Evaluating of the Effects of Sub-MIC Concentrations of Gentamicin on Biofilm Formation in Clinical Isolates of
Biofilm
Pseudomonas aeruginosa
pelA
pslA
Journal
Iranian journal of pathology
ISSN: 1735-5303
Titre abrégé: Iran J Pathol
Pays: Iran
ID NLM: 101515128
Informations de publication
Date de publication:
2021
2021
Historique:
received:
01
02
2021
accepted:
21
06
2021
entrez:
27
9
2021
pubmed:
28
9
2021
medline:
28
9
2021
Statut:
ppublish
Résumé
The ability of Determination of minimal inhibitory concentration of gentamicin for clinical isolates was done using micro broth dilution method. The amount of biofilm formation in the treated and untreated isolates with gentamicin sub-MIC (1/2&1/4MIC) concentrations was evaluated using microtitre plate assay. 99% of clinical isolates were biofilm producer. Different changes in amount of biofilm formation were observed in the treated clinical isolates with sub-MIC concentrations of gentamicin. Two dominant changes were observed in 80% of clinical isolates. These concentrations had inhibitory effect on biofilm formation in 46.4% of isolates and caused a significant decrease in its amount. While in 31.3% of the isolates, the biofilm formation was significantly increased. The frequency of gentamicin sub-MIC concentrations cause different changes on biofilm formation of
Sections du résumé
BACKGROUND & OBJECTIVE
OBJECTIVE
The ability of
METHODS
METHODS
Determination of minimal inhibitory concentration of gentamicin for clinical isolates was done using micro broth dilution method. The amount of biofilm formation in the treated and untreated isolates with gentamicin sub-MIC (1/2&1/4MIC) concentrations was evaluated using microtitre plate assay.
RESULTS
RESULTS
99% of clinical isolates were biofilm producer. Different changes in amount of biofilm formation were observed in the treated clinical isolates with sub-MIC concentrations of gentamicin. Two dominant changes were observed in 80% of clinical isolates. These concentrations had inhibitory effect on biofilm formation in 46.4% of isolates and caused a significant decrease in its amount. While in 31.3% of the isolates, the biofilm formation was significantly increased. The frequency of
CONCLUSION
CONCLUSIONS
gentamicin sub-MIC concentrations cause different changes on biofilm formation of
Identifiants
pubmed: 34567189
doi: 10.30699/IJP.20201.524220.2584
pmc: PMC8463752
doi:
Types de publication
Journal Article
Langues
eng
Pagination
403-410Déclaration de conflit d'intérêts
None.
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