Identification of New Genes and Loci Associated With Bone Mineral Density Based on Mendelian Randomization.
BMD
GWAS
SMR
causative gene
disease susceptibility
eQTL
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2021
2021
Historique:
received:
21
06
2021
accepted:
02
08
2021
entrez:
27
9
2021
pubmed:
28
9
2021
medline:
28
9
2021
Statut:
epublish
Résumé
Bone mineral density (BMD) is a complex and highly hereditary trait that can lead to osteoporotic fractures. It is estimated that BMD is mainly affected by genetic factors (about 85%). BMD has been reported to be associated with both common and rare variants, and numerous loci related to BMD have been identified by genome-wide association studies (GWAS). We systematically integrated expression quantitative trait loci (eQTL) data with GWAS summary statistical data. We mainly focused on the loci, which can affect gene expression, so Summary data-based Mendelian randomization (SMR) analysis was implemented to investigate new genes and loci associated with BMD. We identified 12,477 single-nucleotide polymorphisms (SNPs) regulating 564 genes, which are associated with BMD. The genetic mechanism we detected could make a contribution in the density of BMD in individuals and play an important role in understanding the pathophysiology of cataclasis.
Identifiants
pubmed: 34567079
doi: 10.3389/fgene.2021.728563
pmc: PMC8456003
doi:
Types de publication
Journal Article
Langues
eng
Pagination
728563Informations de copyright
Copyright © 2021 Liu, Jin, Wang, Dong and Ding.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Nat Genet. 2012 Oct;44(10):1084-9
pubmed: 22941192
J Clin Invest. 2010 Jun;120(6):1981-93
pubmed: 20501942
Nat Genet. 2013 Oct;45(10):1238-1243
pubmed: 24013639
PLoS Genet. 2009 Aug;5(8):e1000608
pubmed: 19680542
Curr Osteoporos Rep. 2012 Sep;10(3):228-35
pubmed: 22802146
Osteoporos Int. 2006;17(6):865-71
pubmed: 16541205
Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):7568-7569
pubmed: 32184333
Curr Gene Ther. 2019;19(4):224-231
pubmed: 31553296
Hum Mol Genet. 2014 Jun 1;23(11):3054-68
pubmed: 24430505
J Bone Miner Res. 1996 Apr;11(4):530-4
pubmed: 8992884
Sci Rep. 2021 Feb 24;11(1):4482
pubmed: 33627720
Bioinformatics. 2020 Aug 15;36(16):4466-4472
pubmed: 32467970
PLoS One. 2019 Mar 13;14(3):e0213962
pubmed: 30865700
Mol Cell Proteomics. 2011 Nov;10(11):M111.011700
pubmed: 21817168
Nat Genet. 2016 May;48(5):481-7
pubmed: 27019110
Nature. 2015 Oct 1;526(7571):112-7
pubmed: 26367794
Brief Bioinform. 2021 Mar 22;22(2):2141-2150
pubmed: 32367110
Pharmacogenomics J. 2015 Apr;15(2):158-64
pubmed: 25223561
Nat Genet. 2012 Apr 15;44(5):491-501
pubmed: 22504420
Curr Gene Ther. 2020;20(5):383-394
pubmed: 33019928
Nucleic Acids Res. 2021 Jan 8;49(D1):D1413-D1419
pubmed: 33010177
Brief Bioinform. 2021 Sep 2;22(5):
pubmed: 33554247
J Sci Med Sport. 2000 Sep;3(3):268-79
pubmed: 11101266
Science. 2010 Feb 5;327(5966):656-61
pubmed: 20133564
Nat Genet. 2010 Apr;42(4):295-302
pubmed: 20190752
Front Genet. 2019 Oct 25;10:1021
pubmed: 31708967
Osteoporos Int. 2009 Feb;20(2):341-6
pubmed: 18597038
Osteoporos Int. 2007 Jun;18(6):771-7
pubmed: 17273893
J Immunol. 2001 Sep 1;167(5):2625-31
pubmed: 11509604
J Biol Chem. 2005 Aug 12;280(32):29011-6
pubmed: 15965235
Brief Bioinform. 2021 Jul 20;22(4):
pubmed: 33048110
JAMA. 2007 Dec 19;298(23):2761-7
pubmed: 18165669
J Bone Miner Res. 2018 May;33(5):945-958
pubmed: 29314205
Control Clin Trials. 1981 May;2(1):31-49
pubmed: 7261638
PLoS Genet. 2011 May;7(5):e1002078
pubmed: 21637794
PLoS Genet. 2011 Aug;7(8):e1002197
pubmed: 21829388
Nat Genet. 2017 Oct;49(10):1468-1475
pubmed: 28869591
Osteoporos Int. 2005 Aug;16(8):963-8
pubmed: 15599495
Genome Res. 2009 Nov;19(11):1942-52
pubmed: 19654370
Nature. 2009 Sep 10;461(7261):218-23
pubmed: 19741703
Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):3915-3916
pubmed: 32047041
PLoS Genet. 2010 Apr 01;6(4):e1000888
pubmed: 20369019
Adv Genet. 2008;60:571-601
pubmed: 18358333
J Bone Miner Res. 2004 May;19(5):782-93
pubmed: 15068502