
9
2021
Statut:
epublish
Résumé
Merkel cell polyomavirus (MCPyV) infection causes near-ubiquitous, asymptomatic infection in the skin, but occasionally leads to an aggressive skin cancer called Merkel cell carcinoma (MCC). Epidemiological evidence suggests that poorly controlled MCPyV infection may be a precursor to MCPyV-associated MCC. Clearer understanding of host responses that normally control MCPyV infection could inform prophylactic measures in at-risk groups. Similarly, the presence of MCPyV in most MCCs could imbue them with vulnerabilities that-if better characterized-could yield targeted intervention solutions for metastatic MCC cases. In this review, we discuss recent developments in elucidating the interplay between host cells and MCPyV within the context of viral infection and MCC oncogenesis. We also propose a model in which insufficient restriction of MCPyV infection in aging and chronically UV-damaged skin causes unbridled viral replication that licenses MCC tumorigenesis.
Identifiants
pubmed: 34566942
doi: 10.3389/fmicb.2021.739695
pmc: PMC8457551
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
739695Subventions
Organisme : NCI NIH HHS
ID : R01 CA187718
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI149761
Pays : United States
Organisme : NIAMS NIH HHS
ID : R21 AR074073
Pays : United States
Informations de copyright
Copyright © 2021 Krump and You.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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